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 Blood, 15 March 2006, Vol. 107, No. 6, pp. 2531-2535.
Prepublished online as a Blood First Edition Paper on November 29, 2005; DOI 10.1182/blood-2005-04-1768.

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NEOPLASIA

Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion

Gian Matteo Rigolin, Chiara Fraulini, Maria Ciccone, Endri Mauro, Anna Maria Bugli, Cristiano De Angeli, Massimo Negrini, Antonio Cuneo, and Gianluigi Castoldi

From the Hematology Section, Department of Biomedical Sciences, Azienda Ospedaliero-Universitaria Arcispedale S. Anna; and the Microbiology Section, Department of Experimental and Diagnostic Medicine and Centro Interdipartimentale per la Ricerca sul Cancro; University of Ferrara, Italy.

In multiple myeloma (MM), circulating endothelial cells (CECs) represent a vascular marker of angiogenesis and may reflect tumor mass. In this report, we showed that, in 5 MM patients with 13q14 deletion, CECs carried the same chromosome aberration as the neoplastic plasma cells (11%-32% of CECs with 13q14 deletion). Most of the CECs displayed immunophenotypic features of endothelial progenitor cells as they expressed CD133, a marker gradually lost during endothelial differentiation and absent on mature endothelial cells. To the contrary, in 3 patients with monoclonal gammopathy of undetermined significance and 13q14 deletion, CECs were cytogenetically normal and had a mature immunophenotype. In MM CECs, immunoglobulin genes were clonally rearranged. These findings suggest a possible origin of CECs from a common hemangioblast precursor that can give rise to both plasma cells and endothelial cells and point to a direct contribution of MM-derived CECs to tumor vasculogenesis and possibly to the spreading and progression of the disease. (Blood. 2006;107:2531-2535)


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