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Blood, 1 February 2006, Vol. 107, No. 3, pp. 892-897. Prepublished online as a Blood First Edition Paper on October 4, 2005; DOI 10.1182/blood-2005-07-2781. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-07-2781v1 107/3/892    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhang, M. Articles by Goedert, J. J. Search for Related Content PubMed PubMed Citation Articles by Zhang, M. Articles by Goedert, J. J. Related Collections Clinical Trials and Observations Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia Mingdong Zhang, Philip S. Rosenberg, Deborah L. Brown, Liliana Preiss, Barbara A. Konkle, M. Elaine Eyster, James J. Goedert, for the Second Multicenter Hemophilia Cohort Study From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville MD; the Center for Emerging Infectious Diseases, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR; the University of Texas Health Science Center-Houston, Houston, TX; the Research Triangle Institute, Rockville, MD; the Department of Medicine, Division of Hematology/Oncology, University of Pennsylvania, Philadelphia, PA; and the Department of Medicine, Division of Hematology and Oncology, Pennsylvania State University College of Medicine, Hershey, PA. People with hemophilia were formerly at very high risk of infection with hepatitis C virus (HCV). Approximately 20% of HCV-infected patients spontaneously clear the virus. To identify correlates of spontaneous clearance of HCV, we studied a cohort of HCV-infected hemophilic subjects without human immunodeficiency virus infection who had never been treated with interferon. Plasma HCV RNA was persistently undetectable in 192 (27.0%) of 712 HCV-seropositive subjects. In multivariate analyses, HCV clearance was more likely in subjects infected with HCV at younger age, especially with infection before age 2 years (40.1%) compared with after age 15 years (14.9%, Ptrend < .0001), and with relatively recent infection, especially after 1983 (42.8%) compared with before 1969 (18.2%, Ptrend < .0001). HCV clearance was marginally reduced with African ancestry (19%) and greatly increased with chronic hepatitis B virus (HBV) infection (59.1%, P = .001). Resolved HBV infection, coagulopathy types and severity, types of clotting factor treatment, and sex were not associated with HCV clearance. In conclusion, hemophilic subjects coinfected with chronic HBV and those infected with HCV before age 2 years or after 1983 were significantly more likely to spontaneously clear HCV viremia. These data highlight and clarify the importance of nongenetic determinants in spontaneous recovery from HCV infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. J. Goedert, B. E. Chen, L. Preiss, L. M. Aledort, P. S. Rosenberg, and for the Second Multicenter Hemophilia Cohort Study Reconstruction of the Hepatitis C Virus Epidemic in the US Hemophilia Population, 1940-1990 Am. J. Epidemiol., June 15, 2007; 165(12): 1443 - 1453. [Abstract] [Full Text] [PDF]

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