Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 October 2005, Vol. 106, No. 8, pp. 2879-2883.
Prepublished online as a Blood First Edition Paper on June 16, 2005; DOI 10.1182/blood-2005-02-0716.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2005-02-0716v1
106/8/2879    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gunshin, H.
Right arrow Articles by Andrews, N. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gunshin, H.
Right arrow Articles by Andrews, N. C.
Related Collections
Right arrow Red Cells
Right arrowRelated Letter in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

RED CELLS

Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice

Hiromi Gunshin, Carolyn N. Starr, Cristina DiRenzo, Mark D. Fleming, Jie Jin, Eric L. Greer, Vera M. Sellers, Stephanie M. Galica, and Nancy C. Andrews

From the Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; and the Howard Hughes Medical Institute, Boston, MA.

Mammalian nonheme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1-null mice. We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron. (Blood. 2005;106: 2879-2883)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Letter in Blood Online:

The role of duodenal cytochrome b in intestinal iron absorption remains unclear
David M. Frazer, Sarah J. Wilkins, Christopher D. Vulpe, Gregory J. Anderson, Nancy C. Andrews, and Hiromi Gunshin
Blood 2005 106: 4413-4414. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 J. Nutr.Home page
G. O. Latunde-Dada, R. J. Simpson, and A. T. McKie
Duodenal Cytochrome B Expression Stimulates Iron Uptake by Human Intestinal Epithelial Cells
J. Nutr., June 1, 2008; 138(6): 991 - 995.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
A. Mizutani, R. Sanuki, K. Kakimoto, S. Kojo, and S. Taketani
Involvement of 101F6, a Homologue of Cytochrome b561, in the Reduction of Ferric Ions
J. Biochem., December 1, 2007; 142(6): 699 - 705.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. F. Drake, E. H. Morgan, C. E. Herbison, R. Delima, R. M. Graham, A. C. G. Chua, P. J. Leedman, R. E. Fleming, B. R. Bacon, J. K. Olynyk, et al.
Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3
Am J Physiol Gastrointest Liver Physiol, January 1, 2007; 292(1): G323 - G328.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
M J Brookes, S Hughes, F E Turner, G Reynolds, N Sharma, T Ismail, G Berx, A T McKie, N Hotchin, G J Anderson, et al.
Modulation of iron transport proteins in human colorectal carcinogenesis
Gut, October 1, 2006; 55(10): 1449 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
A. Donovan, C. N. Roy, and N. C. Andrews
The Ins and Outs of Iron Homeostasis
Physiology, April 1, 2006; 21(2): 115 - 123.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. M. Frazer, S. J. Wilkins, C. D. Vulpe, G. J. Anderson, N. C. Andrews, and H. Gunshin
The role of duodenal cytochrome b in intestinal iron absorption remains unclear
Blood, December 15, 2005; 106(13): 4413 - 4414.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
B. Mackenzie and M. D. Garrick
Iron Imports. II. Iron uptake at the apical membrane in the intestine
Am J Physiol Gastrointest Liver Physiol, December 1, 2005; 289(6): G981 - G986.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020