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Blood, 15 December 2006, Vol. 108, No. 13, pp. 4288-4290. Prepublished online as a Blood First Edition Paper on August 31, 2006; DOI 10.1182/blood-2006-05-024042. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-024042v1 108/13/4288    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schmitz, N. Articles by Champlin, R. E. Search for Related Content PubMed PubMed Citation Articles by Schmitz, N. Articles by Champlin, R. E. Related Collections Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Long-term outcome of patients given transplants of mobilized blood or bone marrow: a report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation Norbert Schmitz, Mary Eapen, Mary M. Horowitz, Mei-Jie Zhang, John P. Klein, J. Douglas Rizzo, Fausto R. Loberiza, Alois Gratwohl, and Richard E. Champlin From the Department of Hematology, Asklepios Klinik St Georg, Hamburg, Germany; International Bone Marrow Transplant Registry, Health Policy Institute, Medical College of Wisconsin, Milwaukee, WI; University of Nebraska Medical Center, Omaha, NE; Kantonsspital Basel, Basel, Switzerland; M. D. Anderson Cancer Center, Houston, TX. We previously compared outcomes after allogeneic peripheral-blood stem cell (PBSC) and bone marrow (BM) transplantation in 706 patients with leukemia. We obtained long-term follow up on 413 of 491 patients who were alive at the time of the initial report: 141 PBSC and 272 BM recipients. Chronic graft-versus-host disease (GVHD) was more frequent after PBSC compared to BM transplantation (RR 1.65, P < .001) yet relapse rates were similar in both groups. Leukemia-free survival rates were higher after PBSC than BM transplantation for patients with advanced chronic myeloid leukemia (33% versus 25%) but lower for those in first chronic phase (41% versus 61%) due to higher rates of late transplant-related mortality. Leukemia-free survival was similar after PBSC and BM transplantation for acute leukemia. These data represent the early experience with PBSC grafts. Long-term outcomes in recipients of more recent transplants are required to better evaluate the role of PBSC grafts relative to BM transplantation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. H. C. Baumeister, K. Holig, M. Bornhauser, M. Meurer, E. P. Rieber, and K. Schakel G-CSF mobilizes slanDCs (6-sulfo LacNAc+ dendritic cells) with a high proinflammatory capacity Blood, October 15, 2007; 110(8): 3078 - 3081. [Abstract] [Full Text] [PDF] H. Schrezenmeier, J. R. Passweg, J. C. W. Marsh, A. Bacigalupo, C. N. Bredeson, E. Bullorsky, B. M. Camitta, R. E. Champlin, R. P. Gale, M. Fuhrer, et al. Worse outcome and more chronic GVHD with peripheral blood progenitor cells than bone marrow in HLA-matched sibling donor transplants for young patients with severe acquired aplastic anemia Blood, August 15, 2007; 110(4): 1397 - 1400. [Abstract] [Full Text] [PDF]

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