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Blood, 15 January 2006, Vol. 107, No. 2, pp. 835-840. Prepublished online as a Blood First Edition Paper on September 22, 2005; DOI 10.1182/blood-2005-07-2705. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-07-2705v1 107/2/835    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cramer, D. E. Articles by Yan, J. Search for Related Content PubMed PubMed Citation Articles by Cramer, D. E. Articles by Yan, J. Related Collections Hematopoiesis and Stem Cells Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION -Glucan enhances complement-mediated hematopoietic recovery after bone marrow injury Daniel E. Cramer, Daniel J. Allendorf, Jarek T. Baran, Richard Hansen, Jose Marroquin, Bing Li, Janina Ratajczak, Mariusz Z. Ratajczak, and Jun Yan From the Tumor Immunobiology Program and Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY. Myelotoxic injury in the bone marrow (BM) as a consequence of total body irradiation (TBI) or granulocyte colony-stimulating factor (G-CSF) mobilization results in the deposition of iC3b on BM stroma (stroma-iC3b). In the present study, we have examined how stroma-iC3b interacts with hematopoietic progenitor cells (HPCs) and the role of complement (C) and complement receptor 3 (CR3) in BM injury/repair. We demonstrate here that stroma-iC3b tethers HPCs via the inserted (I) domain of HPC complement receptor 3 (CR3, CD11b/CD18, Mac-1). Following irradiation, stroma-iC3b was observed in the presence of purified IgM and normal mouse serum (NMS), but not serum from Rag-2-/- mice, implicating a role for antibody (Ab) and the classic pathway of C activation. Furthermore, a novel role for soluble yeast -glucan, a ligand for the CR3 lectin-like domain (LLD), in the priming of CR3+ HPC is suggested. Soluble yeast -glucan could enhance the proliferation of tethered HPCs, promote leukocyte recovery following sublethal irradiation, and increase the survival of lethally irradiated animals following allogeneic HPC transplantation in a CR3-dependent manner. Taken together, these observations suggest a novel role for C, CR3, and -glucan in the restoration of hematopoiesis following injury. (Blood. 2006;107:835-840) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Lin, E. De Stanchina, X. K. Zhou, Y. She, D. Hoang, S. W. Cheung, B. Cassileth, and S. Cunningham-Rundles Maitake Beta-Glucan Enhances Umbilical Cord Blood Stem Cell Transplantation in the NOD/SCID Mouse Experimental Biology and Medicine, March 1, 2009; 234(3): 342 - 353. [Abstract] [Full Text] [PDF] L. M. Lavigne, X. M. O'Brien, M. Kim, J. W. Janowski, J. E. Albina, and J. S. Reichner Integrin Engagement Mediates the Human Polymorphonuclear Leukocyte Response to a Fungal Pathogen-Associated Molecular Pattern J. Immunol., June 1, 2007; 178(11): 7276 - 7282. [Abstract] [Full Text] [PDF] H. Lin, S. W. Y. Cheung, M. Nesin, B. R. Cassileth, and S. Cunningham-Rundles Enhancement of Umbilical Cord Blood Cell Hematopoiesis by Maitake Beta-Glucan Is Mediated by Granulocyte Colony-Stimulating Factor Production Clin. Vaccine Immunol., January 1, 2007; 14(1): 21 - 27. [Abstract] [Full Text] [PDF] J. Ratajczak, R. Reca, B. Machalinski, J. Maciejewski, M. Laughlin, and M. Z. Ratajczak The Unexpected Role of C3a-C3aR Axis in Maturation of Erythroid Cells - Implications for Pathogenesis of Hypoxia-Related Polycythemias. Blood (ASH Annual Meeting Abstracts), November 16, 2006; 108(11): 651 - 651. [Abstract] [PDF]

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