SEARCH:   Advanced

Blood, 1 January 2006, Vol. 107, No. 1, pp. 190-196. Prepublished online as a Blood First Edition Paper on September 8, 2005; DOI 10.1182/blood-2005-03-1024. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-03-1024v1 107/1/190    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Camilleri-Broët, S. Articles by Martin, A. Search for Related Content PubMed PubMed Citation Articles by Camilleri-Broët, S. Articles by Martin, A. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA A uniform activated B-cell–like immunophenotype might explain the poor prognosis of primary central nervous system lymphomas: analysis of 83 cases Sophie Camilleri-Broët, Emmanuelle Crinière, Philippe Broët, Vincent Delwail, Karima Mokhtari, Anne Moreau, Michèle Kujas, Martine Raphaël, Wafae Iraqi, Catherine Sautès-Fridman, Philippe Colombat, Khê Hoang-Xuan, and Antoine Martin From the Université Paris-Descartes, Faculté de médecine; Hôtel Dieu; Laboratoire de Neuropathologie R. Escourolle; Service de Neurologie Mazarin, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Paris; INSERM U255, Centre de Recherche Biomédical des Cordeliers; INSERM U711, Université P et M Curie Paris VI, Groupe Hospitalier Pitié-Salpêtrière, Paris; Faculté deMédecine Paris-Sud, Service de Santé Publique, AP-HP, Villejuif; Oncologie Hématologique et Thérapie Cellulaire, Hôpital Bernard, Poitiers; Anatomie Pathologique, Hôtel-Dieu, Nantes; Service d'Hématologie et Immunologie Biologiques, Cytogénétique, INSERM E109, CHU Bicêtre, Université Paris-Sud 11, Le Kremlin-Bicêtre; Hématologie, Hôpital Bretonneau, Tours; Faculté de Médecine Paris XIII, Anatomie Pathologique, Hôpital Avicenne, AP-HP, Bobigny; and GOELAMS (Groupe Ouest Est des Leucémies et Autres Maladies du Sang), France. Most primary central nervous system lymphomas (PCNSLs) in immunocompetent patients are diffuse large B-cell lymphomas (DLBCLs), characterized by poor prognosis, compared with systemic forms. A germinal center B-cell–like (GCB) origin of PCNSL was hypothesized on the basis of BCL-6 expression and ongoing mutational activity. Our goal herein was to determine, for 83 PCNSLs, the percentages of GCB and activated B-cell–like (ABC) phenotypes and their prognostic significance. CD10, BCL-6, MUM1, BCL-2, and CD138 antigens were immunohistochemically labeled on paraffin-embedded sections; the first 4 were positive in 2.4%, 55.5%, 92.6%, and 55.5% of the tumors, respectively. None of the 56 tested samples expressed CD138. Among the 82 patients with complete information, 79 (96.3%) were classified as ABC; 42 (51.2%) expressed BCL-6+MUM1+, suggesting an "activated GCB" origin; 33 (40.2%) were exclusively MUM1+, and the remaining 4 (4.9%) were negative for all markers tested. These findings provide new insights into interpreting the poor PCNSL prognostic, which may, in part, be due to biologic aggressiveness associated with its activated B-cell–like pattern. We postulate assigning PCNSL a histogenetic "time-slot," overlapping late GC and early post-GC, that could explain the predominant ABC phenotype observed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Hassan, C. G. Stefanoff, F. Felisbino, M. H. M. Barros, I. R. Zalcberg, C. E. Klumb, R. S. Bigni, and H. N. Seuanez Second Epstein-Barr Virus-Associated Burkitt's Lymphoma of the CNS in a Child With Progressive Renal Failure J. Clin. Oncol., June 20, 2008; 26(18): 3085 - 3087. [Full Text] [PDF] H. W. Tun, D. Personett, K. A. Baskerville, D. M. Menke, K. A. Jaeckle, P. Kreinest, B. Edenfield, A. C. Zubair, B. P. O'Neill, W. R. Lai, et al. Pathway analysis of primary central nervous system lymphoma Blood, March 15, 2008; 111(6): 3200 - 3210. [Abstract] [Full Text] [PDF] J. O. Armitage How I treat patients with diffuse large B-cell lymphoma Blood, July 1, 2007; 110(1): 29 - 36. [Full Text] [PDF] M. Booman, J. Douwes, M.-C. Legdeur, J. van Baarlen, E. Schuuring, and P. Kluin From brain to testis: immune escape and clonal selection in a B cell lymphoma with selective out-growth in two immune sanctuariesy Haematologica, June 1, 2007; 92(6): e69 - e71. [Abstract] [Full Text] [PDF] I. Oschlies, W. Klapper, M. Zimmermann, M. Krams, H.-H. Wacker, B. Burkhardt, L. Harder, R. Siebert, A. Reiter, and R. Parwaresch Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Munster) Multicenter Trial Blood, May 15, 2006; 107(10): 4047 - 4052. [Abstract] [Full Text] [PDF] J. L. Rubenstein, J. Fridlyand, A. Shen, K. Aldape, D. Ginzinger, T. Batchelor, P. Treseler, M. Berger, M. McDermott, M. Prados, et al. Gene expression and angiotropism in primary CNS lymphoma Blood, May 1, 2006; 107(9): 3716 - 3723. [Abstract] [Full Text] [PDF] L. M. DeAngelis and F. M. Iwamoto An Update on Therapy of Primary Central Nervous System Lymphoma Hematology, January 1, 2006; 2006(1): 311 - 316. [Abstract] [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020