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Blood, 15 July 2006, Vol. 108, No. 2, pp. 460-464. Prepublished online as a Blood First Edition Paper on March 21, 2006; DOI 10.1182/blood-2005-11-4407. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-11-4407v1 108/2/460    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Arnold, D. M. Articles by Walker, I. R. Search for Related Content PubMed PubMed Citation Articles by Arnold, D. M. Articles by Walker, I. R. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up Donald M. Arnold, Jim A. Julian, Irwin R. Walker, for the Association of Hemophilia Clinic Directors of Canada From McMaster University, Hamilton, ON; Canadian Blood Services; The Association of Hemophilia Clinic Directors of Canada; and the Canadian Association of Nurses in Hemophilia Care, Toronto, ON, Canada. Many individuals with hemophilia were infected with human immunodeficiency virus (HIV) in the early 1980s through contaminated blood products. Most also were co-infected with hepatitis C virus (HCV). Deaths among the entire cohort of HIV-positive hemophiliacs in Canada up to 2003 are described. Using registry data, we analyzed Kaplan-Meier survival curves, determined the effect of age at HIV seroconversion on mortality, and described cause-specific proportional mortality patterns over time. Of 2427 Canadians with hemophilia, 660 (27.2%) were HIV-positive, of whom 406 (61.5%) died. In contrast, 114 (6.5%) deaths occurred in HIV-negative controls. Median age at HIV seroconversion was 20 (range, < 1-67 years), and median survival was 15.0 years (95% confidence interval, 13.6-16.4 years). Younger age at HIV seroconversion was associated with improved survival; however, this finding was not explained by differences in causes of death across age groups. Following the introduction of highly active antiretroviral therapy, the proportion of deaths due to acquired immune deficiency syndrome has decreased, while the proportion of deaths due to liver disease has increased. There were 1134 HCV-positive individuals, of whom only 444 (39.2%) were also HIV-positive. Liver disease is a growing health concern among many hemophiliacs, not only those who are HIV-positive. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Rotman and T. J. Liang Coinfection with Hepatitis C Virus and Human Immunodeficiency Virus: Virological, Immunological, and Clinical Outcomes J. Virol., August 1, 2009; 83(15): 7366 - 7374. [Full Text] [PDF]

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