SEARCH:   Advanced

Blood, 1 February 2006, Vol. 107, No. 3, pp. 1230-1232. Prepublished online as a Blood First Edition Paper on October 20, 2005; DOI 10.1182/blood-2005-03-1039. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-03-1039v1 107/3/1230    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cook, M. Articles by Moss, P. Search for Related Content PubMed PubMed Citation Articles by Cook, M. Articles by Moss, P. Related Collections Immunobiology Transplantation Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation Mark Cook, David Briggs, Charles Craddock, Premini Mahendra, Donald Milligan, Christopher Fegan, Philip Darbyshire, Sarah Lawson, Elizabeth Boxall, and Paul Moss From the Department of Haematology, University Hospital Birmingham NHS Foundation Trust, Edgbaston, Birmingham, United Kingdom; Department of Histocompatibility and Immunogenetics, National Blood Service Birmingham, Edgbaston, Birmingham, United Kingdom; CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom; Department of Haematology, Heart of England NHS Foundation Trust, Birmingham, United Kingdom; Department of Haematology, Birmingham Children's Hospital, Birmingham, United Kingdom; and West Midlands Public Health Laboratory, Health Protection Agency, Birmingham, United Kingdom. Reactivation of cytomegalovirus (CMV) is a common complication following allogeneic stem cell transplantation. Genetic determinants in the host and donor that may influence the rate of reactivation are currently unknown. Viral replication is controlled by T cells and natural killer (NK) cells and these share expression of killer immunoglobulin-like receptors (KIRs). We analyzed whether activatory KIRs carried by the donor influenced the subsequent rate of CMV reactivation in the patient. In transplantations involving siblings where both donor and recipient were CMV seropositive, donors with more than one activating KIR gene were associated with a 65% reduction in CMV reactivation. Multivariate analysis confirmed a significantly reduced risk of CMV reactivation in sibling transplantations where the donor had more than one activating KIR. Reduced-intensity transplantation and graft-versus-host disease grade 2 or higher were associated with an increased risk of CMV reactivation. This observation indicates that activating KIRs play an important role in the cellular control of CMV reactivation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Boeckh and P. Ljungman How we treat cytomegalovirus in hematopoietic cell transplant recipients Blood, June 4, 2009; 113(23): 5711 - 5719. [Abstract] [Full Text] [PDF] D. P. Lowe, M. A. Cook, S. J. Bowman, D. C. Briggs, and the UK Sjogren's Interest Group Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome Rheumatology, April 1, 2009; 48(4): 359 - 362. [Abstract] [Full Text] [PDF] L. T. van der Veken, M. Diez Campelo, M. A. W. G. van der Hoorn, R. S. Hagedoorn, H. M. E. van Egmond, J. van Bergen, R. Willemze, J. H. F. Falkenburg, and M. H. M. Heemskerk Functional Analysis of Killer Ig-Like Receptor-Expressing Cytomegalovirus-Specific CD8+ T Cells J. Immunol., January 1, 2009; 182(1): 92 - 101. [Abstract] [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020