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Blood, 15 July 2006, Vol. 108, No. 2, pp. 426-431.
Prepublished online as a Blood First Edition Paper on March 14, 2006; DOI 10.1182/blood-2006-01-0177.
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REVIEW ARTICLES
Regulatory T-cell compartmentalization and trafficking
Shuang Wei,
Ilona Kryczek, and
Weiping Zou
From the Department of Surgery, University of Michigan, Ann Arbor.
CD4+CD25+FOXP3+ regulatory T cells (CD4+ Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-presenting cells (APCs) and T cells, is crucial for ensuring suppression by Treg cells in the appropriate microenvironment. Emerging evidence suggests that Treg compartmentalization and trafficking may be tissue or/and organ specific and that distinct chemokine receptor and integrin expression may contribute to selective retention and trafficking of Treg cells at sites where regulation is required. In this review, the cellular and molecular signals that control specialized migration and retention of Treg cells are discussed.
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