Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
Blood, 15 June 2006, Vol. 107, No. 12, pp. 4781-4789.
Prepublished online as a Blood First Edition Paper on February 7, 2006; DOI 10.1182/blood-2005-12-4818.


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2005-12-4818v1
107/12/4781    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Betts, M. R.
Right arrow Articles by Koup, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Betts, M. R.
Right arrow Articles by Koup, R. A.
Related Collections
Right arrow Immunobiology
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

IMMUNOBIOLOGY

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

Michael R. Betts, Martha C. Nason, Sadie M. West, Stephen C. De Rosa, Stephen A. Migueles, Jonathan Abraham, Michael M. Lederman, Jose M. Benito, Paul A. Goepfert, Mark Connors, Mario Roederer, and Richard A. Koup

From the Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD; Biostatistics Research Branch, NIAID, NIH, Bethesda, MD; ImmunoTechnology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD; Center for AIDS Research, Department of Medicine, Case Western Reserve University, Cleveland, OH; Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain; and Department of Medicine, University of Alabama at Birmingham.

Establishing a CD8+ T cell–mediated immune correlate of protection in HIV disease is crucial to the development of vaccines designed to generate cell-mediated immunity. Historically, neither the quantity nor breadth of the HIV-specific CD8+ T-cell response has correlated conclusively with protection. Here, we assess the quality of the HIV-specific CD8+ T-cell response by measuring 5 CD8+ T-cell functions (degranulation, IFN-{gamma}, MIP-1beta, TNF-{alpha}, and IL-2) simultaneously in chronically HIV-infected individuals and elite nonprogressors. We find that the functional profile of HIV-specific CD8+ T cells in progressors is limited compared to that of nonprogressors, who consistently maintain highly functional CD8+ T cells. This limited functionality is independent of HLA type and T-cell memory phenotype, is HIV-specific rather than generalized, and is not effectively restored by therapeutic intervention. Whereas the total HIV-specific CD8+ T-cell frequency did not correlate with viral load, the frequency and proportion of the HIV-specific T-cell response with highest functionality inversely correlated with viral load in the progressors. Thus, rather than quantity or phenotype, the quality of the CD8+ T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
Proc R Soc BHome page
H. R. Fryer, A. Scherer, A. Oxenius, R. Phillips, and A. R. McLean
No evidence for competition between cytotoxic T-lymphocyte responses in HIV-1 infection
Proc R Soc B, December 22, 2009; 276(1677): 4389 - 4397.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
S. A. Migueles, K. A. Weeks, E. Nou, A. M. Berkley, J. E. Rood, C. M. Osborne, C. W. Hallahan, N. A. Cogliano-Shutta, J. A. Metcalf, M. McLaughlin, et al.
Defective Human Immunodeficiency Virus-Specific CD8+ T-Cell Polyfunctionality, Proliferation, and Cytotoxicity Are Not Restored by Antiretroviral Therapy
J. Virol., November 15, 2009; 83(22): 11876 - 11889.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
T. K. Kim, L. S. St. John, E. D. Wieder, J. Khalili, Q. Ma, and K. V. Komanduri
Human Late Memory CD8+ T Cells Have a Distinct Cytokine Signature Characterized by CC Chemokine Production without IL-2 Production
J. Immunol., November 15, 2009; 183(10): 6167 - 6174.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
V. D. Gonzalez, K. Falconer, N. K. Bjorkstrom, K. G. Blom, O. Weiland, H.-G. Ljunggren, A. Alaeus, and J. K. Sandberg
Expansion of Functionally Skewed CD56-Negative NK Cells in Chronic Hepatitis C Virus Infection: Correlation with Outcome of Pegylated IFN-{alpha} and Ribavirin Treatment
J. Immunol., November 15, 2009; 183(10): 6612 - 6618.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A.-S. Beignon, K. Mollier, C. Liard, F. Coutant, S. Munier, J. Riviere, P. Souque, and P. Charneau
Lentiviral Vector-Based Prime/Boost Vaccination against AIDS: Pilot Study Shows Protection against Simian Immunodeficiency Virus SIVmac251 Challenge in Macaques
J. Virol., November 1, 2009; 83(21): 10963 - 10974.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
A. Zloza, J. M. Schenkel, A. R. Tenorio, J. A. Martinson, P. M. Jeziorczak, and L. Al-Harthi
Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface
Blood, October 29, 2009; 114(18): 3841 - 3853.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
Y. Sun, R. T. Bailer, S. S. Rao, J. R. Mascola, G. J. Nabel, R. A. Koup, and N. L. Letvin
Systemic and Mucosal T-Lymphocyte Activation Induced by Recombinant Adenovirus Vaccines in Rhesus Monkeys
J. Virol., October 15, 2009; 83(20): 10596 - 10604.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
L. H. Haut and H. C. J. Ertl
Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine
J. Leukoc. Biol., October 1, 2009; 86(4): 779 - 793.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. Piantadosi, D. Panteleeff, C. A. Blish, J. M. Baeten, W. Jaoko, R. S. McClelland, and J. Overbaugh
Breadth of Neutralizing Antibody Response to Human Immunodeficiency Virus Type 1 Is Affected by Factors Early in Infection but Does Not Influence Disease Progression
J. Virol., October 1, 2009; 83(19): 10269 - 10274.
[Abstract] [Full Text] [PDF]


Home page
CVIHome page
X.-L. Huang, Z. Fan, L. Borowski, and C. R. Rinaldo
Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells
Clin. Vaccine Immunol., October 1, 2009; 16(10): 1504 - 1516.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
M. L. Brantly, J. D. Chulay, L. Wang, C. Mueller, M. Humphries, L. T. Spencer, F. Rouhani, T. J. Conlon, R. Calcedo, M. R. Betts, et al.
Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy
PNAS, September 22, 2009; 106(38): 16363 - 16368.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
F. Mingozzi, J. J. Meulenberg, D. J. Hui, E. Basner-Tschakarjan, N. C. Hasbrouck, S. A. Edmonson, N. A. Hutnick, M. R. Betts, J. J. Kastelein, E. S. Stroes, et al.
AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells
Blood, September 3, 2009; 114(10): 2077 - 2086.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
B. T. Korber, N. L. Letvin, and B. F. Haynes
T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
J. Virol., September 1, 2009; 83(17): 8300 - 8314.
[Full Text] [PDF]


Home page
J. Virol.Home page
J. J. Chang, S. Sirivichayakul, A. Avihingsanon, A. J. V. Thompson, P. Revill, D. Iser, J. Slavin, S. Buranapraditkun, P. Marks, G. Matthews, et al.
Impaired Quality of the Hepatitis B Virus (HBV)-Specific T-Cell Response in Human Immunodeficiency Virus Type 1-HBV Coinfection
J. Virol., August 1, 2009; 83(15): 7649 - 7658.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
C. Petrovas, B. Chaon, D. R. Ambrozak, D. A. Price, J. J. Melenhorst, B. J. Hill, C. Geldmacher, J. P. Casazza, P. K. Chattopadhyay, M. Roederer, et al.
Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection
J. Immunol., July 15, 2009; 183(2): 1120 - 1132.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
E. Nou, Y. Zhou, D. D. Nou, and J. N. Blankson
Effective Downregulation of HLA-A*2 and HLA-B*57 by Primary Human Immunodeficiency Virus Type 1 Isolates Cultured from Elite Suppressors
J. Virol., July 1, 2009; 83(13): 6941 - 6946.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
J. C. Engram, R. M. Dunham, G. Makedonas, T. H. Vanderford, B. Sumpter, N. R. Klatt, S. J. Ratcliffe, S. Garg, M. Paiardini, M. McQuoid, et al.
Vaccine-Induced, Simian Immunodeficiency Virus-Specific CD8+ T Cells Reduce Virus Replication but Do Not Protect from Simian Immunodeficiency Virus Disease Progression
J. Immunol., July 1, 2009; 183(1): 706 - 717.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
W. Zhou, J. Longmate, S. F. Lacey, J. M. Palmer, G. Gallez-Hawkins, L. Thao, R. Spielberger, R. Nakamura, S. J. Forman, J. A. Zaia, et al.
Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients
Blood, June 18, 2009; 113(25): 6465 - 6476.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
J. R. Almeida, D. Sauce, D. A. Price, L. Papagno, S. Y. Shin, A. Moris, M. Larsen, G. Pancino, D. C. Douek, B. Autran, et al.
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
Blood, June 18, 2009; 113(25): 6351 - 6360.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
B. A. Colleton, X.-L. Huang, N. M. Melhem, Z. Fan, L. Borowski, G. Rappocciolo, and C. R. Rinaldo
Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells
J. Virol., June 15, 2009; 83(12): 6288 - 6299.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
A. Saez-Cirion, M. Sinet, S. Y. Shin, A. Urrutia, P. Versmisse, C. Lacabaratz, F. Boufassa, V. Avettand-Fenoel, C. Rouzioux, J.-F. Delfraissy, et al.
Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses
J. Immunol., June 15, 2009; 182(12): 7828 - 7837.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
Z. L. Brumme and B. D. Walker
Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification
J. Exp. Med., June 8, 2009; 206(6): 1215 - 1218.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
T. Yamamoto, N. Iwamoto, H. Yamamoto, T. Tsukamoto, T. Kuwano, A. Takeda, M. Kawada, Y. Tsunetsugu-Yokota, and T. Matano
Polyfunctional CD4+ T-Cell Induction in Neutralizing Antibody-Triggered Control of Simian Immunodeficiency Virus Infection
J. Virol., June 1, 2009; 83(11): 5514 - 5524.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. J. Cayabyab, B. Korioth-Schmitz, Y. Sun, A. Carville, H. Balachandran, A. Miura, K. R. Carlson, A. P. Buzby, B. F. Haynes, W. R. Jacobs, et al.
Recombinant Mycobacterium bovis BCG Prime-Recombinant Adenovirus Boost Vaccination in Rhesus Monkeys Elicits Robust Polyfunctional Simian Immunodeficiency Virus-Specific T-Cell Responses
J. Virol., June 1, 2009; 83(11): 5505 - 5513.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
P. Mooij, S. S. Balla-Jhagjhoorsingh, N. Beenhakker, P. van Haaften, I. Baak, I. G. Nieuwenhuis, S. Heidari, H. Wolf, M.-J. Frachette, K. Bieler, et al.
Comparison of Human and Rhesus Macaque T-Cell Responses Elicited by Boosting with NYVAC Encoding Human Immunodeficiency Virus Type 1 Clade C Immunogens
J. Virol., June 1, 2009; 83(11): 5881 - 5889.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
S. Rahman, B. Gudetta, J. Fink, A. Granath, S. Ashenafi, A. Aseffa, M. Derbew, M. Svensson, J. Andersson, and S. G. Brighenti
Compartmentalization of Immune Responses in Human Tuberculosis: Few CD8+ Effector T Cells but Elevated Levels of FoxP3+ Regulatory T Cells in the Granulomatous Lesions
Am. J. Pathol., June 1, 2009; 174(6): 2211 - 2224.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
K. A. O'Connell, Y. Han, T. M. Williams, R. F. Siliciano, and J. N. Blankson
Role of Natural Killer Cells in a Cohort of Elite Suppressors: Low Frequency of the Protective KIR3DS1 Allele and Limited Inhibition of Human Immunodeficiency Virus Type 1 Replication In Vitro
J. Virol., May 15, 2009; 83(10): 5028 - 5034.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. Tatsis, M. O. Lasaro, S.-W. Lin, Z. Q. Xiang, D. Zhou, L. DiMenna, H. Li, A. Bian, S. Abdulla, Y. Li, et al.
Adenovirus Vector-Induced Immune Responses in Nonhuman Primates: Responses to Prime Boost Regimens
J. Immunol., May 15, 2009; 182(10): 6587 - 6599.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. P. J. M. van Gisbergen, R. W. van Olffen, J. van Beek, K. F. van der Sluijs, R. Arens, M. A. Nolte, and R. A. van Lier
Protective CD8 T Cell Memory Is Impaired during Chronic CD70-Driven Costimulation
J. Immunol., May 1, 2009; 182(9): 5352 - 5362.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
A. L. Ferre, P. W. Hunt, J. W. Critchfield, D. H. Young, M. M. Morris, J. C. Garcia, R. B. Pollard, H. F. Yee Jr, J. N. Martin, S. G. Deeks, et al.
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune control
Blood, April 23, 2009; 113(17): 3978 - 3989.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
W. A. Burgers, C. Riou, M. Mlotshwa, P. Maenetje, D. de Assis Rosa, J. Brenchley, K. Mlisana, D. C. Douek, R. Koup, M. Roederer, et al.
Association of HIV-Specific and Total CD8+ T Memory Phenotypes in Subtype C HIV-1 Infection with Viral Set Point
J. Immunol., April 15, 2009; 182(8): 4751 - 4761.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
C. R. Sander, A. A. Pathan, N. E. R. Beveridge, I. Poulton, A. Minassian, N. Alder, J. Van Wijgerden, A. V. S. Hill, F. V. Gleeson, R. J. O. Davies, et al.
Safety and Immunogenicity of a New Tuberculosis Vaccine, MVA85A, in Mycobacterium tuberculosis-infected Individuals
Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 724 - 733.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
D. A. Price, T. E. Asher, N. A. Wilson, M. C. Nason, J. M. Brenchley, I. S. Metzler, V. Venturi, E. Gostick, P. K. Chattopadhyay, M. Roederer, et al.
Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infection
J. Exp. Med., April 13, 2009; 206(4): 923 - 936.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
C. Lecuroux, I. Girault, A. Urrutia, J.-M. Doisne, C. Deveau, C. Goujard, L. Meyer, M. Sinet, and A. Venet
Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection
Blood, April 2, 2009; 113(14): 3209 - 3217.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
H. Chen, A. Piechocka-Trocha, T. Miura, M. A. Brockman, B. D. Julg, B. M. Baker, A. C. Rothchild, B. L. Block, A. Schneidewind, T. Koibuchi, et al.
Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes
J. Virol., April 1, 2009; 83(7): 3138 - 3149.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. Harari, F. B. Enders, C. Cellerai, P.-A. Bart, and G. Pantaleo
Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure
J. Virol., April 1, 2009; 83(7): 2862 - 2871.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. S. Giri, M. Nebozyhn, A. Raymond, B. Gekonge, A. Hancock, S. Creer, C. Nicols, M. Yousef, A. S. Foulkes, K. Mounzer, et al.
Circulating Monocytes in HIV-1-Infected Viremic Subjects Exhibit an Antiapoptosis Gene Signature and Virus- and Host-Mediated Apoptosis Resistance
J. Immunol., April 1, 2009; 182(7): 4459 - 4470.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
T. Miura, M. A. Brockman, A. Schneidewind, M. Lobritz, F. Pereyra, A. Rathod, B. L. Block, Z. L. Brumme, C. J. Brumme, B. Baker, et al.
HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition
J. Virol., March 15, 2009; 83(6): 2743 - 2755.
[Abstract] [Full Text] [PDF]


Home page
J. Gen. Virol.Home page
W. A. Burgers, G. K. Chege, T. L. Muller, J. H. van Harmelen, G. Khoury, E. G. Shephard, C. M. Gray, C. Williamson, and A.-L. Williamson
Broad, high-magnitude and multifunctional CD4+ and CD8+ T-cell responses elicited by a DNA and modified vaccinia Ankara vaccine containing human immunodeficiency virus type 1 subtype C genes in baboons
J. Gen. Virol., February 1, 2009; 90(2): 468 - 480.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
R. D. Mason, S. Alcantara, V. Peut, L. Loh, J. D. Lifson, R. De Rose, and S. J. Kent
Inactivated Simian Immunodeficiency Virus-Pulsed Autologous Fresh Blood Cells as an Immunotherapy Strategy
J. Virol., February 1, 2009; 83(3): 1501 - 1510.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. Duda, L. Lee-Turner, J. Fox, N. Robinson, S. Dustan, S. Kaye, H. Fryer, M. Carrington, M. McClure, A. R. Mclean, et al.
HLA-Associated Clinical Progression Correlates with Epitope Reversion Rates in Early Human Immunodeficiency Virus Infection
J. Virol., February 1, 2009; 83(3): 1228 - 1239.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
E. Carnero, W. Li, A. V. Borderia, B. Moltedo, T. Moran, and A. Garcia-Sastre
Optimization of Human Immunodeficiency Virus Gag Expression by Newcastle Disease Virus Vectors for the Induction of Potent Immune Responses
J. Virol., January 15, 2009; 83(2): 584 - 597.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
J. R. Bailey, T. P. Brennan, K. A. O'Connell, R. F. Siliciano, and J. N. Blankson
Evidence of CD8+ T-Cell-Mediated Selective Pressure on Human Immunodeficiency Virus Type 1 nef in HLA-B*57+ Elite Suppressors
J. Virol., January 1, 2009; 83(1): 88 - 97.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
H. Hatano, E. L. Delwart, P. J. Norris, T.-H. Lee, J. Dunn-Williams, P. W. Hunt, R. Hoh, S. L. Stramer, J. M. Linnen, J. M. McCune, et al.
Evidence for Persistent Low-Level Viremia in Individuals Who Control Human Immunodeficiency Virus in the Absence of Antiretroviral Therapy
J. Virol., January 1, 2009; 83(1): 329 - 335.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
C. M. Gray, M. Mlotshwa, C. Riou, T. Mathebula, D. de Assis Rosa, T. Mashishi, C. Seoighe, N. Ngandu, F. van Loggerenberg, L. Morris, et al.
Human Immunodeficiency Virus-Specific Gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point
J. Virol., January 1, 2009; 83(1): 470 - 478.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
D. G. Brooks, S.-J. Ha, H. Elsaesser, A. H. Sharpe, G. J. Freeman, and M. B. A. Oldstone
IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection
PNAS, December 23, 2008; 105(51): 20428 - 20433.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
S. Huang, J. Dunkley-Thompson, Y. Tang, E. A. Macklin, J. Steel-Duncan, I. Singh-Minott, E. G. Ryland, M. Smikle, B. D. Walker, C. D. C. Christie, et al.
Deficiency of HIV-Gag-Specific T Cells in Early Childhood Correlates with Poor Viral Containment
J. Immunol., December 1, 2008; 181(11): 8103 - 8111.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. Genesca, P. J. Skinner, J. J. Hong, J. Li, D. Lu, M. B. McChesney, and C. J. Miller
With Minimal Systemic T-Cell Expansion, CD8+ T Cells Mediate Protection of Rhesus Macaques Immunized with Attenuated Simian-Human Immunodeficiency Virus SHIV89.6 from Vaginal Challenge with Simian Immunodeficiency Virus
J. Virol., November 15, 2008; 82(22): 11181 - 11196.
[Abstract] [Full Text] [PDF]


Home page
CVIHome page
A. L. Erickson, C. B. Willberg, V. McMahan, A. Liu, S. P. Buchbinder, L. A. Grohskopf, R. M. Grant, and D. F. Nixon
Potentially Exposed but Uninfected Individuals Produce Cytotoxic and Polyfunctional Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Which Can Be Defined to the Epitope Level
Clin. Vaccine Immunol., November 1, 2008; 15(11): 1745 - 1748.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. Lichterfeld, D. Mou, T. D. H. Cung, K. L. Williams, M. T. Waring, J. Huang, F. Pereyra, A. Trocha, G. J. Freeman, E. S. Rosenberg, et al.
Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors
Blood, November 1, 2008; 112(9): 3679 - 3687.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
G. Badr, N. Bedard, M. S. Abdel-Hakeem, L. Trautmann, B. Willems, J.-P. Villeneuve, E. K. Haddad, R. P. Sekaly, J. Bruneau, and N. H. Shoukry
Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells
J. Virol., October 15, 2008; 82(20): 10017 - 10031.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
E. K. Forbes, C. Sander, E. O. Ronan, H. McShane, A. V. S. Hill, P. C. L. Beverley, and E. Z. Tchilian
Multifunctional, High-Level Cytokine-Producing Th1 Cells in the Lung, but Not Spleen, Correlate with Protection against Mycobacterium tuberculosis Aerosol Challenge in Mice
J. Immunol., October 1, 2008; 181(7): 4955 - 4964.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
J. M. Brenchley, M. Paiardini, K. S. Knox, A. I. Asher, B. Cervasi, T. E. Asher, P. Scheinberg, D. A. Price, C. A. Hage, L. M. Kholi, et al.
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
Blood, October 1, 2008; 112(7): 2826 - 2835.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
J. B. Sacha, M. R. Reynolds, M. B. Buechler, C. Chung, A. K. Jonas, L. T. Wallace, A. M. Weiler, W. Lee, S. M. Piaskowski, T. Soma, et al.
Differential Antigen Presentation Kinetics of CD8+ T-Cell Epitopes Derived from the Same Viral Protein
J. Virol., September 15, 2008; 82(18): 9293 - 9298.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. K. Bjorkstrom, V. D. Gonzalez, K.-J. Malmberg, K. Falconer, A. Alaeus, G. Nowak, C. Jorns, B.-G. Ericzon, O. Weiland, J. K. Sandberg, et al.
Elevated Numbers of Fc{gamma}RIIIA+ (CD16+) Effector CD8 T Cells with NK Cell-Like Function in Chronic Hepatitis C Virus Infection
J. Immunol., September 15, 2008; 181(6): 4219 - 4228.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
A. H. Sabouri, K. Usuku, D. Hayashi, S. Izumo, Y. Ohara, M. Osame, and M. Saito
Impaired function of human T-lymphotropic virus type 1 (HTLV-1)-specific CD8+ T cells in HTLV-1-associated neurologic disease
Blood, September 15, 2008; 112(6): 2411 - 2420.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
Y. Enose-Akahata, U. Oh, C. Grant, and S. Jacobson
Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease
Blood, September 15, 2008; 112(6): 2400 - 2410.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. J. Chase, H.-C. Yang, H. Zhang, J. N. Blankson, and R. F. Siliciano
Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4+ T-Cell Activation
J. Virol., September 1, 2008; 82(17): 8307 - 8315.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
Y. Sun, S. Santra, J. E. Schmitz, M. Roederer, and N. L. Letvin
Magnitude and Quality of Vaccine-Elicited T-Cell Responses in the Control of Immunodeficiency Virus Replication in Rhesus Monkeys
J. Virol., September 1, 2008; 82(17): 8812 - 8819.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
J. W. Wells, C. J. Cowled, F. Farzaneh, and A. Noble
Combined Triggering of Dendritic Cell Receptors Results in Synergistic Activation and Potent Cytotoxic Immunity
J. Immunol., September 1, 2008; 181(5): 3422 - 3431.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
K. S. Cox, J. H. Clair, M. T. Prokop, K. J. Sykes, S. A. Dubey, J. W. Shiver, M. N. Robertson, and D. R. Casimiro
DNA gag/Adenovirus Type 5 (Ad5) gag and Ad5 gag/Ad5 gag Vaccines Induce Distinct T-Cell Response Profiles
J. Virol., August 15, 2008; 82(16): 8161 - 8171.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
H. Streeck, B. Li, A. F.Y. Poon, A. Schneidewind, A. D. Gladden, K. A. Power, D. Daskalakis, S. Bazner, R. Zuniga, C. Brander, et al.
Immune-driven recombination and loss of control after HIV superinfection
J. Exp. Med., August 4, 2008; 205(8): 1789 - 1796.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
J. D. Lunemann, I. Jelcic, S. Roberts, A. Lutterotti, B. Tackenberg, R. Martin, and C. Munz
EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-{gamma} and IL-2
J. Exp. Med., August 4, 2008; 205(8): 1763 - 1773.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
J. R. Bailey, K. O'Connell, H.-C. Yang, Y. Han, J. Xu, B. Jilek, T. M. Williams, S. C. Ray, R. F. Siliciano, and J. N. Blankson
Transmission of Human Immunodeficiency Virus Type 1 from a Patient Who Developed AIDS to an Elite Suppressor
J. Virol., August 1, 2008; 82(15): 7395 - 7410.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
A. Bansal, B. Jackson, K. West, S. Wang, S. Lu, J. S. Kennedy, and P. A. Goepfert
Multifunctional T-Cell Characteristics Induced by a Polyvalent DNA Prime/Protein Boost Human Immunodeficiency Virus Type 1 Vaccine Regimen Given to Healthy Adults Are Dependent on the Route and Dose of Administration
J. Virol., July 1, 2008; 82(13): 6458 - 6469.
[Abstract] [Full Text] [PDF]


Home page
CVIHome page
C. C. Wilson, M. J. Newman, B. D. Livingston, S. MaWhinney, J. E. Forster, J. Scott, R. T. Schooley, and C. A. Benson
Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy
Clin. Vaccine Immunol., June 1, 2008; 15(6): 986 - 994.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
B. Emu, E. Sinclair, H. Hatano, A. Ferre, B. Shacklett, J. N. Martin, J. M. McCune, and S. G. Deeks
HLA Class I-Restricted T-Cell Responses May Contribute to the Control of Human Immunodeficiency Virus Infection, but Such Responses Are Not Always Necessary for Long-Term Virus Control
J. Virol., June 1, 2008; 82(11): 5398 - 5407.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
N. J. Maness, L. J. Yant, C. Chung, J. T. Loffredo, T. C. Friedrich, S. M. Piaskowski, J. Furlott, G. E. May, T. Soma, E. J. Leon, et al.
Comprehensive Immunological Evaluation Reveals Surprisingly Few Differences between Elite Controller and Progressor Mamu-B*17-Positive Simian Immunodeficiency Virus-Infected Rhesus Macaques
J. Virol., June 1, 2008; 82(11): 5245 - 5254.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
J. Liu, B. A. Ewald, D. M. Lynch, M. Denholtz, P. Abbink, A. A. C. Lemckert, A. Carville, K. G. Mansfield, M. J. Havenga, J. Goudsmit, et al.
Magnitude and Phenotype of Cellular Immune Responses Elicited by Recombinant Adenovirus Vectors and Heterologous Prime-Boost Regimens in Rhesus Monkeys
J. Virol., May 15, 2008; 82(10): 4844 - 4852.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. Daucher, D. A. Price, J. M. Brenchley, L. Lamoreaux, J. A. Metcalf, C. Rehm, E. Nies-Kraske, E. Urban, C. Yoder, D. Rock, et al.
Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells
J. Virol., April 15, 2008; 82(8): 4102 - 4114.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
D. Verhoeven, S. Sankaran, M. Silvey, and S. Dandekar
Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4+ T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells
J. Virol., April 15, 2008; 82(8): 4016 - 4027.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
M. Rehr, J. Cahenzli, A. Haas, D. A. Price, E. Gostick, M. Huber, U. Karrer, and A. Oxenius
Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy
J. Virol., April 1, 2008; 82(7): 3391 - 3404.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
E. R. Van Gulck, G. Vanham, L. Heyndrickx, S. Coppens, K. Vereecken, D. Atkinson, E. Florence, I. Kint, Z. N. Berneman, and V. V. Tendeloo
Efficient In Vitro Expansion of Human Immunodeficiency Virus (HIV)-Specific T-Cell Responses by gag mRNA-Electroporated Dendritic Cells from Treated and Untreated HIV Type 1-Infected Individuals
J. Virol., April 1, 2008; 82(7): 3561 - 3573.
[Abstract] [Full Text] [PDF]


Home page
CVIHome page
C. Nilsson, S. Aboud, K. Karlen, B. Hejdeman, W. Urassa, and G. Biberfeld
Optimal Blood Mononuclear Cell Isolation Procedures for Gamma Interferon Enzyme-Linked Immunospot Testing of Healthy Swedish and Tanzanian Subjects
Clin. Vaccine Immunol., April 1, 2008; 15(4): 585 - 589.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
P. Mooij, S. S. Balla-Jhagjhoorsingh, G. Koopman, N. Beenhakker, P. van Haaften, I. Baak, I. G. Nieuwenhuis, I. Kondova, R. Wagner, H. Wolf, et al.
Differential CD4+ versus CD8+ T-Cell Responses Elicited by Different Poxvirus-Based Human Immunodeficiency Virus Type 1 Vaccine Candidates Provide Comparable Efficacies in Primates
J. Virol., March 15, 2008; 82(6): 2975 - 2988.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
G. Turk, M. M. Gherardi, N. Laufer, M. Saracco, R. Luzzi, J. H. Cox, P. Cahn, and H. Salomon
Magnitude, Breadth, and Functional Profile of T-Cell Responses during Human Immunodeficiency Virus Primary Infection with B and BF Viral Variants
J. Virol., March 15, 2008; 82(6): 2853 - 2866.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
P. J. Holst, M. R. Sorensen, C. M. Mandrup Jensen, C. Orskov, A. R. Thomsen, and J. P. Christensen
MHC Class II-Associated Invariant Chain Linkage of Antigen Dramatically Improves Cell-Mediated Immunity Induced by Adenovirus Vaccines
J. Immunol., March 1, 2008; 180(5): 3339 - 3346.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. J. Smithey, S. Brandt, N. E. Freitag, D. E. Higgins, and H. G. A. Bouwer
Stimulation of Enhanced CD8 T Cell Responses Following Immunization with a Hyper-Antigen Secreting Intracytosolic Bacterial Pathogen
J. Immunol., March 1, 2008; 180(5): 3406 - 3416.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
A. P. Soares, T. J. Scriba, S. Joseph, R. Harbacheuski, R. A. Murray, S. J. Gelderbloem, A. Hawkridge, G. D. Hussey, H. Maecker, G. Kaplan, et al.
Bacillus Calmette-Guerin Vaccination of Human Newborns Induces T Cells with Complex Cytokine and Phenotypic Profiles
J. Immunol., March 1, 2008; 180(5): 3569 - 3577.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
A. Guihot, E. Oksenhendler, L. Galicier, A.-G. Marcelin, L. Papagno, A.-S. Bedin, F. Agbalika, N. Dupin, J. Cadranel, B. Autran, et al.
Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells
Blood, February 1, 2008; 111(3): 1387 - 1395.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
R.-P. Sekaly
The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development?
J. Exp. Med., January 21, 2008; 205(1): 7 - 12.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
A. Harari, P.-A. Bart, W. Stohr, G. Tapia, M. Garcia, E. Medjitna-Rais, S. Burnet, C. Cellerai, O. Erlwein, T. Barber, et al.
An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses
J. Exp. Med., January 21, 2008; 205(1): 63 - 77.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
I. Karlsson, B. Malleret, P. Brochard, B. Delache, J. Calvo, R. Le Grand, and B. Vaslin
Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques
J. Virol., December 15, 2007; 81(24): 13456 - 13468.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
S. J. Potter, C. Lacabaratz, O. Lambotte, S. Perez-Patrigeon, B. Vingert, M. Sinet, J.-H. Colle, A. Urrutia, D. Scott-Algara, F. Boufassa, et al.
Preserved Central Memory and Activated Effector Memory CD4+ T-Cell Subsets in Human Immunodeficiency Virus Controllers: an ANRS EP36 Study
J. Virol., December 15, 2007; 81(24): 13904 - 13915.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
C. Wang, T. Wen, J.-P. Routy, N. F. Bernard, R. P. Sekaly, and T. H. Watts
4-1BBL Induces TNF Receptor-Associated Factor 1-Dependent Bim Modulation in Human T Cells and Is a Critical Component in the Costimulation-Dependent Rescue of Functionally Impaired HIV-Specific CD8 T Cells
J. Immunol., December 15, 2007; 179(12): 8252 - 8263.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
C. F. Thobakgale, D. Ramduth, S. Reddy, N. Mkhwanazi, C. de Pierres, E. Moodley, W. Mphatswe, N. Blanckenberg, A. Cengimbo, A. Prendergast, et al.
Human Immunodeficiency Virus-Specific CD8+ T-Cell Activity Is Detectable from Birth in the Majority of In Utero-Infected Infants
J. Virol., December 1, 2007; 81(23): 12775 - 12784.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
C. Stahl-Hennig, S. Kuate, M. Franz, Y. S. Suh, H. Stoiber, U. Sauermann, K. Tenner-Racz, S. Norley, K. S. Park, Y. C. Sung, et al.
Atraumatic Oral Spray Immunization with Replication-Deficient Viral Vector Vaccines
J. Virol., December 1, 2007; 81(23): 13180 - 13190.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
M. Lichterfeld, D. G. Kavanagh, K. L. Williams, B. Moza, S. K. Mui, T. Miura, R. Sivamurthy, R. Allgaier, F. Pereyra, A. Trocha, et al.
A viral CTL escape mutation leading to immunoglobulin-like transcript 4 mediated functional inhibition of myelomonocytic cells
J. Exp. Med., November 26, 2007; 204(12): 2813 - 2824.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
N. Frahm, D. E. Kaufmann, K. Yusim, M. Muldoon, C. Kesmir, C. H. Linde, W. Fischer, T. M. Allen, B. Li, B. H. McMahon, et al.
Increased Sequence Diversity Coverage Improves Detection of HIV-Specific T Cell Responses
J. Immunol., November 15, 2007; 179(10): 6638 - 6650.
[Abstract] [Full Text] [PDF]


Home page
Infect. Immun.Home page
J. Andersson, A. Samarina, J. Fink, S. Rahman, and S. Grundstrom
Impaired Expression of Perforin and Granulysin in CD8+ T Cells at the Site of Infection in Human Chronic Pulmonary Tuberculosis
Infect. Immun., November 1, 2007; 75(11): 5210 - 5222.
[Abstract] [Full Text] [PDF]


Home page
J. Virol.Home page
S. Kannanganat, B. G. Kapogiannis, C. Ibegbu, L. Chennareddi, P. Goepfert, H. L. Robinson, J. Lennox, and R. R. Amara
Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines
J. Virol., November 1, 2007; 81(21): 12071 - 12076.
[Abstract] [Full Text] [PDF]



 click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020