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Blood, 15 April 2006, Vol. 107, No. 8, pp. 3258-3264. Prepublished online as a Blood First Edition Paper on December 22, 2005; DOI 10.1182/blood-2005-11-4374. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-11-4374v1 107/8/3258    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Belyakov, I. M. Articles by Berzofsky, J. A. Search for Related Content PubMed PubMed Citation Articles by Belyakov, I. M. Articles by Berzofsky, J. A. Related Collections Immunobiology Immunotherapy Free Research Articles Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Impact of vaccine-induced mucosal high-avidity CD8+CTLs in delay of AIDS viral dissemination from mucosa Igor M. Belyakov, Vladimir A. Kuznetsov, Brian Kelsall, Dennis Klinman, Marcin Moniuszko, Michael Lemon, Phillip D. Markham, Ranajit Pal, John D. Clements, Mark G. Lewis, Warren Strober, Genoveffa Franchini, and Jay A. Berzofsky From the Vaccine Branch, National Cancer Institute (NCI) and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH), Bethesda, MD; Division of Information and Mathematical Sciences, Genome Institute of Singapore, Singapore; Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD; Advanced BioScience Laboratories, Kensington, MD; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA; and Southern Research Institute, Frederick, MD. Natural HIV transmission occurs through mucosa, but it is debated whether mucosal cytotoxic T lymphocytes (CTLs) can prevent or reduce dissemination from the initial mucosal site to the systemic circulation. Also, the role of CTL avidity in mucosal AIDS viral transmission is unknown. To address these questions, we used delay in acute-phase peak viremia after intrarectal challenge as an indicator of systemic dissemination. We found that a peptide-prime/poxviral boost vaccine inducing high levels of high-avidity mucosal CTLs can have an impact on dissemination of intrarectally administered pathogenic SHIV-ku2 in macaques and that such protection correlates better with mucosal than with systemic CTLs and particularly with levels of high-avidity mucosal CTLs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Keeping the barbarian at the gate George K. Lewis Blood 2006 107: 3020. [Full Text] [PDF] This article has been cited by other articles: I. M. Belyakov, S. Kozlowski, M. Mage, J. D. Ahlers, L. F. Boyd, D. H. Margulies, and J. A. Berzofsky Role of {alpha}3 domain of class I MHC molecules in the activation of high- and low-avidity CD8+ CTLs Int. Immunol., December 1, 2007; 19(12): 1413 - 1420. [Abstract] [Full Text] [PDF] I. M. Belyakov, D. Isakov, Q. Zhu, A. Dzutsev, and J. A. Berzofsky A Novel Functional CTL Avidity/Activity Compartmentalization to the Site of Mucosal Immunization Contributes to Protection of Macaques against Simian/Human Immunodeficiency Viral Depletion of Mucosal CD4+ T Cells J. Immunol., June 1, 2007; 178(11): 7211 - 7221. [Abstract] [Full Text] [PDF] M. C. G. Marcondes, T. H. Burdo, S. Sopper, S. Huitron-Resendiz, C. Lanigan, D. Watry, C. Flynn, M. Zandonatti, and H. S. Fox Enrichment and Persistence of Virus-Specific CTL in the Brain of Simian Immunodeficiency Virus-Infected Monkeys Is Associated with a Unique Cytokine Environment J. Immunol., May 1, 2007; 178(9): 5812 - 5819. [Abstract] [Full Text] [PDF] A. H. Dzutsev, I. M. Belyakov, D. V. Isakov, D. H. Margulies, and J. A. Berzofsky Avidity of CD8 T cells sharpens immunodominance Int. Immunol., April 1, 2007; 19(4): 497 - 507. [Abstract] [Full Text] [PDF] I. M. Belyakov, D. Isakov, Q. Zhu, A. Dzutsev, D. Klinman, and J. A. Berzofsky Enhancement of CD8+ T Cell Immunity in the Lung by CpG Oligodeoxynucleotides Increases Protective Efficacy of a Modified Vaccinia Ankara Vaccine against Lethal Poxvirus Infection Even in a CD4-Deficient Host J. Immunol., November 1, 2006; 177(9): 6336 - 6343. [Abstract] [Full Text] [PDF]

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