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 Blood, 1 April 2006, Vol. 107, No. 7, pp. 2673-2679.
Prepublished online as a Blood First Edition Paper on November 29, 2005; DOI 10.1182/blood-2005-07-2797.

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HEMATOPOIESIS

Expression of rearranged TCR{gamma} genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment

Linnea Lora Veinotte, Chelsea Pamela Greenwood, Nastaran Mohammadi, Christine Anna Parachoniak, and Fumio Takei

From the Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC; and the Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC.

Natural killer (NK) cells are thought to develop from common lymphoid progenitors in the bone marrow. However, immature thymocytes also retain NK potential. Currently, the contribution of the thymus-dependent pathway in normal steady-state NK-cell development is unknown. Here, we show that TCR{gamma} genes are rearranged in approximately 5% of neonatal and 1% of adult mouse splenic NK cells, and similar levels are detected in NK cells from TCRbeta,{delta} double-knockout mice, excluding the possibility of T-cell contamination. NK-cell TCR{gamma} gene rearrangement is thymus dependent because this rearrangement is undetectable in nude mouse NK cells. These results change the current view of NK-cell development and show that a subset of NK cells develops from immature thymocytes that have rearranged TCR{gamma} genes.


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