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Blood, 15 January 2006, Vol. 107, No. 2, pp. 467-472. Prepublished online as a Blood First Edition Paper on September 15, 2005; DOI 10.1182/blood-2005-06-2332. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-06-2332v1 107/2/467    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rosado, M. F. Articles by Lossos, I. S. Search for Related Content PubMed PubMed Citation Articles by Rosado, M. F. Articles by Lossos, I. S. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci Manuel F. Rosado, Gerald E. Byrne, Jr, Feying Ding, Kenneth A. Fields, Phillip Ruiz, Sander R. Dubovy, Gale R. Walker, Arnold Markoe, and Izidore S. Lossos From the Sylvester Comprehensive Cancer Center, Division of HematologyOncology, Department of Medicine, and Division of Biostatistics; Departments of Pathology, Microbiology, Radiation Oncology, and Molecular and Cellular Pharmacology; Department of Pathology, Bascom Palmer Eye Institute, University of Miami, Miami, FL. Non-Hodgkin lymphomas are among the most common primary tumors occurring in the ocular adnexa. Herein, we present a 14-year single-institution experience in 62 patients with primary ocular adnexal lymphomas (OALs). Association with Chlamydia psittaci infection is examined in 57 tumor specimens. Extranodal marginal zone lymphoma (EMZL) was the most frequent histologic subtype (89%). The majority of patients with EMZL (84%) presented with stage E-extranodal (IE), however only 16% had an advanced stage. All stage IE patients were treated with local radiotherapy, whereas patients with disseminated disease received systemic therapy with or without local irradiation. All but 1 patient with EMZL achieved complete remission (CR). During a median follow-up of 52 months (range, 3-153 months), the estimated 5-year overall survival (OS) and freedom from progression (FFP) were 96% and 79%, respectively. During the follow-up, 22% of patients relapsed, mainly in extranodal sites, and 4% transformed to diffuse large B-cell lymphoma. None of the patients exhibited local orbital failure in the radiation field. None of the OAL specimens harbored C psittaci DNA. Our study demonstrates that EMZLs, accounting for the majority of primary OALs, are characterized by an indolent natural history with frequent, continuous extranodal relapses. In South Florida, OALs are not associated with C psittaci infections. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Stefanovic and I. S. Lossos Response: Variability in the prevalence of Chlamydophila psittaci infection in patients with OAML Blood, October 15, 2009; 114(16): 3499 - 3500. [Full Text] [PDF] R. J. Bende, F. van Maldegem, and C. J.M. van Noesel Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas Haematologica, August 1, 2009; 94(8): 1109 - 1123. [Abstract] [Full Text] [PDF] A. Stefanovic and I. S. Lossos Extranodal marginal zone lymphoma of the ocular adnexa Blood, July 16, 2009; 114(3): 501 - 510. [Abstract] [Full Text] [PDF] L. D. Sjo, S. Heegaard, J. U. Prause, B. L. Petersen, S. Pedersen, and E. Ralfkiaer Extranodal Marginal Zone Lymphoma in the Ocular Region: Clinical, Immunophenotypical, and Cytogenetical Characteristics Invest. Ophthalmol. Vis. Sci., February 1, 2009; 50(2): 516 - 522. [Abstract] [Full Text] [PDF] L. D. Sjo, E. Ralfkiaer, J. U. Prause, J. H. Petersen, J. Madsen, N. T. Pedersen, and S. Heegaard Increasing Incidence of Ophthalmic Lymphoma in Denmark from 1980 to 2005 Invest. Ophthalmol. Vis. Sci., August 1, 2008; 49(8): 3283 - 3288. [Abstract] [Full Text] [PDF] V. M L Cohen, J. Sweetenham, and A. D Singh Ocular adnexal lymphoma. What is the evidence for an infectious aetiology? Br J Ophthalmol, April 1, 2008; 92(4): 446 - 448. [Full Text] [PDF] E.-K. Song, S.-Y. Kim, T. M. Kim, K.-W. Lee, T. Yun, I.-I. Na, H. Shin, S. H. Lee, D. W. Kim, S. I. Khwarg, et al. Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma Ann. Onc., February 1, 2008; 19(2): 242 - 246. [Abstract] [Full Text] [PDF] E. Hatef, D. Roberts, P. McLaughlin, B. Pro, and B. Esmaeli Prevalence and Nature of Systemic Involvement and Stage at Initial Examination in Patients With Orbital and Ocular Adnexal Lymphoma Arch Ophthalmol, December 1, 2007; 125(12): 1663 - 1667. [Abstract] [Full Text] [PDF] D.-E. Oh and Y.-D. Kim Lymphoproliferative Diseases of the Ocular Adnexa in Korea Arch Ophthalmol, December 1, 2007; 125(12): 1668 - 1673. [Abstract] [Full Text] [PDF] K. Tanimoto, A. Kaneko, S. Suzuki, N. Sekiguchi, T. Watanabe, Y. Kobayashi, Y. Kagami, A. M. Maeshima, Y. Matsuno, and K. Tobinai Primary Ocular Adnexal MALT Lymphoma: A Long-term Follow-up Study of 114 Patients Jpn. J. Clin. Oncol., June 11, 2007; (2007) hym031v1. [Abstract] [Full Text] [PDF] C. M Bacon, M.-Q. Du, and A. Dogan Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists J. Clin. Pathol., April 1, 2007; 60(4): 361 - 372. [Abstract] [Full Text] [PDF] S. M. Cohen, M. Petryk, M. Varma, P. S. Kozuch, E. D. Ames, and M. L. Grossbard Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue Oncologist, November 1, 2006; 11(10): 1100 - 1117. [Abstract] [Full Text] [PDF] E. Zucca and F. Bertoni Chlamydia or not Chlamydia, that is the question: which is the microorganism associated with MALT lymphomas of the ocular adnexa? J Natl Cancer Inst, October 4, 2006; 98(19): 1348 - 1349. [Full Text] [PDF] D. Decaudin, P. de Cremoux, A. Vincent-Salomon, R. Dendale, and L. L.-L. Rouic Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options Blood, September 1, 2006; 108(5): 1451 - 1460. [Abstract] [Full Text] [PDF] R. Moslehi, S. S. Devesa, C. Schairer, and J. F. Fraumeni Jr. Rapidly Increasing Incidence of Ocular Non-Hodgkin Lymphoma. J Natl Cancer Inst, July 5, 2006; 98(13): 936 - 939. [Abstract] [Full Text] [PDF] F. Suarez, O. Lortholary, O. Hermine, and M. Lecuit Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation Blood, April 15, 2006; 107(8): 3034 - 3044. [Abstract] [Full Text] [PDF]

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