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Blood, 15 August 2006, Vol. 108, No. 4, pp. 1129-1134. Prepublished online as a Blood First Edition Paper on April 11, 2006; DOI 10.1182/blood-2005-12-4795. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-12-4795v1 108/4/1129    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dentali, F. Articles by Ageno, W. Search for Related Content PubMed PubMed Citation Articles by Dentali, F. Articles by Ageno, W. Related Collections Hemostasis, Thrombosis, and Vascular Biology Free Research Articles Review Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW ARTICLES Natural history of cerebral vein thrombosis: a systematic review Francesco Dentali, Monica Gianni, Mark A. Crowther, and Walter Ageno From the Department of Medicine, McMaster University, Hamilton; and the Division of Cardiology, Department of Medicine, McMaster University, Hamilton, ON, Canada; and the Department of Clinical Medicine, University of Insubria, Varese, Italy. Cerebral vein thrombosis (CVT) has been considered, until a few years ago, an uncommon disease with significant long-term morbidity and high mortality rate. New noninvasive diagnostic techniques have increased the frequency with which this disease is diagnosed; despite this, there continues to be little data on its natural history. The objectives of this study were to evaluate the mortality rate, the rate of disability at long-term follow-up, and the incidence of recurrence after a first episode of CVT; to determine clinical and radiologic predictors of death and dependence; and to identify possible risk factors for recurrence. (Data source: MEDLINE and EMBASE databases, reference lists of selected articles and authors' libraries.) Nineteen studies were identified. Mortality rate during peri-hospitalization period is 5.6% (range, 0%-15.2%) and 9.4% (range, 0%-39%) at the end of follow-up period. Eighty-eight percent of surviving patients recover completely or have only a mild functional or cognitive deficit. Two thirds of patients with CVT recanalized within the first few months after presentation, and 2.8% (range, 0%-11.7%) had objectively confirmed recurrence. We conclude that patients with CVT have a low risk of death and that most patients have a good long-term prognosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I. Martinelli, M. Franchini, and P. M. Mannucci How I treat rare venous thromboses Blood, December 15, 2008; 112(13): 4818 - 4823. [Abstract] [Full Text] [PDF] J. M. Ferro, P. Canhao, M.-G. Bousser, J. Stam, F. Barinagarrementeria, and for the ISCVT Investigators Early Seizures in Cerebral Vein and Dural Sinus Thrombosis: Risk Factors and Role of Antiepileptics Stroke, April 1, 2008; 39(4): 1152 - 1158. [Abstract] [Full Text] [PDF] T. Barbui and G. Finazzi Myeloproliferative Disease in Pregnancy and Other Management Issues Hematology, January 1, 2006; 2006(1): 246 - 252. [Abstract] [Full Text] [PDF]

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