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Blood, 15 April 2006, Vol. 107, No. 8, pp. 3065-3073. Prepublished online as a Blood First Edition Paper on December 27, 2005; DOI 10.1182/blood-2005-05-2146. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-05-2146v1 107/8/3065    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lu, D.-P. Articles by Liu, K.-Y. Search for Related Content PubMed PubMed Citation Articles by Lu, D.-P. Articles by Liu, K.-Y. Related Collections Transplantation Immunotherapy Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation Dao-Pei Lu, Lujia Dong, Tong Wu, Xiao-Jun Huang, Mei-Jie Zhang, Wei Han, Huan Chen, Dai-Hong Liu, Zhi-Yong Gao, Yu-Hong Chen, Lan-Ping Xu, Yao-Chen Zhang, Han-Yun Ren, Dan Li, and Kai-Yan Liu From Peking University Institute of Hematology, People's Hospital, Beijing, China; Beijing Dao-Pei Hospital, Beijing, China; and the Division of Biostatistics, Medical College of Wisconsin, Milwaukee. The outcomes of 293 patients with leukemia undergoing HLA-identical sibling (n = 158) or related HLA-mismatched (n = 135) hematopoietic cell transplantation (HCT) performed during the same time period were compared. Patients received BUCY2 in HLA-identical sibling HCT or BUCY2 + ATG in mismatched HCT as conditioning regimens, followed by unmanipulated marrow and/or peripheral blood (PB) transplantation. All patients achieved full engraftment. The cumulative incidences of grades II to IV acute graft-versus-host disease (aGVHD) in the matched and mismatched cohorts were 32% (CI, 25%-39%) versus 40% (CI, 32%-48%, P = .13), respectively, with the relative risk (RR) = 0.64 (95% CI, 0.43-0.94), P = .02. The incidence of chronic GVHD did not differ significantly between the cohorts (P = .97). Two-year incidences of treatment-related mortality and relapse for matched versus mismatched were 14% (range, 9%-20%) versus 22% (range, 15%-29%) with P = .10 and 13% (range, 8%-19%) versus 18% (range, 10%-27%) with P = .40, respectively. Two-year adjusted leukemia-free survival (LFS) and overall survival were 71% (range, 63%-78%) versus 64% (range, 54%-73%) with P = .27 and 72% (range, 64%-79%) versus 71% (range, 62%-77%) with P = .72, respectively. Multivariate analyses showed that only advanced disease stage and a diagnosis of acute leukemia had increased risk of relapse, treatment failure, and overall mortality. In summary, HCT performed with related HLA-mismatched donors is a feasible approach with acceptable outcomes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Xiao-Jun, X. Lan-Ping, L. Kai-Yan, L. Dai-Hong, W. Yu, C. Huan, C. Yu-Hong, H. Wei, W. Jing-Zhi, C. Yao, et al. Partially Matched Related Donor Transplantation Can Achieve Outcomes Comparable with Unrelated Donor Transplantation for Patients with Hematologic Malignancies Clin. Cancer Res., July 15, 2009; 15(14): 4777 - 4783. [Abstract] [Full Text] [PDF] D.-P. Lu, T. Wu, Z.-Y. Gao, J.-B. Wang, X.-Y. Cao, Y.-L. Zhao, L. Dong, Y.-M. Yin, S.-Q. Ji, and W.-M. Da Significantly Reduce Acute Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation by Using Cord Blood as the Third Party Cells. Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 2211 - 2211. [Abstract] Y. j. Chang, X. y. Zhao, M. r. Huo, X. h. Luo, L. p. Xu, D. h. Liu, K. y. Liu, and X. J. Huang Comparison of Immune Reconstitution after Unmanipulated HLA-Mismatched/Haploidentical Blood and Marrow Transplantation and Unmanipulated HLA-Matched Sibling Transplantation in Patients with Hematological Malignancies. Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 2221 - 2221. [Abstract]

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