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 Blood, 15 April 2006, Vol. 107, No. 8, pp. 3265-3270.
Prepublished online as a Blood First Edition Paper on December 27, 2005; DOI 10.1182/blood-2005-06-2480.

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IMMUNOBIOLOGY

Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs

Silke Appel, Anita Bringmann, Frank Grünebach, Markus M. Weck, Jürgen Bauer, and Peter Brossart

From the Department of Hematology, Oncology and Immunology and the Department of Dermatology, University of Tübingen, Germany; and the Department of Biomedicine, University of Bergen, Norway.

Dendritic cells (DCs) are recognized as the most potent antigen-presenting cells of the immune system with the unique ability to initiate and maintain primary immune responses. In order to better characterize the functional and phenotypic features of DCs, a subtractive cDNA library to identify differentially expressed genes in monocyte-derived DCs (MDCs) was constructed. Using this approach, we found that the epithelial transcription factor ESE-3, which was previously shown to be exclusively expressed in cells of epithelial origin, is differentially expressed in MDCs. This was further confirmed by reverse transcriptase–polymerase chain reaction (RT-PCR) and Western blot analyses. The expression of ESE-3 is up-regulated upon maturation of MDCs and inhibited by treating the cells with IL-10 or IFN-{gamma}. Knockdown experiments using siRNA suggest that ESE-3 plays an important role during MDC development. Our results might help to improve the phenotypic characterization of DCs and lead to a better understanding of the cellular mechanisms involved in antigen presentation and T-cell stimulation.


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