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Blood, 15 March 2006, Vol. 107, No. 6, pp. 2223-2233. Prepublished online as a Blood First Edition Paper on November 15, 2005; DOI 10.1182/blood-2005-08-3329. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-08-3329v1 107/6/2223    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Leong, K. G. Articles by Karsan, A. Search for Related Content PubMed PubMed Citation Articles by Leong, K. G. Articles by Karsan, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Neoplasia Oncogenes and Tumor Suppressors Signal Transduction Reviews in Translational Hematology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES Recent insights into the role of Notch signaling in tumorigenesis Kevin G. Leong, and Aly Karsan From the Department of Medical Biophysics and the Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver; and the Experimental Medicine Program and the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada. Members of the Notch family of transmembrane receptors play an important role in cell fate determination. Over the past decade, a role for Notch in the pathogenesis of hematologic and solid malignancies has become apparent. Numerous cellular functions and microenvironmental cues associated with tumorigenesis are modulated by Notch signaling, including proliferation, apoptosis, adhesion, epithelial-to-mesenchymal transition, and angiogenesis. It is becoming increasingly evident that Notch signaling can be both oncogenic and tumor suppressive. This review highlights recent findings regarding the molecular and functional aspects of Notch-mediated neoplastic transformation. In addition, cellular mechanisms that potentially explain the complex role of Notch in tumorigenesis are discussed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. FU, K.-I. KATSUBE, and S. TOHDA Transition of Cleaved Notch1 and Gene Expression Changes in Myeloblastic Leukemia Cells Stimulated with Notch Ligands Anticancer Res, October 1, 2009; 29(10): 3967 - 3970. [Abstract] [Full Text] [PDF] O. Meurette, S. Stylianou, R. Rock, G. M. Collu, A. P. Gilmore, and K. Brennan Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells Cancer Res., June 15, 2009; 69(12): 5015 - 5022. [Abstract] [Full Text] [PDF] T.-S. Yeh, C.-W. Wu, K.-W. Hsu, W.-J. Liao, M.-C. Yang, A. F.-Y. Li, A.-M. Wang, M.-L. Kuo, and C.-W. Chi The Activated Notch1 Signal Pathway Is Associated with Gastric Cancer Progression through Cyclooxygenase-2 Cancer Res., June 15, 2009; 69(12): 5039 - 5048. [Abstract] [Full Text] [PDF] S. Indraccolo, S. Minuzzo, M. Masiero, I. Pusceddu, L. Persano, L. Moserle, A. Reboldi, E. Favaro, M. Mecarozzi, G. Di Mario, et al. Cross-talk between Tumor and Endothelial Cells Involving the Notch3-Dll4 Interaction Marks Escape from Tumor Dormancy Cancer Res., February 15, 2009; 69(4): 1314 - 1323. [Abstract] [Full Text] [PDF] E. Rosati, R. Sabatini, G. Rampino, A. Tabilio, M. Di Ianni, K. Fettucciari, A. Bartoli, S. Coaccioli, I. Screpanti, and P. Marconi Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells Blood, January 22, 2009; 113(4): 856 - 865. [Abstract] [Full Text] [PDF] B. Bin Hafeez, V. M. Adhami, M. Asim, I. A. Siddiqui, K. M. Bhat, W. Zhong, M. Saleem, M. Din, V. Setaluri, and H. Mukhtar Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator Clin. Cancer Res., January 15, 2009; 15(2): 452 - 459. [Abstract] [Full Text] [PDF] L. J. Anderson and R. Longnecker Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo Blood, January 1, 2009; 113(1): 108 - 116. [Abstract] [Full Text] [PDF] V. M. Campa, R. Gutierrez-Lanza, F. Cerignoli, R. Diaz-Trelles, B. Nelson, T. Tsuji, M. Barcova, W. Jiang, and M. Mercola Notch activates cell cycle reentry and progression in quiescent cardiomyocytes J. Cell Biol., October 6, 2008; 183(1): 129 - 141. [Abstract] [Full Text] [PDF] S. Urs, A. Roudabush, C. F. O'Neill, I. Pinz, I. Prudovsky, D. Kacer, Y. Tang, L. Liaw, and D. Small Soluble Forms of the Notch Ligands Delta1 and Jagged1 Promote in Vivo Tumorigenicity in NIH3T3 Fibroblasts with Distinct Phenotypes Am. J. Pathol., September 1, 2008; 173(3): 865 - 878. [Abstract] [Full Text] [PDF] K.-W. Hsu, R.-H. Hsieh, Y.-H. W. Lee, C.-H. Chao, K.-J. Wu, M.-J. Tseng, and T.-S. Yeh The Activated Notch1 Receptor Cooperates with {alpha}-Enolase and MBP-1 in Modulating c-myc Activity Mol. Cell. Biol., August 1, 2008; 28(15): 4829 - 4842. [Abstract] [Full Text] [PDF] D. R. Friedmann, J. J. Wilson, and R. A. Kovall RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex J. Biol. Chem., May 23, 2008; 283(21): 14781 - 14791. [Abstract] [Full Text] [PDF] K. Niessen and A. Karsan Notch Signaling in Cardiac Development Circ. Res., May 23, 2008; 102(10): 1169 - 1181. [Abstract] [Full Text] [PDF] P. Zhang, Y. Yang, P. A. Zweidler-McKay, and D. P.M. Hughes Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis Clin. Cancer Res., May 15, 2008; 14(10): 2962 - 2969. [Abstract] [Full Text] [PDF] N. Yamaguchi, T. Oyama, E. Ito, H. Satoh, S. Azuma, M. Hayashi, K. Shimizu, R. Honma, Y. Yanagisawa, A. Nishikawa, et al. NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells Cancer Res., March 15, 2008; 68(6): 1881 - 1888. [Abstract] [Full Text] [PDF] A. Karsan Notch and Integrin Affinity: A Sticky Situation Sci. Signal., January 15, 2008; 1(2): pe2 - pe2. [Abstract] [Full Text] [PDF] K. G. Leong, K. Niessen, I. Kulic, A. Raouf, C. Eaves, I. Pollet, and A. Karsan Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin J. Exp. Med., November 26, 2007; 204(12): 2935 - 2948. [Abstract] [Full Text] [PDF] M. Koyanagi, P. Bushoven, M. Iwasaki, C. Urbich, A. M. Zeiher, and S. Dimmeler Notch Signaling Contributes to the Expression of Cardiac Markers in Human Circulating Progenitor Cells Circ. Res., November 26, 2007; 101(11): 1139 - 1145. [Abstract] [Full Text] [PDF] B. J. Wouters, M. A. Jorda, K. Keeshan, I. Louwers, C. A. J. Erpelinck-Verschueren, D. Tielemans, A. W. Langerak, Y. He, Y. Yashiro-Ohtani, P. Zhang, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1 Blood, November 15, 2007; 110(10): 3706 - 3714. [Abstract] [Full Text] [PDF] C. F. O'Neill, S. Urs, C. Cinelli, A. Lincoln, R. J. Nadeau, R. Leon, J. Toher, C. Mouta-Bellum, R. E. Friesel, and L. Liaw Notch2 Signaling Induces Apoptosis and Inhibits Human MDA-MB-231 Xenograft Growth Am. J. Pathol., September 1, 2007; 171(3): 1023 - 1036. [Abstract] [Full Text] [PDF] C. L. Curry, L. L. Reed, E. Broude, T. E. Golde, L. Miele, and K. E. Foreman Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-{kappa}B signaling Mol. Cancer Ther., July 1, 2007; 6(7): 1983 - 1992. [Abstract] [Full Text] [PDF] S. M. Chan, A. P. Weng, R. Tibshirani, J. C. Aster, and P. J. Utz Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia Blood, July 1, 2007; 110(1): 278 - 286. [Abstract] [Full Text] [PDF] V. Bolos, J. Grego-Bessa, and J. L. de la Pompa Notch Signaling in Development and Cancer Endocr. Rev., May 1, 2007; 28(3): 339 - 363. [Abstract] [Full Text] [PDF] Y. Zhao, R. B. Katzman, L. M. Delmolino, I. Bhat, Y. Zhang, C. B. Gurumurthy, A. Germaniuk-Kurowska, H. V. Reddi, A. Solomon, M.-S. Zeng, et al. The Notch Regulator MAML1 Interacts with p53 and Functions as a Coactivator J. Biol. Chem., April 20, 2007; 282(16): 11969 - 11981. [Abstract] [Full Text] [PDF] G. Farnie, R. B. Clarke, K. Spence, N. Pinnock, K. Brennan, N. G. Anderson, and N. J. Bundred Novel Cell Culture Technique for Primary Ductal Carcinoma In Situ: Role of Notch and Epidermal Growth Factor Receptor Signaling Pathways J Natl Cancer Inst, April 18, 2007; 99(8): 616 - 627. [Abstract] [Full Text] [PDF] V. Fernandez-Majada, C. Aguilera, A. Villanueva, F. Vilardell, A. Robert-Moreno, A. Aytes, F. X. Real, G. Capella, M. W. Mayo, L. Espinosa, et al. Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer PNAS, January 2, 2007; 104(1): 276 - 281. [Abstract] [Full Text] [PDF] M. Ehebauer, P. Hayward, and A. Martinez-Arias Notch Signaling Pathway Sci. Signal., December 5, 2006; 2006(364): cm7 - cm7. [Abstract] [Full Text] [PDF] S. D. Hayward, J. Liu, and M. Fujimuro Notch and Wnt Signaling: Mimicry and Manipulation by Gamma Herpesviruses Sci. Signal., May 16, 2006; 2006(335): re4 - re4. [Abstract] [Full Text] [PDF]

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