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Blood, 15 July 2006, Vol. 108, No. 2, pp. 745-748. Prepublished online as a Blood First Edition Paper on March 28, 2006; DOI 10.1182/blood-2005-12-5156. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-12-5156v1 108/2/745    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sisó, S. Articles by Jeffrey, M. Search for Related Content PubMed PubMed Citation Articles by Sisó, S. Articles by Jeffrey, M. Related Collections Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSFUSION MEDICINE The neuropathologic phenotype of experimental ovine BSE is maintained after blood transfusion Sílvia Sisó, Lorenzo González, Fiona Houston, Nora Hunter, Stuart Martin, and Martin Jeffrey From the Veterinary Laboratories Agency (VLA-Lasswade), Pentlands Science Park, Bush Loan, Midlothian; the Institute for Animal Health, Compton, Berkshire; and the Institute for Animal Health Neuropathogenesis Unit, Edinburgh, United Kingdom. Iatrogenic transmission by blood transfusion has been described in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bovine spongiform encephalopathy (BSE), and natural sheep scrapie, demonstrating that blood in these prion diseases is infectious. However, the possible effect of the transfusion, derived from differences in the inoculum (blood) and the route of infection (intravenous), on the pathologic phenotype of the disease in the recipients is not known. This study describes the neuropathologic phenotype of PrPd accumulation in sheep succumbing to neurologic disease after blood transfusion from donors experimentally infected with BSE; these were either clinically or subclinically affected at the time of donation. We demonstrate that blood can become infectious at early stages of ovine BSE infection and that the PrPd immunohistochemical phenotype is maintained after transfusion. This suggests that a change in the pathologic phenotype of vCJD would not be expected as a result of exposure to infected blood. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Ramirez and J. F. DiPersio Therapy Options in Imatinib Failures Oncologist, April 1, 2008; 13(4): 424 - 434. [Abstract] [Full Text] [PDF] O. Andrievskaia, J. Algire, A. Balachandran, and K. Nielsen Prion protein in sheep urine J Vet Diagn Invest, March 1, 2008; 20(2): 141 - 146. [Abstract] [Full Text] [PDF] S. L. Eaton, M. Rocchi, L. Gonzalez, S. Hamilton, J. Finlayson, J. Sales, M. Jeffrey, P. J. Steele, M. P. Dagleish, S. M. Rodger, et al. Immunological differences between susceptible and resistant sheep during the preclinical phase of scrapie infection J. Gen. Virol., April 1, 2007; 88(4): 1384 - 1391. [Abstract] [Full Text] [PDF]

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