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Blood, 15 June 2006, Vol. 107, No. 12, pp. 4807-4816. Prepublished online as a Blood First Edition Paper on February 16, 2006; DOI 10.1182/blood-2005-11-4334. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-11-4334v1 107/12/4807    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Starlets, D. Articles by Shachar, I. Search for Related Content PubMed PubMed Citation Articles by Starlets, D. Articles by Shachar, I. Related Collections Immunobiology Apoptosis Cell Cycle Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival Diana Starlets, Yael Gore, Inbal Binsky, Michal Haran, Nurit Harpaz, Lev Shvidel, Shirly Becker-Herman, Alain Berrebi, and Idit Shachar From the Department of Immunology, the Weizmann Institute of Science, Rehovot, Israel; and the Hematology Institute Kaplan Medical Center, Rehovot, Israel. CD74 is an integral membrane protein that was thought to function mainly as an MHC class II chaperone. However, CD74 was recently shown to have a role as an accessory-signaling molecule. Our studies demonstrated that CD74 regulates B-cell differentiation by inducing a pathway leading to the activation of transcription mediated by the NF-B p65/RelA homodimer and its coactivator, TAFII105. Here, we show that CD74 stimulation with anti-CD74 antibody leads to an induction of a signaling cascade resulting in NF-B activation, entry of the stimulated cells into the S phase, elevation of DNA synthesis, cell division, and augmented expression of BCL-XL. These studies therefore demonstrate that surface CD74 functions as a survival receptor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Kamir, S. Zierow, L. Leng, Y. Cho, Y. Diaz, J. Griffith, C. McDonald, M. Merk, R. A. Mitchell, J. Trent, et al. A Leishmania Ortholog of Macrophage Migration Inhibitory Factor Modulates Host Macrophage Responses J. Immunol., June 15, 2008; 180(12): 8250 - 8261. [Abstract] [Full Text] [PDF] P. J. Holst, M. R. Sorensen, C. M. Mandrup Jensen, C. Orskov, A. R. Thomsen, and J. P. Christensen MHC Class II-Associated Invariant Chain Linkage of Antigen Dramatically Improves Cell-Mediated Immunity Induced by Adenovirus Vaccines J. Immunol., March 1, 2008; 180(5): 3339 - 3346. [Abstract] [Full Text] [PDF] E. C. Attar, D. J. DeAngelo, J. G. Supko, F. D'Amato, D. Zahrieh, A. Sirulnik, M. Wadleigh, K. K. Ballen, S. McAfee, K. B. Miller, et al. Phase I and Pharmacokinetic Study of Bortezomib in Combination with Idarubicin and Cytarabine in Patients with Acute Myelogenous Leukemia Clin. Cancer Res., March 1, 2008; 14(5): 1446 - 1454. [Abstract] [Full Text] [PDF] Y. Gore, D. Starlets, N. Maharshak, S. Becker-Herman, U. Kaneyuki, L. Leng, R. Bucala, and I. Shachar Macrophage Migration Inhibitory Factor Induces B Cell Survival by Activation of a CD74-CD44 Receptor Complex J. Biol. Chem., February 1, 2008; 283(5): 2784 - 2792. [Abstract] [Full Text] [PDF] D. Huang, D. T. Cai, R. Y. R. Chua, D. M. Kemeny, and S. H. Wong Nitric-oxide Synthase 2 Interacts with CD74 and Inhibits Its Cleavage by Caspase during Dendritic Cell Development J. Biol. Chem., January 18, 2008; 283(3): 1713 - 1722. [Abstract] [Full Text] [PDF] V. Muller, D. Viemann, M. Schmidt, N. Endres, S. Ludwig, M. Leverkus, J. Roth, and M. Goebeler Candida albicans Triggers Activation of Distinct Signaling Pathways to Establish a Proinflammatory Gene Expression Program in Primary Human Endothelial Cells J. Immunol., December 15, 2007; 179(12): 8435 - 8445. [Abstract] [Full Text] [PDF] F. Lantner, D. Starlets, Y. Gore, L. Flaishon, A. Yamit-Hezi, R. Dikstein, L. Leng, R. Bucala, Y. Machluf, M. Oren, et al. CD74 induces TAp63 expression leading to B-cell survival Blood, December 15, 2007; 110(13): 4303 - 4311. [Abstract] [Full Text] [PDF] R. Stein, M. J. Mattes, T. M. Cardillo, H. J. Hansen, C.-H. Chang, J. Burton, S. Govindan, and D. M. Goldenberg CD74: A New Candidate Target for the Immunotherapy of B-Cell Neoplasms Clin. Cancer Res., September 15, 2007; 13(18): 5556s - 5563s. [Abstract] [Full Text] [PDF] I. Binsky, M. Haran, D. Starlets, Y. Gore, F. Lantner, N. Harpaz, L. Leng, D. M. Goldenberg, L. Shvidel, A. Berrebi, et al. IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival PNAS, August 14, 2007; 104(33): 13408 - 13413. [Abstract] [Full Text] [PDF] K. L. Meyer-Siegler, K. A. Iczkowski, L. Leng, R. Bucala, and P. L. Vera Inhibition of Macrophage Migration Inhibitory Factor or Its Receptor (CD74) Attenuates Growth and Invasion of DU-145 Prostate Cancer Cells J. Immunol., December 15, 2006; 177(12): 8730 - 8739. [Abstract] [Full Text] [PDF]

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