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Blood, 1 January 2006, Vol. 107, No. 1, pp. 389-396. Prepublished online as a Blood First Edition Paper on September 20, 2005; DOI 10.1182/blood-2005-07-2746. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-07-2746v1 107/1/389    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chalandon, Y. Articles by Roosnek, E. Search for Related Content PubMed PubMed Citation Articles by Chalandon, Y. Articles by Roosnek, E. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications Yves Chalandon, Sylvie Degermann, Jean Villard, Lionel Arlettaz, Laurent Kaiser, Solange Vischer, Steffen Walter, Mirjam H. M. Heemskerk, Rene A. W. van Lier, Claudine Helg, Bernard Chapuis, and Eddy Roosnek From the Division of Hematology, the Division of Immunology and Allergology, and the Central Laboratory of Virology, Division of Infectious Diseases, Department of Internal Medicine, University Hospital Geneva, Switzerland; the Institute for Cell Biology, Department of Immunology, Eberhard Karls University, Tübingen, Germany; the Department of Hematology, Leiden University Medical Center (LUMC), The Netherlands; and the Laboratory of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands. We have studied cytomegalovirus (CMV) immunity in 17 CMV-positive recipients of T-cell-depleted or T-cell-replete grafts. In recipients of T-cell-replete grafts, the patient's CMV-specific T-cell response was completely ablated. Because primary anti-CMV responses were rare during the first year, immunity depended essentially on the transfer of donor CMV-specific T cells and, therefore, on the CMV positivity of the donor. In the recipients of T-cell-depleted grafts, CMV-specific cytotoxic T cells were of recipient origin in 2 patients who underwent transplantation with CMV-negative donors and in 3 of 8 patients who underwent transplantation with CMV-positive donors, and they were of mixed or donor origin in the other 5 patients studied. Recipient CMV-specific T cells responded vigorously to antigen ex vivo and persisted for several years without replenishment by donor cells. Furthermore, they appeared to have a protective effect because CMV-related complications were absent in the patients with CMV-specific T cells of recipient origin. Clinical outcomes of a cohort of 91 patients corroborated the experimental results. Patients with recipient T cells in their blood were protected regardless of the donor immune status. Hence, when a T-cell depletion protocol is used that favors the survival of recipient T cells, the patient's pretransplantation CMV-specific immunity protects against posttransplantation CMV-related complications. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. J. C. Miles, M. van der Sande, D. Jeffries, S. Kaye, J. Ismaili, O. Ojuola, M. Sanneh, E. S. Touray, P. Waight, S. Rowland-Jones, et al. Cytomegalovirus Infection in Gambian Infants Leads to Profound CD8 T-Cell Differentiation J. Virol., June 1, 2007; 81(11): 5766 - 5776. [Abstract] [Full Text] [PDF] M. S. Albano, P. Taylor, R. F. Pass, A. Scaradavou, R. Ciubotariu, C. Carrier, L. Dobrila, P. Rubinstein, and C. E. Stevens Umbilical cord blood transplantation and cytomegalovirus: posttransplantation infection and donor screening Blood, December 15, 2006; 108(13): 4275 - 4282. [Abstract] [Full Text] [PDF]

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