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 Blood, 15 April 2006, Vol. 107, No. 8, pp. 3027-3033.
Prepublished online as a Blood First Edition Paper on December 22, 2005; DOI 10.1182/blood-2005-10-4114.

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REVIEW ARTICLES

Tumor vascular targeting therapy with viral vectors

Yanzheng Liu, and Albert Deisseroth

From the Sidney Kimmel Cancer Center, San Diego, CA.

Tumor angiogenesis is crucial for the progression and metastasis of cancer. The vasculature of tumor tissue is different from normal vasculature. Therefore, tumor vascular targeting therapy could represent an effective therapeutic strategy with which to suppress both primary tumor growth and tumor metastasis. The use of viral vectors for tumor vascular targeting therapy is a promising strategy based on the unique properties of viral vectors. In order to circumvent the potential problems of antiviral neutralizing antibodies, poor access to extravascular tumor tissue, and toxicities to normal tissue, viral vectors need to be modified to target the tumor endothelial cells. Viral vectors that could be used for tumor vascular targeting therapy include adenoviral vectors, adeno-associated viral vectors, retroviral vectors, lentiviral vectors, measles virus, and herpes simplex viral vectors. In this review, we will summarize the strategies available for targeting viral vectors for tumor vascular targeting therapy.


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