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Blood, 15 July 2006, Vol. 108, No. 2, pp. 745-748.
Prepublished online as a Blood First Edition Paper on March 28, 2006; DOI 10.1182/blood-2005-12-5156.
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TRANSFUSION MEDICINE
The neuropathologic phenotype of experimental ovine BSE is maintained after blood transfusion
Sílvia Sisó,
Lorenzo González,
Fiona Houston,
Nora Hunter,
Stuart Martin, and
Martin Jeffrey
From the Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian; the Institute for Animal Health, Compton, Berkshire; and the Institute for Animal Health Neuropathogenesis Unit, Edinburgh, United Kingdom.
Iatrogenic transmission by blood transfusion has been described in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bovine spongiform encephalopathy (BSE), and natural sheep scrapie, demonstrating that blood in these prion diseases is infectious. However, the possible effect of the transfusion, derived from differences in the inoculum (blood) and the route of infection (intravenous), on the pathologic phenotype of the disease in the recipients is not known. This study describes the neuropathologic phenotype of PrPd accumulation in sheep succumbing to neurologic disease after blood transfusion from donors experimentally infected with BSE; these were either clinically or subclinically affected at the time of donation. We demonstrate that blood can become infectious at early stages of ovine BSE infection and that the PrPd immunohistochemical phenotype is maintained after transfusion. This suggests that a change in the pathologic phenotype of vCJD would not be expected as a result of exposure to infected blood.
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