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Blood, 15 March 2006, Vol. 107, No. 6, pp. 2223-2233. Prepublished online as a Blood First Edition Paper on November 15, 2005; DOI 10.1182/blood-2005-08-3329. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-08-3329v1 107/6/2223    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Leong, K. G. Articles by Karsan, A. Search for Related Content PubMed PubMed Citation Articles by Leong, K. G. Articles by Karsan, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Neoplasia Oncogenes and Tumor Suppressors Signal Transduction Reviews in Translational Hematology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES Recent insights into the role of Notch signaling in tumorigenesis Kevin G. Leong, and Aly Karsan From the Department of Medical Biophysics and the Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver; and the Experimental Medicine Program and the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. Members of the Notch family of transmembrane receptors play an important role in cell fate determination. Over the past decade, a role for Notch in the pathogenesis of hematologic and solid malignancies has become apparent. Numerous cellular functions and microenvironmental cues associated with tumorigenesis are modulated by Notch signaling, including proliferation, apoptosis, adhesion, epithelial-to-mesenchymal transition, and angiogenesis. It is becoming increasingly evident that Notch signaling can be both oncogenic and tumor suppressive. This review highlights recent findings regarding the molecular and functional aspects of Notch-mediated neoplastic transformation. In addition, cellular mechanisms that potentially explain the complex role of Notch in tumorigenesis are discussed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K.-W. Hsu, R.-H. Hsieh, Y.-H. W. Lee, C.-H. Chao, K.-J. Wu, M.-J. Tseng, and T.-S. Yeh The Activated Notch1 Receptor Cooperates with {alpha}-Enolase and MBP-1 in Modulating c-myc Activity Mol. Cell. Biol., August 1, 2008; 28(15): 4829 - 4842. [Abstract] [Full Text] [PDF] D. R. Friedmann, J. J. Wilson, and R. A. Kovall RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex J. Biol. Chem., May 23, 2008; 283(21): 14781 - 14791. [Abstract] [Full Text] [PDF] K. Niessen and A. Karsan Notch Signaling in Cardiac Development Circ. Res., May 23, 2008; 102(10): 1169 - 1181. [Abstract] [Full Text] [PDF] P. Zhang, Y. Yang, P. A. Zweidler-McKay, and D. P.M. Hughes Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis Clin. Cancer Res., May 15, 2008; 14(10): 2962 - 2969. [Abstract] [Full Text] [PDF] N. Yamaguchi, T. Oyama, E. Ito, H. Satoh, S. Azuma, M. Hayashi, K. Shimizu, R. Honma, Y. Yanagisawa, A. Nishikawa, et al. NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells Cancer Res., March 15, 2008; 68(6): 1881 - 1888. [Abstract] [Full Text] [PDF] A. Karsan Notch and Integrin Affinity: A Sticky Situation Sci. Signal., January 15, 2008; 1(2): pe2 - pe2. [Abstract] [Full Text] [PDF] K. G. Leong, K. Niessen, I. Kulic, A. Raouf, C. Eaves, I. Pollet, and A. Karsan Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin J. Exp. Med., November 26, 2007; 204(12): 2935 - 2948. [Abstract] [Full Text] [PDF] M. Koyanagi, P. Bushoven, M. Iwasaki, C. Urbich, A. M. Zeiher, and S. Dimmeler Notch Signaling Contributes to the Expression of Cardiac Markers in Human Circulating Progenitor Cells Circ. Res., November 26, 2007; 101(11): 1139 - 1145. [Abstract] [Full Text] [PDF] B. J. Wouters, M. A. Jorda, K. Keeshan, I. Louwers, C. A. J. Erpelinck-Verschueren, D. Tielemans, A. W. Langerak, Y. He, Y. Yashiro-Ohtani, P. Zhang, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1 Blood, November 15, 2007; 110(10): 3706 - 3714. [Abstract] [Full Text] [PDF] C. F. O'Neill, S. Urs, C. Cinelli, A. Lincoln, R. J. Nadeau, R. Leon, J. Toher, C. Mouta-Bellum, R. E. Friesel, and L. Liaw Notch2 Signaling Induces Apoptosis and Inhibits Human MDA-MB-231 Xenograft Growth Am. J. Pathol., September 1, 2007; 171(3): 1023 - 1036. [Abstract] [Full Text] [PDF] C. L. Curry, L. L. Reed, E. Broude, T. E. Golde, L. Miele, and K. E. Foreman Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-{kappa}B signaling Mol. Cancer Ther., July 1, 2007; 6(7): 1983 - 1992. [Abstract] [Full Text] [PDF] S. M. Chan, A. P. Weng, R. Tibshirani, J. C. Aster, and P. J. Utz Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia Blood, July 1, 2007; 110(1): 278 - 286. [Abstract] [Full Text] [PDF] V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF] Y. Zhao, R. B. Katzman, L. M. Delmolino, I. Bhat, Y. Zhang, C. B. Gurumurthy, A. Germaniuk-Kurowska, H. V. Reddi, A. Solomon, M.-S. Zeng, et al. The Notch Regulator MAML1 Interacts with p53 and Functions as a Coactivator J. Biol. Chem., April 20, 2007; 282(16): 11969 - 11981. [Abstract] [Full Text] [PDF] G. Farnie, R. B. Clarke, K. Spence, N. Pinnock, K. Brennan, N. G. Anderson, and N. J. Bundred Novel Cell Culture Technique for Primary Ductal Carcinoma In Situ: Role of Notch and Epidermal Growth Factor Receptor Signaling Pathways J Natl Cancer Inst, April 18, 2007; 99(8): 616 - 627. [Abstract] [Full Text] [PDF] V. Fernandez-Majada, C. Aguilera, A. Villanueva, F. Vilardell, A. Robert-Moreno, A. Aytes, F. X. Real, G. Capella, M. W. Mayo, L. Espinosa, et al. Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer PNAS, January 2, 2007; 104(1): 276 - 281. [Abstract] [Full Text] [PDF] M. Ehebauer, P. Hayward, and A. Martinez-Arias Notch Signaling Pathway Sci. Signal., December 5, 2006; 2006(364): cm7 - cm7. [Abstract] [Full Text] [PDF] S. D. Hayward, J. Liu, and M. Fujimuro Notch and Wnt Signaling: Mimicry and Manipulation by Gamma Herpesviruses Sci. Signal., May 16, 2006; 2006(335): re4 - re4. [Abstract] [Full Text] [PDF]

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