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Blood, 15 April 2006, Vol. 107, No. 8, pp. 3173-3180. Prepublished online as a Blood First Edition Paper on December 27, 2005; DOI 10.1182/blood-2005-10-4111. This Article Full Text Full Text (PDF) Supplemental Figures and Tables All Versions of this Article: 2005-10-4111v1 107/8/3173    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sood, R. Articles by Weiler, H. Search for Related Content PubMed PubMed Citation Articles by Sood, R. Articles by Weiler, H. Related Collections Hemostasis, Thrombosis, and Vascular Biology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Fetomaternal cross talk in the placental vascular bed: control of coagulation by trophoblast cells Rashmi Sood, Shawn Kalloway, Alan E. Mast, Cecilia J. Hillard, and Hartmut Weiler From the Blood Research Institute, Blood Center of Wisconsin; the Department of Pharmacology and Toxicology, Medical College of Wisconsin; and the Department of Physiology, Medical College of Wisconsin, Milwaukee. Humans and rodents exhibit a peculiar type of placentation in which zygote-derived trophoblast cells, rather than endothelial cells, line the terminal maternal vascular space. This peculiar aspect of the placental vasculature raises important questions about the relative contribution of fetal and maternal factors in the local control of hemostasis in the placenta and how these might determine the phenotypic expression of thrombophilia-associated complications of pregnancy. Using genomewide expression analysis, we identify a panel of genes that determine the ability of fetal trophoblast cells to regulate hemostasis at the fetomaternal interface. We show that spontaneous differentiation of trophoblast stem cells is associated with the acquisition of an endothelial cell–like thromboregulatory gene expression program. This program is developmentally regulated and conserved between mice and humans. We further show that trophoblast cells sense, via the expression of protease activated receptors, the presence of activated coagulation factors. Engagement of these receptors results in cell-type specific changes in gene expression. Our observations define candidate fetal genes that are potential risk modifiers of maternal thrombophilia-associated pregnancy complications and provide evidence that coagulation activation at the fetomaternal interface can affect trophoblast physiology altering placental function in the absence of frank thrombosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Trophoblast cells sense maternal hemostasis Jean-Christophe Gris Blood 2006 107: 3019-3020. [Full Text] [PDF] This article has been cited by other articles: S. M. Bates, I. A. Greer, I. Pabinger, S. Sofaer, and J. Hirsh Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 844S - 886S. [Abstract] [Full Text] [PDF] P. Lefevre, D. B. Campos, and B. D. Murphy Talk to Me: The Embryo Dictates Gene Expression by the Endometrium Endocrinology, September 1, 2007; 148(9): 4170 - 4172. [Full Text] [PDF] R. Sood, M. Zogg, R. J. Westrick, Y.-h. Guo, E. J. Kerschen, G. Girardi, J. E. Salmon, S. R. Coughlin, and H. Weiler Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers J. Exp. Med., May 14, 2007; 204(5): 1049 - 1056. [Abstract] [Full Text] [PDF] U. Fernekorn, E. C. Butcher, J. Behrends, C. M. Karsten, A. Robke, T. J. Schulze, H. Kirchner, and A. Kruse Selectin, Platelet Plays a Critical Role in Granulocyte Access to the Pregnant Mouse Uterus Under Physiological and Pathological Conditions Biol Reprod, April 1, 2007; 76(4): 645 - 653. [Abstract] [Full Text] [PDF] S. Nguyen Huu, M. Oster, S. Uzan, F. Chareyre, S. Aractingi, and K. Khosrotehrani Maternal neoangiogenesis during pregnancy partly derives from fetal endothelial progenitor cells PNAS, February 6, 2007; 104(6): 1871 - 1876. [Abstract] [Full Text] [PDF]

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