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Blood, 1 January 2006, Vol. 107, No. 1, pp. 213-221. Prepublished online as a Blood First Edition Paper on September 13, 2005; DOI 10.1182/blood-2005-06-2273. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-06-2273v1 107/1/213    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tedoldi, S. Articles by Horejsí, V. Search for Related Content PubMed PubMed Citation Articles by Tedoldi, S. Articles by Horejsí, V. Related Collections Signal Transduction Immunobiology Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Transmembrane adaptor molecules: a new category of lymphoid-cell markers Sara Tedoldi, Jennifer C. Paterson, Martin-Leo Hansmann, Yasodha Natkunam, Thomas Rüdiger, Pavla Angelisova, Ming Q. Du, Helen Roberton, Giovanna Roncador, Lydia Sanchez, Michela Pozzobon, Noraidah Masir, Richard Barry, Stefano Pileri, David Y. Mason, Teresa Marafioti, and Václav Horejsí From the Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom; Senckenberg Pathology Institute, Johann Wolfgang Goethe-University Clinic Frankfurt AM Main, Frankfurt AM Main, Germany; Department of Pathology, Stanford University School of Medicine, Stanford, CA; Institute of Pathology, University of Würzburg, Würzburg, Germany; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; National Center for the Investigation of Oncology, Monoclonal Antibodies Unit, Biotechnology Program, Madrid, Spain; and Department of Pathology and Unit of Haematopathology, "L & A Seragnoli" Institute of Haematology, University of Bologna, Bologna, Italy. Transmembrane adaptor proteins (of which 7 have been identified so far) are involved in receptor signaling in immune cells. They have only a short extracellular region, with most of the molecule comprising a substantial intracytoplasmic region carrying multiple tyrosine residues that can be phosphorylated by Src- or Syk-family kinases. In this paper, we report an immunohistologic study of 6 of these molecules in normal and neoplastic human tissue sections and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT). Their expression in neoplastic lymphoid cells broadly reflects that of normal lymphoid tissue, including the positivity of plasma cells and myeloma/plasmacytoma for LIME, NTAL, PAG, and SIT. However, this study also revealed some reactions that may be of diagnostic/prognostic value. For example, lymphocytic lymphoma and mantle-cell lymphoma showed similar profiles but differed clearly from follicle-center lymphoma, whereas PAG tended to be selectively expressed in germinal center-derived subsets of diffuse large B-cell lymphoma. These molecules represent a potentially important addition to the panel of immunophenotypic markers detectable in routine biopsies that can be used in hematopathologic studies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Marafioti, J. C. Paterson, E. Ballabio, K. K. Reichard, S. Tedoldi, K. Hollowood, M. Dictor, M.-L. Hansmann, S. A. Pileri, M. J. Dyer, et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells Blood, April 1, 2008; 111(7): 3778 - 3792. [Abstract] [Full Text] [PDF] G. Mattsson, S. Y. Tan, D. J.P. Ferguson, W. Erber, S. H. Turner, T. Marafioti, and D. Y. Mason Detection of Genetic Alterations by ImmunoFISH Analysis of Whole Cells Extracted from Routine Biopsy Material J. Mol. Diagn., September 1, 2007; 9(4): 479 - 489. [Abstract] [Full Text] [PDF] Y. Natkunam, G. Vainer, J. Chen, S. Zhao, R. J. Marinelli, A. S. Hammer, S. Hamilton-Dutoit, E. Pikarsky, G. Amir, R. Levy, et al. Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms Haematologica, February 1, 2007; 92(2): 176 - 183. [Abstract] [Full Text] [PDF] I. H. Khan, S. Mendoza, P. Rhyne, M. Ziman, J. Tuscano, D. Eisinger, H.-J. Kung, and P. A. Luciw Multiplex Analysis of Intracellular Signaling Pathways in Lymphoid Cells by Microbead Suspension Arrays Mol. Cell. Proteomics, April 1, 2006; 5(4): 758 - 768. [Abstract] [Full Text] [PDF]

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