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Blood, 15 August 2006, Vol. 108, No. 4, pp. 1363-1369. Prepublished online as a Blood First Edition Paper on April 18, 2006; DOI 10.1182/blood-2005-12-008755. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2005-12-008755v1 108/4/1363    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chiu, B. C.-H. Articles by Weisenburger, D. D. Search for Related Content PubMed PubMed Citation Articles by Chiu, B. C.-H. Articles by Weisenburger, D. D. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma Brian C.-H. Chiu, Bhavana J. Dave, Aaron Blair, Susan M. Gapstur, Shelia Hoar Zahm, and Dennis D. Weisenburger From the Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL; the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; the Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha; the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD. Pesticides have been specifically associated with the t(14;18)(q32;q21) chromosomal translocation. To investigate whether the association between pesticides and risk of non-Hodgkin lymphoma (NHL) differs for molecular subtypes of NHL defined by t(14; 18) status, we obtained 175 tumor blocks from case subjects in a population-based case-control study conducted in Nebraska between 1983 and 1986. The t(14;18) was determined by interphase fluorescence in situ hybridization in 172 of 175 tumor blocks. We compared exposures to insecticides, herbicides, fungicides, and fumigants in 65 t(14;18)-positive and 107 t(14;18)-negative case subjects with those among 1432 control subjects. Multivariate polytomous logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Compared with farmers who never used pesticides, the risk of t(14;18)-positive NHL was significantly elevated among farmers who used animal insecticides (OR = 2.6; 95% CI, 1.0-6.9), crop insecticides (OR = 3.0; 95% CI, 1.1-8.2), herbicides (OR = 2.9; 95% CI, 1.1-7.9), and fumigants (OR = 5.0; 95% CI, 1.7-14.5). None of these pesticides were associated with t(14;18)-negative NHL. The risk of t(14;18)-positive NHL associated with insecticides and herbicides increased with longer duration of use. We conclude that insecticides, herbicides, and fumigants were associated with risk of t(14;18)-positive NHL but not t(14;18)-negative NHL. These results suggest that defining subsets of NHL according to t(14;18) status is a useful approach for etiologic research. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Agopian, J.-M. Navarro, A.-C. Gac, Y. Lecluse, M. Briand, P. Grenot, P. Gauduchon, P. Ruminy, P. Lebailly, B. Nadel, et al. Agricultural pesticide exposure and the molecular connection to lymphomagenesis J. Exp. Med., July 6, 2009; 206(7): 1473 - 1483. [Abstract] [Full Text] [PDF] L. M. Morton, S. S. Wang, W. Cozen, M. S. Linet, N. Chatterjee, S. Davis, R. K. Severson, J. S. Colt, M. A. Vasef, N. Rothman, et al. Etiologic heterogeneity among non-Hodgkin lymphoma subtypes Blood, December 15, 2008; 112(13): 5150 - 5160. [Abstract] [Full Text] [PDF] G. Dolken, L. Dolken, C. Hirt, C. Fusch, C. S. Rabkin, and F. Schuler Age-Dependent Prevalence and Frequency of Circulating t(14;18)-Positive Cells in the Peripheral Blood of Healthy Individuals J Natl Cancer Inst Monographs, July 1, 2008; 2008(39): 44 - 47. [Abstract] [Full Text] [PDF] B. C.-H. Chiu, Q. Lan, B. J. Dave, A. Blair, S. H. Zahm, and D. D. Weisenburger The Utility of t(14;18) in Understanding Risk Factors for Non-Hodgkin Lymphoma J Natl Cancer Inst Monographs, July 1, 2008; 2008(39): 69 - 73. [Abstract] [Full Text] [PDF] L. M. Morton, J. J. Turner, J. R. Cerhan, M. S. Linet, P. A. Treseler, C. A. Clarke, A. Jack, W. Cozen, M. Maynadie, J. J. Spinelli, et al. Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph) Blood, July 15, 2007; 110(2): 695 - 708. [Abstract] [Full Text] [PDF] L. S. Engel, F. Laden, A. Andersen, P. T. Strickland, A. Blair, L. L. Needham, D. B. Barr, M. S. Wolff, K. Helzlsouer, D. J. Hunter, et al. Polychlorinated Biphenyl Levels in Peripheral Blood and Non-Hodgkin's Lymphoma: A Report from Three Cohorts Cancer Res., June 1, 2007; 67(11): 5545 - 5552. [Abstract] [Full Text] [PDF] B. C.-H. Chiu, B. J. Dave, A. Blair, S. M. Gapstur, J. S. Chmiel, A. J. Fought, S. H. Zahm, and D. D. Weisenburger Cigarette Smoking, Familial Hematopoietic Cancer, Hair Dye Use, and Risk of t(14;18)-defined Subtypes of Non-Hodgkin's Lymphoma Am. J. Epidemiol., March 15, 2007; 165(6): 652 - 659. [Abstract] [Full Text] [PDF] S. Roulland, J.-M. Navarro, P. Grenot, M. Milili, J. Agopian, B. Montpellier, P. Gauduchon, P. Lebailly, C. Schiff, and B. Nadel Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis J. Exp. Med., October 30, 2006; 203(11): 2425 - 2431. [Abstract] [Full Text] [PDF]

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