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Blood, 1 July 2006, Vol. 108, No. 1, pp. 270-277. Prepublished online as a Blood First Edition Paper on March 9, 2006; DOI 10.1182/blood-2006-01-0017. This Article Full Text Full Text (PDF) All Versions of this Article: 2006-01-0017v1 108/1/270    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Martin, B. Articles by Lucas, B. Search for Related Content PubMed PubMed Citation Articles by Martin, B. Articles by Lucas, B. Related Collections Immunobiology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment Bruno Martin, Chantal Bécourt, Boris Bienvenu, and Bruno Lucas From the Institut National de la Santé et de la Recherche Médicale (INSERM) U561, Saint-Vincent-de-Paul Hospital, Paris, France; and the Department of Immunology, Cochin Institute, INSERM U567, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8104, René Descartes University, Cochin Hospital, Paris, France. The role of self-recognition in the maintenance of the peripheral CD4+ T-cell pool has been extensively studied, but no clear answer has so far emerged. Indeed, in studies of the role of self-major histocompatibility complex (MHC) molecules in CD4+ T-cell survival, several parameters must be taken into account when interpreting the results: (1) in a lymphopenic environment, observations are biased by concomitant proliferation of T cells arising in MHC-expressing mice; (2) the peripheral T-cell compartment is qualitatively and quantitatively different in nonlymphopenic, normal, and MHC class II-deficient mice; and (3) in C57BL/6 A-/- mice (traditionally considered MHC class II-deficient), the A chain and the E chain associate to form a hybrid AE MHC class II molecule. In light of these considerations, we revisited the role of interactions with MHC class II molecules in the survival of peripheral CD4+ T cells. We found that the answer to the question "is self-recognition required for CD4+ T cells to survive?" is not a simple yes or no. Indeed, although long-term survival of CD4+ T cells does not depend on self-recognition in lymphopenic mice, interactions with MHC class II molecules are required for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. (Blood. 2006;108:270-277) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: When TCR tickling helps T cells survive Benedict Seddon Blood 2006 108: 5. [Full Text] [PDF] This article has been cited by other articles: H. Tsukamoto, K. Clise-Dwyer, G. E. Huston, D. K. Duso, A. L. Buck, L. L. Johnson, L. Haynes, and S. L. Swain Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects PNAS, October 27, 2009; 106(43): 18333 - 18338. [Abstract] [Full Text] [PDF] M.-C. Gagnerault, O. Lanvin, V. Pasquier, C. Garcia, D. Damotte, B. Lucas, and F. 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Th2 Lymphoproliferative Disorder of LatY136F Mutant Mice Unfolds Independently of TCR-MHC Engagement and Is Insensitive to the Action of Foxp3+ Regulatory T Cells J. Immunol., February 1, 2008; 180(3): 1565 - 1575. [Abstract] [Full Text] [PDF] A. De Riva, C. Bourgeois, G. Kassiotis, and B. Stockinger Noncognate Interaction with MHC Class II Molecules Is Essential for Maintenance of T Cell Metabolism to Establish Optimal Memory CD4 T Cell Function J. Immunol., May 1, 2007; 178(9): 5488 - 5495. [Abstract] [Full Text] [PDF]

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