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Blood, 1 July 2006, Vol. 108, No. 1, pp. 209-217. Prepublished online as a Blood First Edition Paper on March 7, 2006; DOI 10.1182/blood-2005-12-4897. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-12-4897v1 108/1/209    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dunham, R. Articles by Silvestri, G. Search for Related Content PubMed PubMed Citation Articles by Dunham, R. Articles by Silvestri, G. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus Richard Dunham, Paola Pagliardini, Shari Gordon, Beth Sumpter, Jessica Engram, Abeer Moanna, Mirko Paiardini, Judith N. Mandl, Benton Lawson, Seema Garg, Harold M. McClure, Yong-Xian Xu, Chris Ibegbu, Kirk Easley, Nathalia Katz, Ivona Pandrea, Cristian Apetrei, Donald L. Sodora, Silvija I. Staprans, Mark B. Feinberg, and Guido Silvestri From Emory University, Emory Vaccine Center, Yerkes Primate Research Center, and the School of Public Health, Atlanta, GA; Tulane University, Tulane National Primate Research Center and Tulane Health Sciences Center, New Orleans, LA; the University of Texas Southwestern, Department of Medicine, Dallas, TX; Merck, Vaccine Division, West Point, PA; and the University of Pennsylvania, Department of Pathology and Laboratory Medicine, Philadelphia, PA. In contrast to human immunodeficiency virus (HIV)-infected humans, natural hosts for simian immunodeficiency virus (SIV) very rarely progress to acquired immunodeficiency syndrome (AIDS). While the mechanisms underlying this disease resistance are still poorly understood, a consistent feature of natural SIV infection is the absence of the generalized immune activation associated with HIV infection. To investigate the immunologic mechanisms underlying the absence of AIDS in SIV-infected sooty mangabeys (SMs), a natural host species, we performed a detailed analysis of the SIV-specific cellular immune responses in 110 SIV-infected SMs. We found that while SIV-specific T-cell responses are detectable in the majority of animals, their magnitude and breadth are, in fact, lower than what has been described in HIV-infected humans, both in terms of cytokine production (ie, IFN-, TNF-, and IL-2) and degranulation (ie, CD107a expression). Of importance, SIV-specific T-cell responses were similarly low when either SIVmac239-derived peptides or autologous SIVsmm peptides were used as stimuli. No correlation was found between SIV-specific T-cell responses and either viral load or CD4+ T-cell count, or between these responses and markers of T-cell activation and proliferation. These findings indicate that the absence of AIDS in naturally SIV-infected sooty mangabeys is independent of a strong cellular immune response to the virus. (Blood. 2006;108:209-217) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. D. Estes, S. N. Gordon, M. Zeng, A. M. Chahroudi, R. M. Dunham, S. I. Staprans, C. S. Reilly, G. Silvestri, and A. T. Haase Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques J. Immunol., May 15, 2008; 180(10): 6798 - 6807. [Abstract] [Full Text] [PDF] I. Pandrea, R. M. Ribeiro, R. Gautam, T. Gaufin, M. Pattison, M. Barnes, C. Monjure, C. Stoulig, J. Dufour, W. Cyprian, et al. Simian Immunodeficiency Virus SIVagm Dynamics in African Green Monkeys J. Virol., April 1, 2008; 82(7): 3713 - 3724. [Abstract] [Full Text] [PDF] S. N. Gordon, R. M. Dunham, J. C. Engram, J. Estes, Z. Wang, N. R. Klatt, M. Paiardini, I. V. Pandrea, C. Apetrei, D. L. Sodora, et al. Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis J. Virol., April 1, 2008; 82(7): 3725 - 3735. [Abstract] [Full Text] [PDF] M.-C. Cumont, O. Diop, B. Vaslin, C. Elbim, L. Viollet, V. Monceaux, S. Lay, G. Silvestri, R. Le Grand, M. Muller-Trutwin, et al. Early Divergence in Lymphoid Tissue Apoptosis between Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infections of Nonhuman Primates J. Virol., February 1, 2008; 82(3): 1175 - 1184. [Abstract] [Full Text] [PDF] D. A. Kosub, G. Lehrman, J. M. Milush, D. Zhou, E. Chacko, A. Leone, S. Gordon, G. Silvestri, J. G. Else, P. Keiser, et al. Gamma/Delta T-Cell Functional Responses Differ after Pathogenic Human Immunodeficiency Virus and Nonpathogenic Simian Immunodeficiency Virus Infections J. Virol., February 1, 2008; 82(3): 1155 - 1165. [Abstract] [Full Text] [PDF] S. N. Gordon, N. R. Klatt, S. E. Bosinger, J. M. Brenchley, J. M. Milush, J. C. Engram, R. M. Dunham, M. Paiardini, S. Klucking, A. Danesh, et al. Severe Depletion of Mucosal CD4+ T Cells in AIDS-Free Simian Immunodeficiency Virus-Infected Sooty Mangabeys J. Immunol., September 1, 2007; 179(5): 3026 - 3034. [Abstract] [Full Text] [PDF] J. M. Milush, J. D. Reeves, S. N. Gordon, D. Zhou, A. Muthukumar, D. A. Kosub, E. Chacko, L. D. Giavedoni, C. C. Ibegbu, K. S. Cole, et al. Virally Induced CD4+ T Cell Depletion Is Not Sufficient to Induce AIDS in a Natural Host J. Immunol., September 1, 2007; 179(5): 3047 - 3056. [Abstract] [Full Text] [PDF] A. P. Barry, G. Silvestri, J. T. Safrit, B. Sumpter, N. Kozyr, H. M. McClure, S. I. Staprans, and M. B. 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Correlates of Preserved CD4+ T Cell Homeostasis during Natural, Nonpathogenic Simian Immunodeficiency Virus Infection of Sooty Mangabeys: Implications for AIDS Pathogenesis J. Immunol., February 1, 2007; 178(3): 1680 - 1691. [Abstract] [Full Text] [PDF] G. Brennan, M. D. Podell, R. Wack, S. Kraft, J. L. Troyer, H. Bielefeldt-Ohmann, and S. VandeWoude Neurologic Disease in Captive Lions (Panthera leo) with Low-Titer Lion Lentivirus Infection J. Clin. Microbiol., December 1, 2006; 44(12): 4345 - 4352. [Abstract] [Full Text] [PDF] S. VandeWoude and C. Apetrei Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses Clin. Microbiol. Rev., October 1, 2006; 19(4): 728 - 762. [Abstract] [Full Text] [PDF]

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