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Blood, 1 June 2006, Vol. 107, No. 11, pp. 4500-4507.
Prepublished online as a Blood First Edition Paper on February 16, 2006; DOI 10.1182/blood-2005-09-3801.
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NEOPLASIA
Identification of subtype-specific genomic alterations in aggressive adult T-cell leukemia/lymphoma
Aya Oshiro,
Hiroyuki Tagawa,
Koichi Ohshima,
Kennosuke Karube,
Naokuni Uike,
Yukie Tashiro,
Atae Utsunomiya,
Masato Masuda,
Nobuyuki Takasu,
Shigeo Nakamura,
Yasuo Morishima, and
Masao Seto
From the Division of Molecular Medicine and Division of Hematology and Cell Therapy, Aichi Cancer Center Institute, Nagoya, Aichi; Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka; Department of Hematology, National Kyushu Cancer Center, Fukuoka; Department of Pathology, Imakiire General Hospital, Kagoshima; Department of Hematology, Imamura Bun-in Hospital, Kagoshima; Second Department of Internal Medicine, University Hospital, University of the Ryukyus, Nishihara, Okinawa; and Pathology/Clinical Laboratories, Nagoya University Hospital, Nagoya, Aichi, Japan.
Aggressive adult T-cell leukemia/lymphoma (ATLL) such as acute and lymphoma types are fatal diseases with poor prognosis. Although these 2 subtypes feature different clinicopathologic characteristics, no detailed comparative analyses of genomic/genetic alterations have been reported. We performed array-based comparative genomic hybridization for 17 acute and 49 lymphoma cases as well as real-time quantitative polymerase chain reaction (PCR) to identify the target genes of recurrently amplified regions. Comparison of the genome profiles of acute and lymphoma types revealed that the lymphoma type had significantly more frequent gains at 1q, 2p, 4q, 7p, and 7q, and losses of 10p, 13q, 16q, and 18p, whereas the acute type showed a gain of 3/3p. Of the recurrent high-level amplifications found at 1p36, 6p25, 7p22, 7q, and 14q32 in the lymphoma type, we were able to demonstrate that CARMA1 is a possible target gene of the 7p22 amplification for the lymphoma type but not for the acute type. Furthermore, we found BCL11B overexpression in the acute type regardless of the 14q32 gain/amplification, but no or low expression of the gene in the lymphoma type. These results suggest that acute and lymphoma types are genomically distinct subtypes, and thus may develop tumors via distinct genetic pathways.
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