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Blood, 15 October 2005, Vol. 106, No. 8, pp. 2890-2895.
Prepublished online as a Blood First Edition Paper on June 23, 2005; DOI 10.1182/blood-2005-03-1053.
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TRANSFUSION MEDICINE
Persistent B19 infection in immunocompetent individuals: implications for transfusion safety
Jean-Jacques Lefrère,
Annabelle Servant-Delmas,
Daniel Candotti,
Martine Mariotti,
Isabelle Thomas,
Yvon Brossard,
François Lefrère,
Robert Girot,
Jean-Pierre Allain, and
Syria Laperche
From the Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, the Centre d'Hémobiologie périnatale, Hôpital Saint-Antoine, the Service d'Hematologie Adultes, Hôpital Necker, and the Laboratoire d'Hematologie, Hôpital Tenon, Paris, France; the Laboratoire d'Hematologie, Centre Hospitalo-Universitaire, Amiens, France; the Department of Haematology, Division of Transfusion Medicine, University of Cambridge, and the National Blood Service, Cambridge, United Kingdom; and the Virology Unit, Scientific Institute of Public Health, Ministry of Public Health, Brussels, Belgium.
Recent reports suggested that parvovirus B19 (B19) might persist in immunocompetent individuals such as blood donors, but only cross-sectional data were available. Serial samples from a cohort of multitransfused patients with hemoglobinopathies and a cross-sectional population of pregnant women were tested for B19 markers. Of 76 red cell recipients, 6 (8%) had persistent viral DNA for 1 to 3 or more years, depending on the sensitivity of the genomic amplification assay. All patients also carried B19-specific immunoglobulin G (IgG). In contrast, 0.8% of 500 pregnant women carried both detectable B19 DNA and specific IgG. These results demonstrate that persistence of low levels of B19 DNA suggested by cross-sectional studies is frequent in multitransfused patients and that the virus may remain detectable several years after infection in nonimmunodeficient individuals. (Blood. 2005;106:2890-2895)
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