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Blood, 1 March 2006, Vol. 107, No. 5, pp. 1747-1750.
Prepublished online as a Blood First Edition Paper on September 27, 2005; DOI 10.1182/blood-2005-07-3046.
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The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?
Ernest Beutler, and
Jill Waalen
From the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
Abstract
The diagnosis of anemia is an important aspect of the practice of hematology. The first step is to decide whether the patient is, in fact, anemic. Unless earlier blood counts are available, and they often are not, the physician must make his or her decision on the basis of the population distribution of hemoglobin values. How likely is it that the patient's hemoglobin value lies below the normal distribution; that is, "the lower limit"?

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