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Blood, 15 May 2006, Vol. 107, No. 10, pp. 3940-3949. Prepublished online as a Blood First Edition Paper on January 12, 2006; DOI 10.1182/blood-2005-09-3671. This Article Full Text Full Text (PDF) Supplemental Table and Figure All Versions of this Article: 2005-09-3671v1 107/10/3940    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beyer, M. Articles by Schultze, J. L. Search for Related Content PubMed PubMed Citation Articles by Beyer, M. Articles by Schultze, J. L. Related Collections Immunobiology Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma Marc Beyer, Matthias Kochanek, Thomas Giese, Elmar Endl, Martin R. Weihrauch, Percy A. Knolle, Sabine Classen, and Joachim L. Schultze From the Department of Molecular Tumor Biology and Tumor Immunology and the Clinic I for Internal Medicine, University of Cologne; the Institute of Immunology, University of Heidelberg; and the Institute for Molecular Medicine and Experimental Immunology, University of Bonn, Germany. In solid tumors, leukemias, and lymphomas, increased frequencies of functional CD4+CD25high regulatory T cells (Treg cells) have been previously demonstrated. In healthy individuals, Treg cells consist not only of memory but also of naive T cells, which can undergo peripheral expansion and are characterized by a relative enrichment for autoreactive T-cell receptors. Here, we demonstrate in patients with premalignant monoclonal gammopathy of undetermined significance and patients with multiple myeloma that functional FoxP3+ Treg cells of naive, central, and effector memory phenotype as determined by CCR7 and CD45RA expression are significantly expanded. Low frequencies of T-cell receptor excision circles in naive Treg cells in both healthy controls and multiple myeloma patients point to peripheral expansion as the prominent mechanism of increased frequencies of naive Treg cells in these cancer patients. These findings strongly suggest that the increase of functional Treg cells in cancer patients is a response to the process of malignant transformation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I. Kotsianidis, E. Nakou, I. Bouchliou, A. Tzouvelekis, E. Spanoudakis, P. Steiropoulos, I. Sotiriou, V. Aidinis, D. Margaritis, C. Tsatalas, et al. Global Impairment of CD4+CD25+FOXP3+ Regulatory T Cells in Idiopathic Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., June 15, 2009; 179(12): 1121 - 1130. [Abstract] [Full Text] [PDF] D. Mougiakakos, C. C. Johansson, and R. Kiessling Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death Blood, April 9, 2009; 113(15): 3542 - 3545. [Abstract] [Full Text] [PDF] N Chaput, S Louafi, A Bardier, F Charlotte, J-C Vaillant, F Menegaux, M Rosenzwajg, F Lemoine, D Klatzmann, and J Taieb Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue Gut, April 1, 2009; 58(4): 520 - 529. [Abstract] [Full Text] [PDF] A. Curti, S. Trabanelli, V. Salvestrini, M. Baccarani, and R. M. 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