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Blood, 1 July 2006, Vol. 108, No. 1, pp. 292-296. Prepublished online as a Blood First Edition Paper on March 9, 2006; DOI 10.1182/blood-2005-11-4620. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-11-4620v1 108/1/292    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Landgren, O. Articles by Goldin, L. R. Search for Related Content PubMed PubMed Citation Articles by Landgren, O. Articles by Goldin, L. R. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries Ola Landgren, Eric A. Engels, Neil E. Caporaso, Gloria Gridley, Lene Mellemkjaer, Kari Hemminki, Martha S. Linet, and Lynn R. Goldin From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; the Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark; the Department of Biosciences at Novum, Karolinska Institute, Stockholm, Sweden; and the Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany. A population-based case-control study was conducted to evaluate risk of developing chronic lymphocytic leukemia (CLL) associated with personal and/or family history of autoimmune and related diseases. Data were obtained for all (n = 7764) patients diagnosed with CLL in Sweden and Denmark over a 40-year period and with linkable relatives, 16 658 matched control subjects, and first-degree relatives of patients (n = 17 991) and control subjects (n = 39 388). Odds ratios (ORs) were calculated to quantify risk of CLL in relation to personal/family history of 32 autoimmune and related disorders. The risk of CLL was significantly increased among subjects with a personal history of pernicious anemia (OR = 1.94; 1.18-3.18), mainly in the 0- to 1-year latency period. A significantly decreased risk of CLL was found among individuals with a personal history of chronic rheumatic heart disease (OR = 0.55; 0.33-0.93), particularly persons with a long latency (10+ years) between the 2 conditions. We found no association between personal or familial occurrence of other autoimmune or related disorders and CLL. If our results are confirmed, mechanistic studies examining how pernicious anemia might promote increased occurrence of CLL and how chronic rheumatic heart disease protects against CLL, perhaps related to long-term antibiotics use, may provide insights to the as-yet-unknown etiology of CLL. (Blood. 2006;108:292-296) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Y. Kristinsson, L. R. Goldin, M. Bjorkholm, J. Koshiol, I. Turesson, and O. Landgren Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies Haematologica, November 1, 2009; 94(11): 1581 - 1589. [Abstract] [Full Text] [PDF] K. Hemminki, X. Li, J. Sundquist, and K. Sundquist Cancer risks in Crohn disease patients Ann. Onc., March 1, 2009; 20(3): 574 - 580. [Abstract] [Full Text] [PDF] O. Landgren, M. Albitar, W. Ma, F. Abbasi, R. B. Hayes, P. Ghia, G. E. Marti, and N. E. 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Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and Nutrition Haematologica, June 1, 2008; 93(6): 842 - 850. [Abstract] [Full Text] [PDF] K. Hemminki, X. Li, K. Sundquist, and J. Sundquist Cancer risk in hospitalized rheumatoid arthritis patients Rheumatology, May 1, 2008; 47(5): 698 - 701. [Abstract] [Full Text] [PDF] O. Landgren, J. S. Rapkin, N. E. Caporaso, L. Mellemkjaer, G. Gridley, L. R. Goldin, and E. A. Engels Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia Blood, March 1, 2007; 109(5): 2198 - 2201. [Abstract] [Full Text] [PDF] L. R. Goldin and S. L. Slager Familial CLL: Genes and Environment Hematology, January 1, 2007; 2007(1): 339 - 345. [Abstract] [Full Text] [PDF] O. Landgren, E. A. Engels, R. M. Pfeiffer, G. Gridley, L. Mellemkjaer, J. H. Olsen, K. F. Kerstann, W. Wheeler, K. Hemminki, M. S. Linet, et al. Autoimmunity and susceptibility to Hodgkin lymphoma: a population-based case-control study in Scandinavia. J Natl Cancer Inst, September 20, 2006; 98(18): 1321 - 1330. [Abstract] [Full Text] [PDF]

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