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 Blood, 1 January 2006, Vol. 107, No. 1, pp. 184-186.
Prepublished online as a Blood First Edition Paper on September 15, 2005; DOI 10.1182/blood-2005-02-0647.

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IMMUNOBIOLOGY
Brief report

Use of interleukin 7 receptor-{alpha} knockout donor cells demonstrates the lymphoid independence of dendritic cells

Satoshi Takeuchi, and Stephen I. Katz

From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.

The precise lineage of dendritic cells (DCs), including skin Langerhans cells (LCs), is unclear. Interleukin 7 (IL-7) and its receptor (IL-7R{alpha}) are known to mediate lymphopoiesis, and IL-7 is also known to be essential for the generation of DCs from lymphoid-committed precursors in vitro. Thus, to determine the developmental lymphoid (or IL-7R{alpha}) dependency of various DCs and to examine the importance of IL-7/IL-7R{alpha} for DC development in vivo, we used IL-7R{alpha} knockout (KO) donor cells to reconstitute DCs/LCs in sublethally irradiated recipients and compared the results to those obtained using wild-type (WT) donor cells. We found that lymphoid lineage cells (except natural killer [NK] cells), including thymocytes, were less efficiently reconstituted by IL-7R{alpha} KO donor cells, whereas myeloid lineage cells and DCs/LCs were equally well reconstituted by both the IL-7R{alpha} KO and WT donor cells. Overall, we conclude that IL-7R{alpha} is not required for the development of DCs/LC in vivo.


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