|
|
Blood, 1 February 2006, Vol. 107, No. 3, pp. 1217-1219.
Prepublished online as a Blood First Edition Paper on October 6, 2005; DOI 10.1182/blood-2005-04-1744.
 Previous Article | Table of Contents | Next Article 
TRANSFUSION MEDICINE
Brief report
Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model
Ulrich J. H. Sachs,
Katja Hattar,
Norbert Weissmann,
Rainer M. Bohle,
Timo Weiss,
Ulf Sibelius, and
Juergen Bux
From the Institute for Clinical Immunology and Transfusion Medicine, Department of Internal Medicine, and the Department of Pathology, Justus Liebig University, Giessen, Germany; Rudolf Virchow Center for Experimental Biomedicine, Wuerzburg, Germany; and the German Red Cross Blood Service West, Hagen, Germany.
Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the United States and United Kingdom. Although leukoagglutinating antibodies have been frequently shown to be associated with the syndrome, the mechanism by which they induce TRALI is poorly understood. Therefore, we reproduced TRALI in an ex vivo rat lung model. Our data demonstrate that TRALI induction by antileukocyte antibodies is dependent on the density of the cognate antigen but does not necessarily require leukoagglutinating properties of the antibody or the presence of complement proteins. Rather, antibody-mediated activation of neutrophils seems to initiate TRALI, a process that could be triggered by neutrophil stimulation with fMLP. Antibody-mediated neutrophil activation and subsequent release of reactive oxygen species may thus represent key events in the pathophysiologic cascade that leads to immune TRALI.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. J. Triulzi
Transfusion-Related Acute Lung Injury: Current Concepts for the Clinician
Anesth. Analg.,
March 1, 2009;
108(3):
770 - 776.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Kelher, T. Masuno, E. E. Moore, S. Damle, X. Meng, Y. Song, X. Liang, J. Niedzinski, S. S. Geier, S. Y. Khan, et al.
Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model
Blood,
February 26, 2009;
113(9):
2079 - 2087.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Gajic, R. Rana, J. L. Winters, M. Yilmaz, J. L. Mendez, O. B. Rickman, M. M. O'Byrne, L. K. Evenson, M. Malinchoc, S. R. DeGoey, et al.
Transfusion-related Acute Lung Injury in the Critically Ill: Prospective Nested Case-Control Study
Am. J. Respir. Crit. Care Med.,
November 1, 2007;
176(9):
886 - 891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. J. H. Sachs, C. L. Andrei-Selmer, A. Maniar, T. Weiss, C. Paddock, V. V. Orlova, E. Y. Choi, P. J. Newman, K. T. Preissner, T. Chavakis, et al.
The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31)
J. Biol. Chem.,
August 10, 2007;
282(32):
23603 - 23612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. C. Silliman, B. R. Curtis, P. M. Kopko, S. Y. Khan, M. R. Kelher, R. M. Schuller, B. Sannoh, and D. R. Ambruso
Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model
Blood,
February 15, 2007;
109(4):
1752 - 1755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Triulzi
Transfusion-Related Acute Lung Injury: An Update
Hematology,
January 1, 2006;
2006(1):
497 - 501.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
