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Blood, 1 July 2006, Vol. 108, No. 1, pp. 200-202. Prepublished online as a Blood First Edition Paper on March 2, 2006; DOI 10.1182/blood-2005-12-4884. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-12-4884v1 108/1/200    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hao, Z. Articles by O'Rourke, J. Search for Related Content PubMed PubMed Citation Articles by Hao, Z. Articles by O'Rourke, J. Related Collections Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report New transgenic evidence for a system of sympathetic axons able to express tissue plasminogen activator (t-PA) within arterial/arteriolar walls Zhifang Hao, Caiying Guo, Xi Jiang, Susan Krueger, Thomas Pietri, Sylvie Dufour, Robert E. Cone, and James O'Rourke Department of Immunology, University of Connecticut Health Center, Farmington; and the Institut Curie, Paris, France. Sympathetic axons embedded in a few arterioles and vasa vasora were recently shown to store tissue plasminogen activator (t-PA) in vesicles. But the extension of such t-PA axons to arteries and arterioles throughout the organism has not been verified. Confirmation of this anatomy would identify a second significant source of vessel wall t-PA. To visualize fine embedded axons independent of endothelium, we created a transgenic mouse whose expressions of the t-PA promoter and enhanced green fluorescent protein are confined to sympathetic neurons and other neural crest derivatives. Confocal images reveal the extension of t-PA axons to arterioles serving heart, brain, kidney, lung, mesentery, and skin; plus aortic, carotid, and mesenteric artery walls. Ganglion neurons and adrenal chromaffin cells also show strong expressions. These new sightings confirm the existence of a system of t-PA axons that is prominent in arterioles, and compatible with the release of neural t-PA into their walls. (Blood. 2006;108:200-202) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: U. Schaefer, S. Vorlova, T. Machida, J. P. Melchor, S. Strickland, and R. Levi Modulation of Sympathetic Activity by Tissue Plasminogen Activator Is Independent of Plasminogen and Urokinase J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 265 - 273. [Abstract] [Full Text] [PDF] J. O'Rourke, Z. Hao, C. Guo, and R. E. Cone Distribution of the Tissue Plasminogen Activator (t-PA) Promotor to Perivascular Sympathetic Nerves and Other Neural Crest Derivatives: Evidence of a Dispersed Plasmin Proteolysis FASEB J, April 1, 2007; 21(5): A194 - A194. L. A. Miles, N. M. Andronicos, N. Baik, and R. J. Parmer Cell-Surface Actin Binds Plasminogen and Modulates Neurotransmitter Release from Catecholaminergic Cells J. Neurosci., December 13, 2006; 26(50): 13017 - 13024. [Abstract] [Full Text] [PDF]

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