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Blood, 1 December 2006, Vol. 108, No. 12, pp. 3700-3706. Prepublished online as a Blood First Edition Paper on August 24, 2006; DOI 10.1182/blood-2006-03-011973. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-03-011973v1 108/12/3700    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fas, S. C. Articles by Li-Weber, M. Search for Related Content PubMed PubMed Citation Articles by Fas, S. C. Articles by Li-Weber, M. Related Collections Hematopoiesis and Stem Cells Immunobiology Neoplasia Apoptosis Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Wogonin sensitizes resistant malignant cells to TNF- and TRAIL-induced apoptosis Stefanie C. Fas, Sven Baumann, Jia Yun Zhu, Marco Giaisi, Monika K. Treiber, Ulrich Mahlknecht, Peter H. Krammer, and Min Li-Weber From the Tumorimmunology Program (D030), German Cancer Research Center (DKFZ), Heidelberg; and Department of Hematology/Oncology, University of Heidelberg Medical Center V, Germany. TNF has previously been used in anticancer therapy. However, the therapeutic application of TNF was largely limited due to its general toxicity and the fact that it activates the NF-B–family transcription factors, which are proinflammatory and antiapoptotic. To overcome this problem in vitro, specific NF-B inhibitors or transcription or protein synthesis inhibitors such as actinomycin D and cycloheximide are usually used in combination to increase TNF killing of tumor cells. However, these agents also cause harmful side effects in vivo. We show here that wogonin, derived from the popular Chinese herb Huang-Qin, attenuates NF-B activity by shifting TNF-induced free radical ·O2– to a more reduced nonradical product, H2O2, and thereby sensitizes TNF-resistant leukemia cells to TNF-induced apoptosis. Importantly, wogonin does not affect the viability of normal peripheral blood T cells. Wogonin also sensitizes TRAIL-induced apoptosis. Our data suggest a potential use of wogonin as a TNF or TRAIL adjuvant for cancer treatment. Our data also demonstrate how a herbal compound enhances killing of tumor cells with reduced side effects compared with other treatments. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: A TRAIL to Chinese herbal medicine Peter T. Daniel Blood 2006 108: 3634. [Full Text] [PDF] This article has been cited by other articles: G Kallifatidis, V Rausch, B Baumann, A Apel, B M Beckermann, A Groth, J Mattern, Z Li, A Kolb, G Moldenhauer, et al. Sulforaphane targets pancreatic tumour-initiating cells by NF-{kappa}B-induced antiapoptotic signalling Gut, July 1, 2009; 58(7): 949 - 963. [Abstract] [Full Text] [PDF] W. Lu, Q. Li, J. Li, F. Liu, and X. Yang Polysaccharide from Patrinia heterophylla Bunge Inhibits HeLa Cell Proliferation Through Induction of Apoptosis and Cell Cycle Arrest Lab Med, March 1, 2009; 40(3): 161 - 166. [Abstract] [Full Text] [PDF] S. Baumann, S. C. Fas, M. Giaisi, W. W. Muller, A. Merling, K. Gulow, L. Edler, P. H. Krammer, and M. Li-Weber Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLC{gamma}1- and Ca2+-dependent apoptosis Blood, February 15, 2008; 111(4): 2354 - 2363. [Abstract] [Full Text] [PDF] H. Hasegawa, Y. Yamada, K. Komiyama, M. Hayashi, M. Ishibashi, T. Sunazuka, T. Izuhara, K. Sugahara, K. Tsuruda, M. Masuda, et al. A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-{Delta}12, 14 prostaglandin J2 production Blood, September 1, 2007; 110(5): 1664 - 1674. [Abstract] [Full Text] [PDF]

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