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Blood, 1 March 2006, Vol. 107, No. 5, pp. 2030-2036. Prepublished online as a Blood First Edition Paper on November 29, 2005; DOI 10.1182/blood-2005-07-2696. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-07-2696v1 2005-07-2696v2 107/5/2030    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pende, D. Articles by Bottino, C. Search for Related Content PubMed PubMed Citation Articles by Pende, D. Articles by Bottino, C. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction Daniela Pende, Roberta Castriconi, Paola Romagnani, Grazia Maria Spaggiari, Stefania Marcenaro, Alessandra Dondero, Elena Lazzeri, Laura Lasagni, Stefania Martini, Paola Rivera, Andrea Capobianco, Lorenzo Moretta, Alessandro Moretta, and Cristina Bottino From the Istituto Nazionale per la Ricerca sul Cancro, Genoa; Dipartimento di Medicina Sperimentale (DIMES), University of Genoa; Istituto Giannina Gaslini, Genoa; Center for Research, Transfer and High Education De novo therapies (DENOthe), University of Florence; Centro di Eccellenza per la Ricerca Biomedica, University of Genoa; and Dipartimento di Oncologia, Biologia e Genetica (DOBIG), University of Genoa, Italy. In this study, we demonstrate the involvement of DNAM-1-triggering receptor and its ligands, poliovirus receptor (PVR) and Nectin-2, in natural killer (NK) cell-mediated lysis of dendritic cells (DCs). The surface expression of both ligands was up-regulated in DCs as compared to monocytes. It reached maximal densities after DC maturation induced by different stimuli including lipopolysaccharide (LPS), poly I:C, flagellin, and CD40L. Both immunohistochemical analysis and confocal microscopy revealed expression of DNAM-1 ligands by DCs in lymph nodes in which they were localized in the parafollicular T-cell region and surrounded the high endothelial venules. Remarkably, in cytolytic assays, DNAM-1 cooperated with NKp30 in the NK-mediated killing of both immature and mature DCs and the degree of contribution of DNAM-1 appeared to correlate with the surface densities of its specific ligands PVR and Nectin-2. 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