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Blood, 1 May 2006, Vol. 107, No. 9, pp. 3463-3468. Prepublished online as a Blood First Edition Paper on December 29, 2005; DOI 10.1182/blood-2005-09-3640. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-09-3640v1 107/9/3463    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cairoli, R. Articles by Morra, E. Search for Related Content PubMed PubMed Citation Articles by Cairoli, R. Articles by Morra, E. Related Collections Neoplasia Oncogenes and Tumor Suppressors Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study Roberto Cairoli, Alessandro Beghini, Giovanni Grillo, Gianpaolo Nadali, Francesca Elice, Carla Barbara Ripamonti, Patrizia Colapietro, Michele Nichelatti, Laura Pezzetti, Monia Lunghi, Antonio Cuneo, Assunta Viola, Felicetto Ferrara, Mario Lazzarino, Francesco Rodeghiero, Giovanni Pizzolo, Lidia Larizza, and Enrica Morra From the Division of Hematology, Niguarda Hospital, Milan, Italy; Department of Biology and Genetics for Medical Sciences, School of Medicine, University of Milan, Italy; Department of Clinical and Experimental Medicine, University of Verona, Italy; Department of Hematology, S Bortolo Hospital, Vicenza Italy; Division of Hematology, IRCCS Policlinico San Matteo, University of Pavia, Italy; Department of Hematology, S Anna Hospital, Ferrara, Italy; and Division of Hematology and Stem Cell Transplantation Unit, Cardarelli General Hospital, Naples, Italy. Distinct forms of tyrosine kinase domain (TKD), juxtamembrane domain, exon 8, and internal tandem duplication (ITD) mutations of c-KIT, were observed in about 46% of core binding factor leukemia (CBFL) patients. To evaluate their prognostic significance, 67 adult patients with CBFL were analyzed to ascertain the c-KIT mutation status. In acute myeloid leukemia (AML) with t(8;21), the presence of c-KIT TKD mutation at codon 816 (TKD816) was associated with a high white blood cell count at diagnosis (median, 29.60 x 109/L) and a higher incidence (33%) of extramedullary leukemia (EML) during the course of the disease. Data also showed that the TKD816 mutated patients (n = 12) had a significantly higher incidence of relapse and a lower overall survival (OS) at 24 months, compared with the 17 c-KIT unmutated (c-KIT–) patients (90% vs 35.3%, P = .002; 25% vs 76.5%, P = .006, respectively). No difference in relapse incidence (P = .126) and OS (P = .474) was observed between the c-KIT mutated other than TKD816 (n = 7) and the c-KIT– patients. These findings indicate that c-KIT TKD816 mutation has a negative impact on the outcome of AML with t(8;21). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Faderl, A. Pal, W. Bornmann, M. Albitar, D. Maxwell, Q. Van, Z. Peng, D. Harris, Z. Liu, I. Hazan-Halevy, et al. Kit Inhibitor APcK110 Induces Apoptosis and Inhibits Proliferation of Acute Myeloid Leukemia Cells Cancer Res., May 1, 2009; 69(9): 3910 - 3917. [Abstract] [Full Text] [PDF] A. M. Vannucchi, P. Guglielmelli, and A. Tefferi Advances in Understanding and Management of Myeloproliferative Neoplasms CA Cancer J Clin, May 1, 2009; 59(3): 171 - 191. [Abstract] [Full Text] [PDF] E. Iwanaga, T. Nanri, N. Matsuno, T. Kawakita, H. Mitsuya, and N. 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