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Blood, 1 January 2006, Vol. 107, No. 1, pp. 30-38. Prepublished online as a Blood First Edition Paper on July 26, 2005; DOI 10.1182/blood-2005-05-1833. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: 2005-05-1833v1 107/1/30    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Noda, S. Articles by Mocarski, E. S. Search for Related Content PubMed PubMed Citation Articles by Noda, S. Articles by Mocarski, E. S. Related Collections Hematopoiesis and Stem Cells Cell Adhesion and Motility Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS Cytomegalovirus MCK-2 controls mobilization and recruitment of myeloid progenitor cells to facilitate dissemination Satoshi Noda, Shirley A. Aguirre, Andrew Bitmansour, Janice M. Brown, Timothy E. Sparer, Jing Huang, and Edward S. Mocarski From the Department of Microbiology and Immunology, and Division of Bone Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA; and the Laboratory for Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa, Japan. Murine cytomegalovirus encodes a secreted, pro-inflammatory chemokine-like protein, MCK-2, that recruits leukocytes and facilitates viral dissemination. We have shown that MCK-2-enhanced recruitment of myelomonocytic leukocytes with an immature phenotype occurs early during infection and is associated with efficient viral dissemination. Expression of MCK-2 drives the mobilization of a population of leukocytes from bone marrow that express myeloid marker Mac-1 (CD11b), intermediate levels of Gr-1 (Ly6 G/C), platelet-endothelial-cell adhesion molecule-1 (PECAM-1, CD31), together with heterogeneous levels of stem-cell antigen-1 (Sca-1, Ly-6 A /E). Recombinant MCK-2 mediates recruitment of this population even in the absence of viral infection. Recruitment of this cell population and viral dissemination via the bloodstream to salivary glands proceeds normally in mice that lack CCR2 and MCP-1 (CCL2), suggesting that recruitment of macrophages is not a requisite component of pathogenesis. Thus, a systemic impact of MCK-2 enhances the normal host response and causes a marked increase in myelomonocytic recruitment with an immature phenotype to initial sites of infection. Mobilization influences levels of virus dissemination via the bloodstream to salivary glands and is dependent on a myelomonocytic cell type other than mature macrophages. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. D. Cardin, G. C. Schaefer, J. R. Allen, N. J. Davis-Poynter, and H. E. Farrell The M33 Chemokine Receptor Homolog of Murine Cytomegalovirus Exhibits a Differential Tissue-Specific Role during In Vivo Replication and Latency J. Virol., August 1, 2009; 83(15): 7590 - 7601. [Abstract] [Full Text] [PDF] J. Dumortier, D. N. Streblow, A. V. Moses, J. M. Jacobs, C. N. Kreklywich, D. Camp, R. D. Smith, S. L. Orloff, and J. A. Nelson Human Cytomegalovirus Secretome Contains Factors That Induce Angiogenesis and Wound Healing J. Virol., July 1, 2008; 82(13): 6524 - 6535. [Abstract] [Full Text] [PDF] J. L. Stern and B. Slobedman Human Cytomegalovirus Latent Infection of Myeloid Cells Directs Monocyte Migration by Up-Regulating Monocyte Chemotactic Protein-1 J. Immunol., May 15, 2008; 180(10): 6577 - 6585. [Abstract] [Full Text] [PDF] D. Stapler, E. D. Lee, S. A. Selvaraj, A. G. Evans, L. S. Kean, S. H. Speck, C. P. Larsen, and S. Gangappa Expansion of Effector Memory TCR V{beta}4+CD8+ T Cells Is Associated with Latent Infection-Mediated Resistance to Transplantation Tolerance J. Immunol., March 1, 2008; 180(5): 3190 - 3200. [Abstract] [Full Text] [PDF]

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