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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1255-1264. Prepublished online as a Blood First Edition Paper on October 6, 2005; DOI 10.1182/blood-2005-03-1306. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-03-1306v1 107/4/1255    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rizvi, M. A. Articles by Rosen, S. T. Search for Related Content PubMed PubMed Citation Articles by Rizvi, M. A. Articles by Rosen, S. T. Related Collections Immunobiology Neoplasia Transplantation Oncogenes and Tumor Suppressors Free Research Articles Review Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES T-cell non-Hodgkin lymphoma Mujahid A. Rizvi, Andrew M. Evens, Martin S. Tallman, Beverly P. Nelson, and Steven T. Rosen From the Division of Hematology/Oncology, Department of Medicine, and the Division of Hematopathology, Department of Pathology, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL. T-cell non-Hodgkin lymphomas (NHLs) are uncommon malignancies. The current WHO/EORTC classification recognizes 9 distinct clinicopathologic peripheral T-cell NHLs. These disorders have unique characteristics and require individualized diagnostic and therapeutic strategies. Tremendous progress has been made in recent years in the understanding of the pathogenesis of these disorders. Specific chromosomal translocations and viral infections are now known to be associated with certain lymphomas. In this review, we describe their clinical and pathologic features. We also discuss the use of molecular studies in the diagnostic work-up of T-cell lymphomas. Because of the rarity of these disorders and the lack of well-designed clinical trials, the treatment of peripheral T-cell NHLs is often challenging. Additional studies are required to learn more about the biology of these diseases, which may lead to more optimal and possibly targeted therapies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. K. Gopal, J. M. Pagel, J. R. Fromm, S. Wilbur, and O. W. Press 131I anti-CD45 radioimmunotherapy effectively targets and treats T-cell non-Hodgkin lymphoma Blood, June 4, 2009; 113(23): 5905 - 5910. [Abstract] [Full Text] [PDF] P. T. Bradford, S. S. Devesa, W. F. Anderson, and J. R. Toro Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases Blood, May 21, 2009; 113(21): 5064 - 5073. [Abstract] [Full Text] [PDF] M. Nakagawa, A. Nakagawa-Oshiro, S. Karnan, H. Tagawa, A. Utsunomiya, S. Nakamura, I. Takeuchi, K. Ohshima, and M. Seto Array Comparative Genomic Hybridization Analysis of PTCL-U Reveals a Distinct Subgroup with Genetic Alterations Similar to Lymphoma-Type Adult T-Cell Leukemia/Lymphoma Clin. Cancer Res., January 1, 2009; 15(1): 30 - 38. [Abstract] [Full Text] [PDF] S. Kako, K. Izutsu, Y. Ota, Y. Minatani, M. Sugaya, T. Momose, K. Ohtomo, Y. Kanda, S. Chiba, T. Motokura, et al. FDG-PET in T-cell and NK-cell neoplasms Ann. Onc., October 1, 2007; 18(10): 1685 - 1690. [Abstract] [Full Text] [PDF] J. P. Greer Therapy of Peripheral T/NK Neoplasms Hematology, January 1, 2006; 2006(1): 331 - 337. [Abstract] [Full Text] [PDF]

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