|
|
Blood, 1 August 2006, Vol. 108, No. 3, pp. 965-973.
Prepublished online as a Blood First Edition Paper on April 6, 2006; DOI 10.1182/blood-2005-12-5046.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
Antje Blumenthal,
Stefan Ehlers,
Jörg Lauber,
Jan Buer,
Christoph Lange,
Torsten Goldmann,
Holger Heine,
Ernst Brandt, and
Norbert Reiling
From the Division of Molecular Infection Biology, Division of Clinical Infectious Diseases, Division of Clinical and Experimental Pathology, Division of Innate Immunity, and Division of Biological Chemistry, Research Center Borstel (RCB), Leibniz Center for Medicine and Biosciences, Borstel, Germany; Department of Mucosal Immunity, The German Research Center for Biotechnology (GBF), Braunschweig, Germany; and the Institute of Medical Microbiology, Hannover Medical School, Hannover, Germany.
Microarray - assisted gene - expression screens of human macrophages revealed WNT5A, a homolog of Wingless, a key regulator of Drosophila melanogaster embryonic segmentation and patterning, to be consistently up-regulated following stimulation with different mycobacterial species and conserved bacterial structures. The expression of WNT5A required Toll-like receptor signaling and NF- B activation, which identifies a novel induction pathway for a Wingless homolog. We show that human peripheral-blood mononuclear cells express the WNT5A receptor Frizzled-5 (FZD5). Both WNT5A and FZD5 also were detected in granulomatous lesions in the lungs of Mycobacterium tuberculosis–infected patients. Functional studies showed that WNT5A and FZD5 regulate the microbially induced interleukin-12 response of antigen-presenting cells and interferon- production by mycobacterial antigenstimulated T cells. Our findings implicate the evolutionarily conserved WNT/Frizzled signaling system in bridging innate and adaptive immunity to infections.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
Macrophage activation:'tis the way the WNT blows
- Jeff Schorey
Blood 2006 108: 784.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
M. A. Christman II, D. J. Goetz, E. Dickerson, K. D. McCall, C. J. Lewis, F. Benencia, M. J. Silver, L. D. Kohn, and R. Malgor
Wnt5a is expressed in murine and human atherosclerotic lesions
Am J Physiol Heart Circ Physiol,
June 1, 2008;
294(6):
H2864 - H2870.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. George
Wnt Pathway: A New Role in Regulation of Inflammation
Arterioscler. Thromb. Vasc. Biol.,
March 1, 2008;
28(3):
400 - 402.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Pereira, D. J. Schaer, E. B. Bachli, M. O. Kurrer, and G. Schoedon
Wnt5A/CaMKII Signaling Contributes to the Inflammatory Response of Macrophages and Is a Target for the Antiinflammatory Action of Activated Protein C and Interleukin-10
Arterioscler. Thromb. Vasc. Biol.,
March 1, 2008;
28(3):
504 - 510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Lehtonen, H. Ahlfors, V. Veckman, M. Miettinen, R. Lahesmaa, and I. Julkunen
Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells
J. Leukoc. Biol.,
September 1, 2007;
82(3):
710 - 720.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. McCall, N. Harii, C. J. Lewis, R. Malgor, W. Bae Kim, M. Saji, A. D. Kohn, R. T. Moon, and L. D. Kohn
High Basal Levels of Functional Toll-Like Receptor 3 (TLR3) and Noncanonical Wnt5a Are Expressed in Papillary Thyroid Cancer and Are Coordinately Decreased by Phenylmethimazole Together with Cell Proliferation and Migration
Endocrinology,
September 1, 2007;
148(9):
4226 - 4237.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. MacLeod, M. Hayes, and I. Pacheco
Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells
Am J Physiol Gastrointest Liver Physiol,
July 1, 2007;
293(1):
G403 - G411.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
