|
|
Blood, 15 August 2006, Vol. 108, No. 4, pp. 1243-1250.
Prepublished online as a Blood First Edition Paper on April 18, 2006; DOI 10.1182/blood-2005-11-4447.
 Previous Article | Table of Contents | Next Article 
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration
Benoit Favier,
Antoine Alam,
Pauline Barron,
Jacques Bonnin,
Patricia Laboudie,
Pierre Fons,
Marie Mandron,
Jean-Pascal Herault,
Gera Neufeld,
Pierre Savi,
Jean-Marc Herbert, and
Françoise Bono
From the Sanofi-Synthelabo Research, Angiogenesis and Thrombosis Department, Toulouse, France; and the Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Neuropilin 2 (NRP2) is a receptor for the vascular endothelial growth factor (VEGF) and the semaphorin (SEMA) families, 2 unrelated ligand families involved in angiogenesis and neuronal guidance. NRP2 specifically binds VEGF-A and VEGF-C, although the biological relevance of these interactions in human endothelial cells is poorly understood. In this study, we show that both VEGF-A and VEGF-C induce the interaction of NRP2 with VEGFR-2. This interaction correlated with an enhancement of the VEGFR-2 phosphorylation threshold. Overexpression of NRP2 in primary human endothelial cells promoted cell survival induced by VEGF-A and VEGF-C. In contrast, SEMA3F, another ligand for NRP2, was able to inhibit human endothelial cell survival and migration induced by VEGF-A and VEGF-C. Moreover, a siRNA targeting specifically NRP2 was a potent inhibitor of human endothelial cell migration induced by VEGF-A and VEGF-C. Thus, our data indicate that NRP2 acts as a coreceptor that enhances human endothelial cell biological responses induced by VEGF-A and VEGF-C.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. Sulpice, J. Plouet, M. Berge, D. Allanic, G. Tobelem, and T. Merkulova-Rainon
Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity
Blood,
February 15, 2008;
111(4):
2036 - 2045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Gray, G. Van Buren, N. A. Dallas, L. Xia, X. Wang, A. D. Yang, R. J. Somcio, Y. G. Lin, S. Lim, F. Fan, et al.
Therapeutic Targeting of Neuropilin-2 on Colorectal Carcinoma Cells Implanted in the Murine Liver
J Natl Cancer Inst,
January 16, 2008;
100(2):
109 - 120.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Curreli, Z. Arany, R. Gerardy-Schahn, D. Mann, and N. M. Stamatos
Polysialylated Neuropilin-2 Is Expressed on the Surface of Human Dendritic Cells and Modulates Dendritic Cell-T Lymphocyte Interactions
J. Biol. Chem.,
October 19, 2007;
282(42):
30346 - 30356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Airoldi, E. Di Carlo, C. Cocco, G. Taverniti, T. D'Antuono, E. Ognio, M. Watanabe, D. Ribatti, and V. Pistoia
From the Cover: Endogenous IL-12 triggers an antiangiogenic program in melanoma cells
PNAS,
March 6, 2007;
104(10):
3996 - 4001.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cariboni, J. Hickok, S. Rakic, W. Andrews, R. Maggi, S. Tischkau, and J. G. Parnavelas
Neuropilins and Their Ligands Are Important in the Migration of Gonadotropin-Releasing Hormone Neurons
J. Neurosci.,
February 28, 2007;
27(9):
2387 - 2395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hochman, A. Castiel, J. Jacob-Hirsch, N. Amariglio, and S. Izraeli
Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling
J. Biol. Chem.,
November 10, 2006;
281(45):
33860 - 33870.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
