|
|
Blood, 1 May 2006, Vol. 107, No. 9, pp. 3656-3664.
Prepublished online as a Blood First Edition Paper on January 12, 2006; DOI 10.1182/blood-2005-10-4190.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response
Shigeharu Fujita,
Ken-ichiro Seino,
Kaori Sato,
Yumiko Sato,
Kawori Eizumi,
Naohide Yamashita,
Masaru Taniguchi, and
Katsuaki Sato
From the Laboratory for Dendritic Cell Immunobiology and the Laboratory for Immune Regulation, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan; the Department of Advanced Medical Science, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Bacterial infection triggers host inflammation through the activation of immune cells, leading to the elimination of bacteria. However, the regulatory mechanisms of the host inflammatory response remain unknown. Here we report that a subset of potent tolerogenic dendritic cells (DCs), regulatory DCs (DCregs), control the systemic inflammatory response. Unlike normal DCs, which produced proinflammatory cytokines in response to bacterial lipopolysaccharide (LPS), DCregs produced fewer proinflammatory cytokines and instead preferentially produced interleukin-10 (IL-10), and these events involved the expression of I BNS and Bcl-3 as well as cyclic AMP (cAMP)-mediated activation of protein kinase A (PKA). In addition, DCregs not only suppressed LPS-induced production of proinflammatory cytokines in macrophages, but also reduced their serum levels in mice. Furthermore, DCregs protected mice against the lethality induced by experimental endotoxemia and bacterial peritonitis. The inhibitory effect of DCregs against inflammatory responses involved the production of IL-10. On the other hand, naturally existing tolerogenic DC subsets producing IL-10, CD11clowCD45RBhigh DCs, also suppressed LPS-induced host inflammatory responses. Thus, a subset of tolerogenic DCs act as potential regulators of the host inflammatory response, and they might have preventive and therapeutic potential for the treatment of systemic as well as local inflammatory diseases.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
Dendritic cells get VIP treatment
- Edmund K. Waller
Blood 2006 107: 3423-3424.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
K. Sato, K. Eizumi, T. Fukaya, S. Fujita, Y. Sato, H. Takagi, M. Yamamoto, N. Yamashita, A. Hijikata, H. Kitamura, et al.
Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease
Blood,
May 7, 2009;
113(19):
4780 - 4789.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C Ward, K Eger, J Diboll, D Jones, M A Haniffa, M Brodlie, A Fisher, J L Lordan, P A Corris, and C M U Hilkens
Bronchial epithelial cells cultured from clinically stable lung allograft patients promote the development of macrophages from monocytes rather than dendritic cells
Thorax,
May 1, 2009;
64(5):
430 - 435.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Usui, M. Takeuchi, T. Hattori, Y. Okunuki, K. Nagasawa, T. Kezuka, K. Okumura, H. Yagita, H. Akiba, and H. Goto
Suppression of Experimental Autoimmune Uveoretinitis by Regulatory Dendritic Cells in Mice
Arch Ophthalmol,
April 1, 2009;
127(4):
514 - 519.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Kim and P. J. Nelson
Interfacing Kidney Stroma with Dendritic Cells
J. Am. Soc. Nephrol.,
April 1, 2009;
20(4):
685 - 686.
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. D. Jung, M.-G. Lee, J. H. Chang, J. S. Lee, Y.-I. Jeong, C.-M. Lee, W. S. Park, J. Han, S.-K. Seo, S. Y. Lee, et al.
Blockade of Indoleamine 2,3-Dioxygenase Protects Mice against Lipopolysaccharide-Induced Endotoxin Shock
J. Immunol.,
March 1, 2009;
182(5):
3146 - 3154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. L. Gautier, T. Huby, F. Saint-Charles, B. Ouzilleau, M. J. Chapman, and P. Lesnik
Enhanced Dendritic Cell Survival Attenuates Lipopolysaccharide-Induced Immunosuppression and Increases Resistance to Lethal Endotoxic Shock
J. Immunol.,
May 15, 2008;
180(10):
6941 - 6946.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. N. Couper, D. G. Blount, and E. M. Riley
IL-10: The Master Regulator of Immunity to Infection
J. Immunol.,
May 1, 2008;
180(9):
5771 - 5777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Wong and A. Rodriguez
Plasmodium Infection and Endotoxic Shock Induce the Expansion of Regulatory Dendritic Cells
J. Immunol.,
January 15, 2008;
180(2):
716 - 726.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Abe, K. P. Nguyen, S. D. Fine, J.-H. Mo, C. Shen, S. Shenouda, M. Corr, S. Jung, J. Lee, L. Eckmann, et al.
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
PNAS,
October 23, 2007;
104(43):
17022 - 17027.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Hubert, N. Jacobs, J.-H. Caberg, J. Boniver, and P. Delvenne
The cross-talk between dendritic and regulatory T cells: good or evil?
J. Leukoc. Biol.,
October 1, 2007;
82(4):
781 - 794.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Xin, Y. Li, and L. Soong
Role of Interleukin-1{beta} in Activating the CD11chigh CD45RB Dendritic Cell Subset and Priming Leishmania amazonensis- Specific CD4+ T Cells In Vitro and In Vivo
Infect. Immun.,
October 1, 2007;
75(10):
5018 - 5026.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. D. Iliev, G. Matteoli, and M. Rescigno
The yin and yang of intestinal epithelial cells in controlling dendritic cell function
J. Exp. Med.,
October 1, 2007;
204(10):
2253 - 2257.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Y. Lan, Z. Wang, G. Raimondi, W. Wu, B. L. Colvin, A. De Creus, and A. W. Thomson
"Alternatively Activated" Dendritic Cells Preferentially Secrete IL-10, Expand Foxp3+CD4+ T Cells, and Induce Long-Term Organ Allograft Survival in Combination with CTLA4-Ig
J. Immunol.,
November 1, 2006;
177(9):
5868 - 5877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
