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Blood, 1 February 2006, Vol. 107, No. 3, pp. 1217-1219. Prepublished online as a Blood First Edition Paper on October 6, 2005; DOI 10.1182/blood-2005-04-1744. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-04-1744v1 107/3/1217    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sachs, U. J. H. Articles by Bux, J. Search for Related Content PubMed PubMed Citation Articles by Sachs, U. J. H. Articles by Bux, J. Related Collections Phagocytes Transfusion Medicine Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSFUSION MEDICINE Brief report Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model Ulrich J. H. Sachs, Katja Hattar, Norbert Weissmann, Rainer M. Bohle, Timo Weiss, Ulf Sibelius, and Juergen Bux From the Institute for Clinical Immunology and Transfusion Medicine, Department of Internal Medicine, and the Department of Pathology, Justus Liebig University, Giessen, Germany; Rudolf Virchow Center for Experimental Biomedicine, Wuerzburg, Germany; and the German Red Cross Blood Service West, Hagen, Germany. Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which they induce TRALI is poorly understood. Therefore, we reproduced TRALI in an ex vivo rat lung model. Our data demonstrate that TRALI induction by antileukocyte antibodies is dependent on the density of the cognate antigen but does not necessarily require leukoagglutinating properties of the antibody or the presence of complement proteins. Rather, antibody-mediated activation of neutrophils seems to initiate TRALI, a process that could be triggered by neutrophil stimulation with fMLP. Antibody-mediated neutrophil activation and subsequent release of reactive oxygen species may thus represent key events in the pathophysiologic cascade that leads to immune TRALI. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: O. Gajic, R. Rana, J. L. Winters, M. Yilmaz, J. L. Mendez, O. B. Rickman, M. M. O'Byrne, L. K. Evenson, M. Malinchoc, S. R. DeGoey, et al. Transfusion-related Acute Lung Injury in the Critically Ill: Prospective Nested Case-Control Study Am. J. Respir. Crit. Care Med., November 1, 2007; 176(9): 886 - 891. [Abstract] [Full Text] [PDF] U. J. H. Sachs, C. L. Andrei-Selmer, A. Maniar, T. Weiss, C. Paddock, V. V. Orlova, E. Y. Choi, P. J. Newman, K. T. Preissner, T. Chavakis, et al. The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31) J. Biol. Chem., August 10, 2007; 282(32): 23603 - 23612. [Abstract] [Full Text] [PDF] C. C. Silliman, B. R. Curtis, P. M. Kopko, S. Y. Khan, M. R. Kelher, R. M. Schuller, B. Sannoh, and D. R. Ambruso Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model Blood, February 15, 2007; 109(4): 1752 - 1755. [Abstract] [Full Text] [PDF] D. J. Triulzi Transfusion-Related Acute Lung Injury: An Update Hematology, January 1, 2006; 2006(1): 497 - 501. [Abstract] [Full Text] [PDF]

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