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Blood, 1 March 2006, Vol. 107, No. 5, pp. 1747-1750. Prepublished online as a Blood First Edition Paper on September 27, 2005; DOI 10.1182/blood-2005-07-3046. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-07-3046v1 107/5/1747    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beutler, E. Articles by Waalen, J. Search for Related Content PubMed PubMed Citation Articles by Beutler, E. Articles by Waalen, J. Related Collections Perspectives Red Cells Free Research Articles Clinical Trials and Observations Related Letters in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PERSPECTIVES The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Ernest Beutler, and Jill Waalen From the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA. Abstract The diagnosis of anemia is an important aspect of the practice of hematology. The first step is to decide whether the patient is, in fact, anemic. Unless earlier blood counts are available, and they often are not, the physician must make his or her decision on the basis of the population distribution of hemoglobin values. How likely is it that the patient's hemoglobin value lies below the normal distribution; that is, "the lower limit"? 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