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Blood, 1 July 2006, Vol. 108, No. 1, pp. 270-277.
Prepublished online as a Blood First Edition Paper on March 9, 2006; DOI 10.1182/blood-2006-01-0017.
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IMMUNOBIOLOGY
Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment
Bruno Martin,
Chantal Bécourt,
Boris Bienvenu, and
Bruno Lucas
From the Institut National de la Santé et de la Recherche Médicale (INSERM) U561, Saint-Vincent-de-Paul Hospital, Paris, France; and the Department of Immunology, Cochin Institute, INSERM U567, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 8104, René Descartes University, Cochin Hospital, Paris, France.
The role of self-recognition in the maintenance of the peripheral CD4+ T-cell pool has been extensively studied, but no clear answer has so far emerged. Indeed, in studies of the role of self-major histocompatibility complex (MHC) molecules in CD4+ T-cell survival, several parameters must be taken into account when interpreting the results: (1) in a lymphopenic environment, observations are biased by concomitant proliferation of T cells arising in MHC-expressing mice; (2) the peripheral T-cell compartment is qualitatively and quantitatively different in nonlymphopenic, normal, and MHC class II-deficient mice; and (3) in C57BL/6 A -/- mice (traditionally considered MHC class II-deficient), the A chain and the E chain associate to form a hybrid AE MHC class II molecule. In light of these considerations, we revisited the role of interactions with MHC class II molecules in the survival of peripheral CD4+ T cells. We found that the answer to the question "is self-recognition required for CD4+ T cells to survive?" is not a simple yes or no. Indeed, although long-term survival of CD4+ T cells does not depend on self-recognition in lymphopenic mice, interactions with MHC class II molecules are required for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. (Blood. 2006;108:270-277)
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