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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2613-2618. Prepublished online as a Blood First Edition Paper on November 29, 2005; DOI 10.1182/blood-2005-07-2965. This Article Full Text Full Text (PDF) Supplemental Table and Figure All Versions of this Article: 2005-07-2965v1 107/7/2613    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Piqueras, B. Articles by Banchereau, J. Search for Related Content PubMed PubMed Citation Articles by Piqueras, B. Articles by Banchereau, J. Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES, CYTOKINES, AND INTERLEUKINS Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors Bernard Piqueras, John Connolly, Heidi Freitas, Anna Karolina Palucka, and Jacques Banchereau From the Baylor NIAID (National Institute of Allergy and Infectious Disease) Cooperative Center for Translational Research on Human Immunology and Biodefense, and Baylor Institute for Immunology Research, Dallas, TX. Host response to viral infection involves distinct effectors of innate and adaptive immunity, whose mobilization needs to be coordinated to ensure protection. Here we show that influenza virus triggers, in human blood dendritic-cell (DC) subsets (ie, plasmacytoid and myeloid DCs), a coordinated chemokine (CK) secretion program with 3 successive waves. The first one, occurring at early time points (2 to 4 hours), includes CKs potentially attracting effector cells such as neutrophils, cytotoxic T cells, and natural killer (NK) cells (CXCL16, CXCL1, CXCL2, and CXCL3). The second one occurs within 8 to 12 hours and includes CKs attracting effector memory T cells (CXCL8, CCL3, CCL4, CCL5, CXCL9, CXCL10, and CXCL11). The third wave, which occurs after 24 to 48 hours, when DCs have reached the lymphoid organs, includes CCL19, CCL22, and CXCL13, which attract naive T and B lymphocytes. Thus, human blood DC subsets carry a common program of CK production, which allows for a coordinated attraction of the different immune effectors in response to viral infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Michaelis, J. Geiler, D. Klassert, H. W. Doerr, and J. Cinatl Jr Infection of Human Retinal Pigment Epithelial Cells with Influenza A Viruses Invest. Ophthalmol. Vis. Sci., November 1, 2009; 50(11): 5419 - 5425. [Abstract] [Full Text] [PDF] W. Cao, L. Bover, M. Cho, X. Wen, S. Hanabuchi, M. Bao, D. B. Rosen, Y.-H. Wang, J. L. Shaw, Q. Du, et al. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction J. Exp. Med., July 6, 2009; 206(7): 1603 - 1614. [Abstract] [Full Text] [PDF] T. Matsui, J. E. Connolly, M. Michnevitz, D. Chaussabel, C.-I Yu, C. Glaser, S. Tindle, M. Pypaert, H. Freitas, B. Piqueras, et al. CD2 Distinguishes Two Subsets of Human Plasmacytoid Dendritic Cells with Distinct Phenotype and Functions J. Immunol., June 1, 2009; 182(11): 6815 - 6823. [Abstract] [Full Text] [PDF] N. C. Robson, H. Wei, T. McAlpine, N. Kirkpatrick, J. Cebon, and E. 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