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 Blood, 15 December 2006, Vol. 108, No. 13, pp. 3992-3996.
Prepublished online as a Blood First Edition Paper on August 17, 2006; DOI 10.1182/blood-2006-05-026112.

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REVIEW IN TRANSLATIONAL HEMATOLOGY

Multiple myeloma bone disease: pathophysiology of osteoblast inhibition

Nicola Giuliani, Vittorio Rizzoli, and G. David Roodman

From the Cattedra e Unità Operativa (UO) di Ematologia–Centro Trapianti Midollo Osseo (CTMO), Università Degli Studi di Parma, Italy; and University of Pittsburgh School of Medicine and Veterans Administration (VA) Medical Center, PA.

Abstract

Multiple myeloma (MM) is a plasma cell malignancy characterized by a high capacity to induce osteolytic bone lesions. Bone destruction in MM results from increased osteoclast formation and activity that occur in close proximity to myeloma cells. However, histomorphometric studies have demonstrated that MM patients with osteolytic bone lesions have lower numbers of osteoblasts and decreased bone formation. This impaired bone formation plays a critical role in the bone-destructive process. Recently, the biologic mechanisms involved in the osteoblast inhibition induced by MM cells have begun to be elucidated. In this article, the pathophysiology underlying osteoblast inhibition in MM is reviewed.


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