|
|
Blood, 15 March 2006, Vol. 107, No. 6, pp. 2453-2460.
Prepublished online as a Blood First Edition Paper on November 22, 2005; DOI 10.1182/blood-2005-07-2831.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
Önder Alpdogan,
Vanessa M. Hubbard,
Odette M. Smith,
Neel Patel,
Sydney Lu,
Gabrielle L. Goldberg,
Daniel H. Gray,
Jared Feinman,
Adam A. Kochman,
Jeffrey M. Eng,
David Suh,
Stephanie J. Muriglan,
Richard L. Boyd, and
Marcel R. M. van den Brink
From the Departments of Medicine and Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY; and the Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia.
Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that mediates epithelial cell proliferation and differentiation in a variety of tissues, including the thymus. We studied the role of KGF in T-cell development with KGF-/- mice and demonstrated that thymic cellularity and the distribution of thymocyte subsets among KGF-/-, wildtype (WT), and KGF+/- mice were similar. However, KGF-/- mice are more vulnerable to sublethal irradiation (450 cGy), and a significant decrease was found in thymic cellularity after irradiation. Defective thymopoiesis and peripheral T-cell reconstitution were found in KGF-/- recipients of syngeneic or allogeneic bone marrow transplant, but using KGF-/- mice as a donor did not affect T-cell development after transplantation. Despite causing an early developmental block in the thymus, administration of KGF to young and old mice enhanced thymopoiesis. Exogenous KGF also accelerated thymic recovery after irradiation, cyclophosphamide, and dexamethasone treatment. Finally, we found that administering KGF before bone marrow transplantation (BMT) resulted in enhanced thymopoiesis and peripheral T-cell numbers in middle-aged recipients of an allogeneic BM transplant. We conclude that KGF plays a critical role in postnatal thymic regeneration and may be useful in treating immune deficiency conditions. (Blood. 2006;107:2453-2460)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. M. Kelly, S. L. Highfill, A. Panoskaltsis-Mortari, P. A. Taylor, R. L. Boyd, G. A. Hollander, and B. R. Blazar
Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation
Blood,
June 15, 2008;
111(12):
5734 - 5744.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. V. Komanduri, L. S. St. John, M. de Lima, J. McMannis, S. Rosinski, I. McNiece, S. G. Bryan, I. Kaur, S. Martin, E. D. Wieder, et al.
Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing
Blood,
December 15, 2007;
110(13):
4543 - 4551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bruinsma, P. L. van Soest, P. J. M. Leenen, B. N. Lambrecht, T. Cupedo, B. Lowenberg, J. J. Cornelissen, and E. Braakman
Keratinocyte Growth Factor Induces Expansion of Murine Peripheral CD4+Foxp3+ Regulatory T Cells and Increases Their Thymic Output
J. Immunol.,
December 1, 2007;
179(11):
7424 - 7430.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, E. Hexner, D. Frank, and S. G. Emerson
CD4+ T Cells Generated De Novo from Donor Hemopoietic Stem Cells Mediate the Evolution from Acute to Chronic Graft-versus-Host Disease
J. Immunol.,
September 1, 2007;
179(5):
3305 - 3314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Seggewiss, K. Lore, F. J. Guenaga, S. Pittaluga, J. Mattapallil, C. K. Chow, R. A. Koup, K. Camphausen, M. C. Nason, M. Meier-Schellersheim, et al.
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
Blood,
July 1, 2007;
110(1):
441 - 449.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N Blijlevens and S Sonis
Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis
Ann. Onc.,
May 1, 2007;
18(5):
817 - 826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-W. Chu and F. T. Hakim
KGF boosts thymic archiTECture
Blood,
May 1, 2007;
109(9):
3613 - 3614.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Rossi, L. T. Jeker, T. Ueno, S. Kuse, M. P. Keller, S. Zuklys, A. V. Gudkov, Y. Takahama, W. Krenger, B. R. Blazar, et al.
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
Blood,
May 1, 2007;
109(9):
3803 - 3811.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. H. D. Gray, D. Tull, T. Ueno, N. Seach, B. J. Classon, A. Chidgey, M. J. McConville, and R. L. Boyd
A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-15
J. Immunol.,
April 15, 2007;
178(8):
4956 - 4965.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Min, A. Panoskaltsis-Mortari, M. Kuro-o, G. A. Hollander, B. R. Blazar, and K. I. Weinberg
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
Blood,
March 15, 2007;
109(6):
2529 - 2537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. R. Blazar, D. J. Weisdorf, T. DeFor, A. Goldman, T. Braun, S. Silver, and J. L. M. Ferrara
Phase 1/2 randomized, placebo-control trial of palifermin to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT)
Blood,
November 1, 2006;
108(9):
3216 - 3222.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
