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Blood, 1 January 2006, Vol. 107, No. 1, pp. 184-186. Prepublished online as a Blood First Edition Paper on September 15, 2005; DOI 10.1182/blood-2005-02-0647. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: 2005-02-0647v1 107/1/184    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Takeuchi, S. Articles by Katz, S. I. Search for Related Content PubMed PubMed Citation Articles by Takeuchi, S. Articles by Katz, S. I. Related Collections Immunobiology Phagocytes Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief report Use of interleukin 7 receptor- knockout donor cells demonstrates the lymphoid independence of dendritic cells Satoshi Takeuchi, and Stephen I. Katz From the Dermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD. The precise lineage of dendritic cells (DCs), including skin Langerhans cells (LCs), is unclear. Interleukin 7 (IL-7) and its receptor (IL-7R) are known to mediate lymphopoiesis, and IL-7 is also known to be essential for the generation of DCs from lymphoid-committed precursors in vitro. Thus, to determine the developmental lymphoid (or IL-7R) dependency of various DCs and to examine the importance of IL-7/IL-7R for DC development in vivo, we used IL-7R knockout (KO) donor cells to reconstitute DCs/LCs in sublethally irradiated recipients and compared the results to those obtained using wild-type (WT) donor cells. We found that lymphoid lineage cells (except natural killer [NK] cells), including thymocytes, were less efficiently reconstituted by IL-7R KO donor cells, whereas myeloid lineage cells and DCs/LCs were equally well reconstituted by both the IL-7R KO and WT donor cells. Overall, we conclude that IL-7R is not required for the development of DCs/LC in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. K. Vogt, A. Link, J. Perrin, D. Finke, and S. A. Luther Novel function for interleukin-7 in dendritic cell development Blood, April 23, 2009; 113(17): 3961 - 3968. [Abstract] [Full Text] [PDF] J. Li, J. Park, D. Foss, and I. Goldschneider Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus J. Exp. Med., March 16, 2009; 206(3): 607 - 622. [Abstract] [Full Text] [PDF] H. Kohara, Y. Omatsu, T. Sugiyama, M. Noda, N. Fujii, and T. Nagasawa Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling Blood, December 15, 2007; 110(13): 4153 - 4160. [Abstract] [Full Text] [PDF]

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