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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1421-1426. Prepublished online as a Blood First Edition Paper on November 3, 2005; DOI 10.1182/blood-2005-05-2112. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-05-2112v1 107/4/1421    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fuhlbrigge, R. C. Articles by Kupper, T. S. Search for Related Content PubMed PubMed Citation Articles by Fuhlbrigge, R. C. Articles by Kupper, T. S. Related Collections Immunobiology Cell Adhesion and Motility Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY CD43 is a ligand for E-selectin on CLA+ human T cells Robert C. Fuhlbrigge, Sandra L. King, Robert Sackstein, and Thomas S. Kupper From the Department of Dermatology, Brigham and Women's Hospital, Boston, MA. The recruitment of memory T cells from blood into tissues is a central element of immune surveillance and adaptive immune responses and a key feature of chronic cutaneous inflammatory diseases such as psoriasis and atopic dermatitis. Human memory T cells that infiltrate skin express the carbohydrate epitope cutaneous lymphocyte-associated antigen (CLA). Expression of the CLA epitope on T cells has been described on P-selectin glycoprotein ligand-1 (PSGL-1) and associated with the acquisition of both E-selectin and P-selectin ligand functions. In this report, we show that CD43, a sialomucin expressed constitutively on T cells, can also be decorated with the CLA epitope and serve as an E-selectin ligand. CLA expressed on CD43 was found exclusively on the high-molecular-weight (125 kDa) glycoform bearing core-2-branched O-linked glycans. CLA+ CD43 purified from human T cells supported tethering and rolling in shear flow via E-selectin but did not support binding of P-selectin. The identification and characterization of CD43 as a T-cell E-selectin ligand distinct from PSGL-1 expands the role of CD43 in the regulation of T-cell trafficking and provides new targets for the modulation of immune functions in skin. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: CD43, a novel lymphocyte ligand for E-selectin M. Ursula Norman and Paul Kubes Blood 2006 107: 1252. [Full Text] [PDF] This article has been cited by other articles: S. C. Kerr, C. B. Fieger, K. R. Snapp, and S. D. Rosen Endoglycan, a Member of the CD34 Family of Sialomucins, Is a Ligand for the Vascular Selectins J. Immunol., July 15, 2008; 181(2): 1480 - 1490. [Abstract] [Full Text] [PDF] C. Nonomura, J. Kikuchi, N. Kiyokawa, H. Ozaki, K. Mitsunaga, H. Ando, A. Kanamori, R. Kannagi, J. Fujimoto, K. Muroi, et al. CD43, but not P-Selectin Glycoprotein Ligand-1, Functions as an E-Selectin Counter-Receptor in Human Pre-B-Cell Leukemia NALL-1 Cancer Res., February 1, 2008; 68(3): 790 - 799. [Abstract] [Full Text] [PDF] M. E. Gainers, L. Descheny, S. R. Barthel, L. Liu, M.-A. Wurbel, and C. J. Dimitroff Skin-Homing Receptors on Effector Leukocytes Are Differentially Sensitive to Glyco-Metabolic Antagonism in Allergic Contact Dermatitis J. Immunol., December 15, 2007; 179(12): 8509 - 8518. [Abstract] [Full Text] [PDF] E. Galkina and K. Ley Vascular Adhesion Molecules in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., November 1, 2007; 27(11): 2292 - 2301. [Abstract] [Full Text] [PDF] P. D. Mody, J. L. Cannon, H. S. Bandukwala, K. M. Blaine, A. B. Schilling, K. Swier, and A. I. Sperling Signaling through CD43 regulates CD4 T-cell trafficking Blood, October 15, 2007; 110(8): 2974 - 2982. [Abstract] [Full Text] [PDF] M. Matsumoto, A. Shigeta, Y. Furukawa, T. Tanaka, M. Miyasaka, and T. Hirata CD43 Collaborates with P-Selectin Glycoprotein Ligand-1 to Mediate E-Selectin-Dependent T Cell Migration into Inflamed Skin J. Immunol., February 15, 2007; 178(4): 2499 - 2506. [Abstract] [Full Text] [PDF] C. Abbal, M. Lambelet, D. Bertaggia, C. Gerbex, M. Martinez, A. Arcaro, M. Schapira, and O. Spertini Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions Blood, November 15, 2006; 108(10): 3352 - 3359. [Abstract] [Full Text] [PDF] D. A. Carlow and H. J. Ziltener CD43 Deficiency Has No Impact in Competitive In Vivo Assays of Neutrophil or Activated T Cell Recruitment Efficiency J. Immunol., November 1, 2006; 177(9): 6450 - 6459. [Abstract] [Full Text] [PDF] Z. Ni, J. J. Campbell, G. Niehans, and B. Walcheck The Monoclonal Antibody CHO-131 Identifies a Subset of Cutaneous Lymphocyte-Associated Antigen T Cells Enriched in P-Selectin-Binding Cells J. Immunol., October 1, 2006; 177(7): 4742 - 4748. [Abstract] [Full Text] [PDF]

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