SEARCH:   Advanced

Blood, 15 December 2006, Vol. 108, No. 13, pp. 3979-3982. Prepublished online as a Blood First Edition Paper on August 17, 2006; DOI 10.1182/blood-2006-03-007732. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-03-007732v1 108/13/3979    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mesnard, J.-M. Articles by Devaux, C. Search for Related Content PubMed PubMed Citation Articles by Mesnard, J.-M. Articles by Devaux, C. Related Collections Perspectives Neoplasia Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PERSPECTIVES HBZ, a new important player in the mystery of adult T-cell leukemia Jean-Michel Mesnard, Benoît Barbeau, and Christian Devaux From the Laboratoire Infections Rétrovirales et Signalisation Cellulaire, Centre National de la Recherche Scientifique (CNRS) Unité mixte de recherche (UMR) 5121-UM1, Montpellier, France; and the Département des Sciences biologiques, Université du Québec à Montréal, Canada. Abstract Adult T-cell leukemia (ATL) was first described in 1977. A link between ATL and human T-cell leukemia virus type 1 (HTLV-1) was clearly established in the early 1980s. Over the years, many aspects of HTLV-1–induced cellular dysfunctions have been clarified. However, the detailed mechanism behind ATL occurrence remains unsolved. Presently, we are still unable to explain the absence of viral Tax protein (thought to play a central role in T-cell transformation) in more than 50% of ATL cells. A novel HTLV-1 HBZ protein, encoded on the negative strand, was characterized by our group and is currently the subject of intensive research efforts to determine its function in viral replication and/or pathophysiology. Recently, 4 studies reported on the existence of different HBZ isoforms and have investigated on their function in both ATL cells or animal models. One report suggests that the HBZ gene might have a bimodal function (at the mRNA and protein levels), which could represent an uncharacterized strategy to regulate viral replication and proliferation of infected T cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Fukumoto, V. Andresen, I. Bialuk, V. Cecchinato, J.-C. Walser, V. W. Valeri, J. M. Nauroth, A. Gessain, C. Nicot, and G. Franchini In vivo genetic mutations define predominant functions of the human T-cell leukemia/lymphoma virus p12I protein Blood, April 16, 2009; 113(16): 3726 - 3734. [Abstract] [Full Text] [PDF] M. Li, M. Kesic, H. Yin, L. Yu, and P. L. Green Kinetic Analysis of Human T-Cell Leukemia Virus Type 1 Gene Expression in Cell Culture and Infected Animals J. Virol., April 15, 2009; 83(8): 3788 - 3797. [Abstract] [Full Text] [PDF] J. Arnold, B. Zimmerman, M. Li, M. D. Lairmore, and P. L. Green Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation Blood, November 1, 2008; 112(9): 3788 - 3797. [Abstract] [Full Text] [PDF] M. Liu, L. Yang, L. Zhang, B. Liu, R. Merling, Z. Xia, and C.-Z. Giam Human T-Cell Leukemia Virus Type 1 Infection Leads to Arrest in the G1 Phase of the Cell Cycle J. Virol., September 1, 2008; 82(17): 8442 - 8455. [Abstract] [Full Text] [PDF] I. Clerc, N. Polakowski, C. Andre-Arpin, P. Cook, B. Barbeau, J.-M. Mesnard, and I. Lemasson An Interaction between the Human T Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) and the KIX Domain of p300/CBP Contributes to the Down-regulation of Tax-dependent Viral Transcription by HBZ J. Biol. Chem., August 29, 2008; 283(35): 23903 - 23913. [Abstract] [Full Text] [PDF] K. Pichler, T. Kattan, J. Gentzsch, A. K. Kress, G. P. Taylor, C. R. M. Bangham, and R. Grassmann Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein Blood, May 1, 2008; 111(9): 4741 - 4751. [Abstract] [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020