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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1497-1504. Prepublished online as a Blood First Edition Paper on October 20, 2005; DOI 10.1182/blood-2005-07-2951. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-07-2951v1 107/4/1497    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Barchet, W. Articles by Kemper, C. Search for Related Content PubMed PubMed Citation Articles by Barchet, W. Articles by Kemper, C. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation Winfried Barchet, Jeffrey D. Price, Marina Cella, Marco Colonna, Sandra K. MacMillan, J. Perren Cobb, Paul A. Thompson, Kenneth M. Murphy, John P. Atkinson, and Claudia Kemper From the Department of Pathology and Immunology, the Graduate Program in Immunology, the Department of Surgery, the Division of Biostatistics, and the Division of Rheumatology, Washington University School of Medicine, St Louis, MO. Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not suppress the activation/maturation of dendritic cells (DCs). DC maturation by complement/CD46-induced Tregs is mediated through simultaneous secretion of GM-CSF and soluble CD40L, factors favoring DC differentiation and reversing inhibitory effects of IL-10. Thus, CD46-induced Tregs produce a distinct cytokine profile that inhibits T-cell responses but leaves DC activation unimpaired. Such "DC-sparing" Tregs could be desirable at host/environment interfaces such as the gastrointestinal tract where their specific cytokine profile provides a mechanism that ensures unresponsiveness to commensal bacteria while maintaining reactivity to invading pathogens. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Ghannam, M. Pernollet, J.-L. Fauquert, N. Monnier, D. Ponard, M.-B. Villiers, J. Peguet-Navarro, A. Tridon, J. Lunardi, D. Gerlier, et al. Human C3 Deficiency Associated with Impairments in Dendritic Cell Differentiation, Memory B Cells, and Regulatory T Cells J. Immunol., October 1, 2008; 181(7): 5158 - 5166. [Abstract] [Full Text] [PDF] S. K. Alford, G. D. Longmore, W. F. Stenson, and C. Kemper CD46-Induced Immunomodulatory CD4+ T Cells Express the Adhesion Molecule and Chemokine Receptor Pattern of Intestinal T Cells J. Immunol., August 15, 2008; 181(4): 2544 - 2555. [Abstract] [Full Text] [PDF] C. Kemper, L. M. Mitchell, L. Zhang, and D. E. Hourcade The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis PNAS, July 1, 2008; 105(26): 9023 - 9028. [Abstract] [Full Text] [PDF] G. Meiffren, M. Flacher, O. Azocar, C. Rabourdin-Combe, and M. Faure Cutting Edge: Abortive Proliferation of CD46-Induced Tr1-Like Cells due to a Defective Akt/Survivin Signaling Pathway J. Immunol., October 15, 2006; 177(8): 4957 - 4961. [Abstract] [Full Text] [PDF]

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