SEARCH:   Advanced

Blood, 1 February 2006, Vol. 107, No. 3, pp. 904-906. Prepublished online as a Blood First Edition Paper on October 6, 2005; DOI 10.1182/blood-2005-08-3449. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-08-3449v1 107/3/904    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Landgren, O. Articles by Linet, M. S. Search for Related Content PubMed PubMed Citation Articles by Landgren, O. Articles by Linet, M. S. Related Collections Immunobiology Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Brief report Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States Ola Landgren, Gloria Gridley, Ingemar Turesson, Neil E. Caporaso, Lynn R. Goldin, Dalsu Baris, Thomas R. Fears, Robert N. Hoover, and Martha S. Linet From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; and Section of Hematology, Department of Medicine, Malmö University Hospital, University of Lund, Malmö, Sweden. The age-adjusted incidence of multiple myeloma (MM) is 2-fold higher in African Americans than in whites. A few small studies have reported a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS) in African Americans versus whites. Etiologic factors for MGUS and determinants for transformation of MGUS to MM are unknown. We quantified the prevalence of MGUS and subsequent risk of MM among 4 million African American and white male veterans admitted to Veterans Affairs (VA) hospitals. The age-adjusted prevalence ratio of MGUS in African Americans compared with whites was 3.0 (2.7-3.3 95% confidence interval). Among 2046 MGUS cases, the estimated cumulative risk of MM during the first 10 years of follow-up was similar (P = .37) for African Americans (17%) and whites (15%). In the largest study to date, we suggest that the excess risk of MM in African Americans results from an increase in risk of MGUS rather than an increased risk of progression from MGUS to MM. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: O. Landgren, R. A. Kyle, R. M. Pfeiffer, J. A. Katzmann, N. E. Caporaso, R. B. Hayes, A. Dispenzieri, S. Kumar, R. J. Clark, D. Baris, et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study Blood, May 28, 2009; 113(22): 5412 - 5417. [Abstract] [Full Text] [PDF] B. M. Weiss, J. Abadie, P. Verma, R. S. Howard, and W. M. Kuehl A monoclonal gammopathy precedes multiple myeloma in most patients Blood, May 28, 2009; 113(22): 5418 - 5422. [Abstract] [Full Text] [PDF] T. M. Tancred, A. R. Belch, T. Reiman, L. M. Pilarski, and J. Kirshner Altered Expression of Fibronectin and Collagens I and IV in Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance J. Histochem. Cytochem., March 1, 2009; 57(3): 239 - 247. [Abstract] [Full Text] [PDF] M. Iwanaga, M. Tagawa, K. Tsukasaki, T. Matsuo, K.-i. Yokota, Y. Miyazaki, T. Fukushima, T. Hata, Y. Imaizumi, D. Imanishi, et al. Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors Blood, February 19, 2009; 113(8): 1639 - 1650. [Abstract] [Full Text] [PDF] H. T. Lynch, K. Ferrara, B. Barlogie, E. A. Coleman, J. F. Lynch, D. Weisenburger, W. Sanger, P. Watson, H. Nipper, V. Witt, et al. Familial Myeloma N. Engl. J. Med., July 10, 2008; 359(2): 152 - 157. [Abstract] [Full Text] [PDF] O. Landgren, L. R. Goldin, N. E. Caporaso, R. A. Kyle, and S. V. Rajkumar Genetic Predisposition for Monoclonal Gammopathy of Undetermined Significance-reply-I Mayo Clin. Proc., May 1, 2008; 83(5): 602 - 603. [Full Text] [PDF] L. M. Brown, G. Gridley, D. Check, and O. Landgren Risk of multiple myeloma and monoclonal gammopathy of undetermined significance among white and black male United States veterans with prior autoimmune, infectious, inflammatory, and allergic disorders Blood, April 1, 2008; 111(7): 3388 - 3394. [Abstract] [Full Text] [PDF] O. Landgren, J. A. Katzmann, A. W. Hsing, R. M. Pfeiffer, R. A. Kyle, E. D. Yeboah, R. B. Biritwum, Y. Tettey, A. A. Adjei, D. R. Larson, et al. Prevalence of Monoclonal Gammopathy of Undetermined Significance Among Men in Ghana Mayo Clin. Proc., December 1, 2007; 82(12): 1468 - 1473. [Abstract] [Full Text] [PDF] M. Iwanaga, M. Tagawa, K. Tsukasaki, S. Kamihira, and M. Tomonaga Prevalence of Monoclonal Gammopathy of Undetermined Significance: Study of 52,802 Persons in Nagasaki City, Japan Mayo Clin. Proc., December 1, 2007; 82(12): 1474 - 1479. [Abstract] [Full Text] [PDF] O. Landgren, I. Turesson, G. Gridley, and N. E. Caporaso Risk of Malignant Disease Among 1525 Adult Male US Veterans With Gaucher Disease Arch Intern Med, June 11, 2007; 167(11): 1189 - 1194. [Abstract] [Full Text] [PDF] L. Cook and D. H C Macdonald Management of paraproteinaemia Postgrad. Med. J., April 1, 2007; 83(978): 217 - 223. [Abstract] [Full Text] [PDF] O. Landgren, J. S. Rapkin, N. E. Caporaso, L. Mellemkjaer, G. Gridley, L. R. Goldin, and E. A. Engels Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia Blood, March 1, 2007; 109(5): 2198 - 2201. [Abstract] [Full Text] [PDF] J. Blade Monoclonal Gammopathy of Undetermined Significance N. Engl. J. Med., December 28, 2006; 355(26): 2765 - 2770. [Full Text] [PDF] O. Landgren, G. Gridley, T. R. Fears, and N. Caporaso Immune thrombocytopenic purpura does not exhibit a disparity in prevalence between African American and white veterans Blood, August 1, 2006; 108(3): 1111 - 1112. [Full Text] [PDF] H. J. Cohen, R. A. Kyle, S. V. Rajkumar, and L. J. Melton III Prevalence of monoclonal gammopathy of undetermined significance. N. Engl. J. Med., June 29, 2006; 354(26): 2832 - 2832. [Full Text] [PDF] S. V. Rajkumar, A. Dispenzieri, and R. A. Kyle Monoclonal Gammopathy of Undetermined Significance, Waldenstrom Macroglobulinemia, AL Amyloidosis, and Related Plasma Cell Disorders: Diagnosis and Treatment Mayo Clin. Proc., May 1, 2006; 81(5): 693 - 703. [Abstract] [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020