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Blood, 15 May 2006, Vol. 107, No. 10, pp. 3841-3846. Prepublished online as a Blood First Edition Paper on January 10, 2006; DOI 10.1182/blood-2005-10-4308. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-10-4308v1 107/10/3841    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Culleton, B. F. Articles by Hemmelgarn, B. R. Search for Related Content PubMed PubMed Citation Articles by Culleton, B. F. Articles by Hemmelgarn, B. R. Related Collections Clinical Trials and Observations Red Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Impact of anemia on hospitalization and mortality in older adults Bruce F. Culleton, Braden J. Manns, Jianguo Zhang, Marcello Tonelli, Scott Klarenbach, and Brenda R. Hemmelgarn From the Department of Medicine, University of Calgary, Calgary, AB; the Alberta Kidney Disease Network, Calgary/Edmonton, AB; the Institute of Health Economics, Edmonton, AB; the Department of Community Health Sciences, University of Calgary, Calgary, AB; and the Department of Medicine, University of Alberta, Edmonton, AB. Although anemia is common in older adults, its prognostic significance is uncertain. A total of 17 030 community-dwelling subjects 66 years and older were identified between July 1 and December 31, 2001, and followed until December 31, 2004. Cox proportional hazards analyses were performed to determine the associations between anemia (defined as hemoglobin < 110 g/L) and hemoglobin and all-cause mortality, all-cause hospitalization, and cardiovascular-specific hospitalization. Overall, there were 1983 deaths and 7278 first hospitalizations. In patients with normal kidney function, adjusting for age, sex, diabetes mellitus, and comorbidity, anemia was associated with an increased risk for death (hazard ratio [HR], 4.29; 95% confidence interval [CI], 3.55-5.12), first all-cause hospitalization (HR, 2.16; 95% CI, 1.88-2.48), and first cardiovascular-specific hospitalization (HR, 2.49; 95% CI, 1.99-3.12). An inverse J-shaped relationship between hemoglobin and all-cause mortality was observed; the lowest risk for mortality occurred at hemoglobin values between 130 to 150 g/L for women and 140 to 170 g/L for men. Anemia is associated with an increased risk for hospitalization and death in community-dwelling older adults. Consideration should be given to redefine "normal" hemoglobin values in the elderly. Clinical trials are also necessary to determine whether anemia correction improves quality or quantity of life in this population. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. V. Patel, T. B. Harris, M. Faulhaber, S. B. Angleman, S. Connelly, D. C. Bauer, L. H. Kuller, A. B. Newman, J. M. Guralnik, and for the Health, Aging, and Body Composition Study Racial variation in the relationship of anemia with mortality and mobility disability among older adults Blood, June 1, 2007; 109(11): 4663 - 4670. [Abstract] [Full Text] [PDF] B. R. Hemmelgarn, B. J. Manns, J. Zhang, M. Tonelli, S. Klarenbach, M. Walsh, B. F. Culleton, and for the Alberta Kidney Disease Network Association between Multidisciplinary Care and Survival for Elderly Patients with Chronic Kidney Disease J. Am. Soc. Nephrol., March 1, 2007; 18(3): 993 - 999. [Abstract] [Full Text] [PDF] B.R. Hemmelgarn, B.F. Culleton, and W.A. Ghali Derivation and validation of a clinical index for prediction of rapid progression of kidney dysfunction QJM, February 1, 2007; 100(2): 87 - 92. [Abstract] [Full Text] [PDF] M. S. Zumberg and C. Leissinger Acquired underproduction anemias ASH Self-Assessment Program, January 1, 2007; 2007(1): 78 - 101. [Full Text] [PDF]

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